iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gga-040155

Ensembl Protein ID

ENSGALP00000027070.3

UniProt Accession

F1P4Q4; F1P4Q4_CHICK

Genbank Protein ID

ENSGALP00000027070

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AADN04000283

Gene Name

NCK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000016799.5	ENSGALT00000027121.5	ENSGALP00000027070.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.50e-44	150.1	196	255

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           ++++vq+ly++++++++eL+++kG++++viek e+d +W+k+ k+ +g+ Gl+P+n+v+ +
   Q: 196  VLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKC-KNSRGQIGLVPKNYVVII 255
           5789**************************************.7**************876 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANKTGY VPSNYVERKN 60
SLKKGSLVKN LKDTLGLGKT KRKTSARDAS PTPSTDAEYP SNGSSADRIY DLNIPAYVKF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTCTCGGA GCACGCAGCC CGCATCCGCC TGTGGAAGGG AAGAGGAAAG CGGAGGGGGG 60
GAGCGAGCGA GCGAGCGGGT ACCGCCGCCG AGGAGACAAA GAAGCGGAGC CCGCCCGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0012506--C:vesicle membrane
GO:0007015--P:actin filament organization
GO:0016477--P:cell migration
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0030838--P:positive regulation of actin filament polymerization
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001404	Ailuropoda melanoleuca	92.37	0.00e+00	724.00
IUUC-Apl-003456	Anas platyrhynchos	99.74	0.00e+00	764.00
IUUC-Aca-005105	Anolis carolinensis	97.37	0.00e+00	749.00
IUUC-Ame-010966	Astyanax mexicanus	78.91	7.00e-178	615.00
IUUC-Bta-012424	Bos taurus	84.74	0.00e+00	634.00
IUUC-Cel-018144	Caenorhabditis elegans	42.16	6.00e-77	280.00
IUUC-Cja-019898	Callithrix jacchus	92.63	0.00e+00	727.00
IUUC-Cfa-020830	Canis familiaris	91.32	0.00e+00	718.00
IUUC-Cpo-021487	Cavia porcellus	84.47	0.00e+00	640.00
IUUC-Csa-023693	Chlorocebus sabaeus	93.16	0.00e+00	730.00
IUUC-Cho-024368	Choloepus hoffmanni	66.09	9.00e-133	466.00
IUUC-Cin-025348	Ciona intestinalis	38.79	2.00e-69	256.00
IUUC-Csv-026046	Ciona savignyi	39.55	2.00e-71	262.00
IUUC-Dre-028334	Danio rerio	81.98	0.00e+00	628.00
IUUC-Dno-028973	Dasypus novemcinctus	93.42	0.00e+00	726.00
IUUC-Dor-031003	Dipodomys ordii	90.53	0.00e+00	683.00
IUUC-Dme-031846	Drosophila melanogaster	40.29	2.00e-88	319.00
IUUC-Ete-032792	Echinops telfairi	85.16	0.00e+00	657.00
IUUC-Eca-033656	Equus caballus	92.63	0.00e+00	726.00
IUUC-Eeu-034743	Erinaceus europaeus	63.78	4.00e-140	490.00
IUUC-Fca-036347	Felis catus	92.63	0.00e+00	725.00
IUUC-Fal-037095	Ficedula albicollis	98.95	0.00e+00	761.00
IUUC-Gmo-039410	Gadus morhua	69.90	3.00e-161	560.00
IUUC-Gac-041787	Gasterosteus aculeatus	72.34	3.00e-166	577.00
IUUC-Ggo-044805	Gorilla gorilla	92.89	0.00e+00	728.00
IUUC-Hsa-046585	Homo sapiens	92.89	0.00e+00	728.00
IUUC-Itr-048887	Ictidomys tridecemlineatus	91.05	0.00e+00	698.00
IUUC-Lch-049795	Latimeria chalumnae	92.89	0.00e+00	719.00
IUUC-Loc-051985	Lepisosteus oculatus	90.79	0.00e+00	681.00
IUUC-Laf-054228	Loxodonta africana	95.26	0.00e+00	735.00
IUUC-Mcc-055402	Macaca mulatta	93.16	0.00e+00	730.00
IUUC-Meu-056139	Macropus eugenii	65.62	2.00e-144	504.00
IUUC-Mga-059374	Meleagris gallopavo	100.00	0.00e+00	764.00
IUUC-Mmr-061453	Microcebus murinus	92.37	0.00e+00	724.00
IUUC-Mdo-063080	Monodelphis domestica	96.58	0.00e+00	746.00
IUUC-Mmu-063529	Mus musculus	89.47	0.00e+00	695.00
IUUC-Mpu-066815	Mustela putorius furo	92.37	0.00e+00	724.00
IUUC-Mlu-067132	Myotis lucifugus	88.85	2.00e-158	550.00
IUUC-Nle-069371	Nomascus leucogenys	92.89	0.00e+00	728.00
IUUC-Opr-070948	Ochotona princeps	91.78	0.00e+00	683.00
IUUC-Ont-071410	Oreochromis niloticus	75.57	6.00e-165	573.00
IUUC-Oan-073304	Ornithorhynchus anatinus	95.42	3.00e-168	583.00
IUUC-Ocu-074783	Oryctolagus cuniculus	91.84	0.00e+00	703.00
IUUC-Ola-086808	Oryzias latipes	72.89	7.00e-161	559.00
IUUC-Oga-088391	Otolemur garnettii	92.89	0.00e+00	712.00
IUUC-Oar-090025	Ovis aries	79.47	7.00e-166	575.00
IUUC-Ptr-090975	Pan troglodytes	92.89	0.00e+00	728.00
IUUC-Pan-092287	Papio anubis	93.16	0.00e+00	730.00
IUUC-Psi-093413	Pelodiscus sinensis	98.42	0.00e+00	755.00
IUUC-Pfo-097129	Poecilia formosa	76.46	3.00e-171	593.00
IUUC-Pab-098756	Pongo abelii	92.89	0.00e+00	728.00
IUUC-Pca-100235	Procavia capensis	82.11	0.00e+00	642.00
IUUC-Pva-102294	Pteropus vampyrus	88.95	0.00e+00	692.00
IUUC-Rno-105090	Rattus norvegicus	89.47	0.00e+00	695.00
IUUC-Sha-107521	Sarcophilus harrisii	96.58	0.00e+00	749.00
IUUC-Sar-113697	Sorex araneus	84.38	0.00e+00	645.00
IUUC-Ssc-115958	Sus scrofa	83.54	4.00e-162	563.00
IUUC-Tgu-116559	Taeniopygia guttata	96.84	0.00e+00	735.00
IUUC-Tru-117677	Takifugu rubripes	75.70	5.00e-167	580.00
IUUC-Tsy-119184	Tarsius syrichta	63.46	1.00e-128	452.00
IUUC-Tni-120434	Tetraodon nigroviridis	75.71	3.00e-164	570.00
IUUC-Tbe-127931	Tupaia belangeri	90.82	3.00e-176	610.00
IUUC-Ttr-128993	Tursiops truncatus	83.68	0.00e+00	640.00
IUUC-Vpa-130344	Vicugna pacos	69.03	1.00e-156	545.00
IUUC-Xtr-132543	Xenopus tropicalis	87.40	0.00e+00	687.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence