iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132115

Ensembl Protein ID

ENSXETP00000019986.3

UniProt Accession

F6Z6G3; F6Z6G3_XENTR

Genbank Protein ID

ENSXETP00000019986

Protein Name

Optineurin

Genbank Nucleotide ID

AAMC01043534

Gene Name

optn

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000009111.3	ENSXETT00000019986.3	ENSXETP00000019986.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBAN	7.20e-18	64.5	409	465

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndsl 57
           ++e++et+ +L++Q+++Y++DF+aER++RE +++eke+L+ +++ + ++ +kl++ +
   Q: 409  HKEDIETIGLLRAQIDVYCADFHAERSARENIHQEKEQLEARLAYMIQESEKLKAEM 465
           89**************************************************99875 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MENGLLKHPH VINMENGHQD ASCDVFSMKN DAEMLEQIKQ LLMENNNLKE TMKQMNQEMK 60
ERLEELLKRH NQHLLDLNSE NELLRKELNS LREKNATSNQ GIPVCSNPEE TSESKQLKTQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGCTGCGT ATTTATGTGT CGGTAAGTGA ATGTCTGCTG CTGGGTTTCA GGCGTTGAGT 60
GCAGCGCTGT AGTCATTATC TCAGTCTCTT ACTAGCAAAA GAATTCACCA TGTGGTTTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR032939--Optineurin
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0070530--F:K63-linked polyubiquitin binding
GO:0006914--P:autophagy
GO:0090161--P:Golgi ribbon formation
GO:0000042--P:protein targeting to Golgi
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002037	Ailuropoda melanoleuca	42.25	5.00e-83	301.00
IUUC-Apl-003812	Anas platyrhynchos	42.46	4.00e-99	355.00
IUUC-Aca-004625	Anolis carolinensis	45.37	1.00e-101	363.00
IUUC-Ame-011116	Astyanax mexicanus	40.71	5.00e-43	169.00
IUUC-Bta-013240	Bos taurus	44.40	1.00e-100	360.00
IUUC-Cja-019911	Callithrix jacchus	44.73	2.00e-93	336.00
IUUC-Cfa-020330	Canis familiaris	45.29	2.00e-88	320.00
IUUC-Cpo-021753	Cavia porcellus	44.34	4.00e-90	325.00
IUUC-Csa-023662	Chlorocebus sabaeus	45.75	7.00e-93	334.00
IUUC-Cho-024574	Choloepus hoffmanni	40.93	2.00e-25	109.00
IUUC-Dre-027720	Danio rerio	36.36	4.00e-71	261.00
IUUC-Dno-029079	Dasypus novemcinctus	42.62	5.00e-84	305.00
IUUC-Dor-030890	Dipodomys ordii	46.04	4.00e-97	348.00
IUUC-Dme-032072	Drosophila melanogaster	30.61	7.00e-06	45.10
IUUC-Ete-032568	Echinops telfairi	47.39	5.00e-91	328.00
IUUC-Eca-033528	Equus caballus	43.38	1.00e-89	323.00
IUUC-Eeu-035219	Erinaceus europaeus	43.04	1.00e-92	333.00
IUUC-Fca-035852	Felis catus	43.69	3.00e-88	318.00
IUUC-Fal-036862	Ficedula albicollis	44.01	3.00e-97	348.00
IUUC-Gmo-038735	Gadus morhua	32.55	1.00e-50	194.00
IUUC-Gga-040939	Gallus gallus	43.53	1.00e-100	360.00
IUUC-Gac-041580	Gasterosteus aculeatus	35.58	7.00e-62	231.00
IUUC-Ggo-045034	Gorilla gorilla	40.77	7.00e-79	288.00
IUUC-Hsa-046624	Homo sapiens	46.01	7.00e-96	344.00
IUUC-Itr-048288	Ictidomys tridecemlineatus	42.88	2.00e-91	329.00
IUUC-Lch-049720	Latimeria chalumnae	40.90	1.00e-50	193.00
IUUC-Loc-052185	Lepisosteus oculatus	36.46	2.00e-73	270.00
IUUC-Laf-054079	Loxodonta africana	43.69	4.00e-88	318.00
IUUC-Mcc-055674	Macaca mulatta	45.52	7.00e-92	331.00
IUUC-Meu-056769	Macropus eugenii	51.57	5.00e-41	162.00
IUUC-Mga-060203	Meleagris gallopavo	42.73	2.00e-88	319.00
IUUC-Mmr-061492	Microcebus murinus	44.68	8.00e-91	327.00
IUUC-Mdo-063051	Monodelphis domestica	44.76	4.00e-101	362.00
IUUC-Mmu-063409	Mus musculus	44.27	5.00e-103	368.00
IUUC-Mpu-065907	Mustela putorius furo	41.35	2.00e-90	326.00
IUUC-Mlu-066957	Myotis lucifugus	42.86	2.00e-88	320.00
IUUC-Nle-069973	Nomascus leucogenys	45.93	8.00e-96	344.00
IUUC-Opr-071049	Ochotona princeps	41.09	7.00e-74	271.00
IUUC-Ont-071915	Oreochromis niloticus	37.69	7.00e-71	261.00
IUUC-Oan-072965	Ornithorhynchus anatinus	44.34	2.00e-100	359.00
IUUC-Ocu-074029	Oryctolagus cuniculus	41.56	8.00e-75	274.00
IUUC-Ola-087019	Oryzias latipes	34.14	2.00e-58	219.00
IUUC-Oga-088613	Otolemur garnettii	45.13	6.00e-93	334.00
IUUC-Oar-090386	Ovis aries	43.12	8.00e-100	357.00
IUUC-Ptr-091619	Pan troglodytes	44.89	6.00e-95	341.00
IUUC-Pan-092178	Papio anubis	45.41	5.00e-92	331.00
IUUC-Psi-093214	Pelodiscus sinensis	46.49	3.00e-100	358.00
IUUC-Pfo-096901	Poecilia formosa	36.85	2.00e-65	243.00
IUUC-Pab-097560	Pongo abelii	41.20	1.00e-76	280.00
IUUC-Pca-100853	Procavia capensis	51.09	1.00e-35	144.00
IUUC-Pva-102255	Pteropus vampyrus	42.99	7.00e-84	304.00
IUUC-Rno-105812	Rattus norvegicus	42.93	6.00e-100	358.00
IUUC-Sha-107225	Sarcophilus harrisii	46.52	2.00e-78	285.00
IUUC-Sar-113736	Sorex araneus	46.70	1.00e-59	224.00
IUUC-Ssc-115422	Sus scrofa	42.88	4.00e-97	348.00
IUUC-Tgu-116924	Taeniopygia guttata	41.93	3.00e-88	318.00
IUUC-Tru-117695	Takifugu rubripes	34.29	9.00e-62	231.00
IUUC-Tsy-119090	Tarsius syrichta	40.79	1.00e-43	170.00
IUUC-Tni-120645	Tetraodon nigroviridis	36.26	1.00e-70	260.00
IUUC-Tbe-127970	Tupaia belangeri	49.82	2.00e-59	223.00
IUUC-Ttr-129244	Tursiops truncatus	43.54	4.00e-92	332.00
IUUC-Vpa-130313	Vicugna pacos	44.53	1.00e-86	313.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence