iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-034090

Ensembl Protein ID

ENSECAP00000016020.1

UniProt Accession

F7AT17; F7AT17_HORSE

Protein Name

Tyrosine-protein kinase

Gene Name

HCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000017707.1	ENSECAT00000019564.1	ENSECAP00000016020.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.80e-16	59.4	78	135

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +  v++lydyea + ++L ++kGd + v+   e++++W+++ + ++gk+G +P+n+v++++
   Q: 78   DTIVIALYDYEAIHHEDLRFQKGDEMVVL---EESGEWWRARSLATGKEGYIPSNYVARVD 135
           6789*************************...99*************************97 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

LGGRSSCEDP GCPQEEERAP RMGCVKSRFL RDRGKVSKSE PGANPHNPVY VPDPTSAGKR 60
WPDSSNNNPP GHTEGAEDTI VIALYDYEAI HHEDLRFQKG DEMVVLEESG EWWRARSLAT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGGGGGGGC GCTCGAGCTG CGAGGATCCG GGCTGCCCGC AGGAGGAGGA GCGGGCACCC 60
AGGTGAGTGT CGCGGGCGGA AAAGGGGGGA CACCGGCCGG TGAGCTCGGC CTGAGGGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000140	Aegilops tauschii	31.01	4.00e-22	100.00
IUUC-Aml-001284	Ailuropoda melanoleuca	89.54	0.00e+00	973.00
IUUC-Apl-003285	Anas platyrhynchos	77.43	0.00e+00	790.00
IUUC-Aca-004724	Anolis carolinensis	76.42	0.00e+00	768.00
IUUC-Ame-011954	Astyanax mexicanus	74.70	0.00e+00	754.00
IUUC-Bta-013060	Bos taurus	92.18	0.00e+00	1013.00
IUUC-Bdi-014122	Brachypodium distachyon	31.78	2.00e-22	100.00
IUUC-Cja-019817	Callithrix jacchus	88.14	0.00e+00	902.00
IUUC-Cfa-020511	Canis familiaris	92.18	0.00e+00	1003.00
IUUC-Cpo-022538	Cavia porcellus	87.72	0.00e+00	917.00
IUUC-Csa-024143	Chlorocebus sabaeus	88.71	0.00e+00	920.00
IUUC-Dre-028157	Danio rerio	75.45	0.00e+00	770.00
IUUC-Dno-029761	Dasypus novemcinctus	88.29	0.00e+00	917.00
IUUC-Fca-035937	Felis catus	88.17	0.00e+00	936.00
IUUC-Fal-036624	Ficedula albicollis	76.18	0.00e+00	782.00
IUUC-Gmo-039009	Gadus morhua	71.29	0.00e+00	734.00
IUUC-Gga-040296	Gallus gallus	73.96	0.00e+00	764.00
IUUC-Gac-042362	Gasterosteus aculeatus	80.13	0.00e+00	755.00
IUUC-Ggo-044570	Gorilla gorilla	88.21	0.00e+00	948.00
IUUC-Hsa-046378	Homo sapiens	88.40	0.00e+00	958.00
IUUC-Itr-048695	Ictidomys tridecemlineatus	85.14	0.00e+00	915.00
IUUC-Loc-052904	Lepisosteus oculatus	77.36	0.00e+00	803.00
IUUC-Laf-053654	Loxodonta africana	87.90	0.00e+00	919.00
IUUC-Mcc-055317	Macaca mulatta	88.69	0.00e+00	924.00
IUUC-Mga-060194	Meleagris gallopavo	79.51	0.00e+00	745.00
IUUC-Mmr-061510	Microcebus murinus	86.71	0.00e+00	904.00
IUUC-Mdo-062035	Monodelphis domestica	82.18	0.00e+00	860.00
IUUC-Mmu-064037	Mus musculus	87.40	0.00e+00	963.00
IUUC-Mpu-066874	Mustela putorius furo	90.08	0.00e+00	946.00
IUUC-Mlu-068202	Myotis lucifugus	87.30	0.00e+00	891.00
IUUC-Nle-069222	Nomascus leucogenys	88.10	0.00e+00	912.00
IUUC-Opr-070705	Ochotona princeps	85.01	0.00e+00	930.00
IUUC-Ont-072347	Oreochromis niloticus	80.58	0.00e+00	741.00
IUUC-Ocu-074490	Oryctolagus cuniculus	85.49	0.00e+00	897.00
IUUC-Oba-075219	Oryza barthii	31.72	1.00e-21	98.60
IUUC-Olo-080886	Oryza longistaminata	31.72	8.00e-22	98.60
IUUC-Oni-082350	Oryza nivara	31.72	1.00e-21	98.20
IUUC-Opu-083900	Oryza punctata	31.72	4.00e-22	100.00
IUUC-Oru-085212	Oryza rufipogon	31.72	1.00e-21	98.20
IUUC-Ola-086521	Oryzias latipes	79.69	0.00e+00	752.00
IUUC-Oga-088153	Otolemur garnettii	87.72	0.00e+00	917.00
IUUC-Oar-090184	Ovis aries	89.60	0.00e+00	967.00
IUUC-Ptr-090505	Pan troglodytes	84.60	0.00e+00	896.00
IUUC-Pan-092260	Papio anubis	88.89	0.00e+00	925.00
IUUC-Pma-094311	Petromyzon marinus	73.42	0.00e+00	702.00
IUUC-Pfo-096566	Poecilia formosa	74.46	0.00e+00	772.00
IUUC-Pva-103021	Pteropus vampyrus	91.87	0.00e+00	961.00
IUUC-Rno-105309	Rattus norvegicus	87.48	0.00e+00	917.00
IUUC-Sha-107099	Sarcophilus harrisii	80.71	0.00e+00	848.00
IUUC-Sit-110451	Setaria italica	33.33	2.00e-22	101.00
IUUC-Sly-111528	Solanum lycopersicum	32.27	6.00e-23	102.00
IUUC-Stu-112831	Solanum tuberosum	31.82	4.00e-22	100.00
IUUC-Sbi-114009	Sorghum bicolor	33.80	6.00e-22	99.40
IUUC-Tgu-116912	Taeniopygia guttata	76.13	0.00e+00	774.00
IUUC-Tru-118449	Takifugu rubripes	80.00	0.00e+00	738.00
IUUC-Tae-123706	Triticum aestivum	32.31	6.00e-23	102.00
IUUC-Tur-126022	Triticum urartu	32.31	6.00e-23	102.00
IUUC-Tbe-128144	Tupaia belangeri	83.78	0.00e+00	765.00
IUUC-Xma-133902	Xiphophorus maculatus	74.75	0.00e+00	778.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence