iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000164117.13	ENST00000393674.6	ENSP00000377280.2
ENSG00000164117.13	ENST00000503293.5	ENSP00000422905.1
ENSG00000164117.13	ENST00000515664.5	ENSP00000427313.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	Mentha
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	18094045

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	37.50	3.00e-04	41.60	IUUC-Ath-007482

Organism

Homo sapiens

Functional Description
(View)

May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential).

Protein Sequence
(Fasta)

MGQGLWRVVR NQQLQQEGYS EQGYLTREQS RRMAASNISN TNHRKQVQGG IDIYHLLKAR 60
KSKEQEGFIN LEMLPPELSF TILSYLNATD LCLASCVWQD LANDELLWQG LCKSTWGHCS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTTAAAAG AATGAAAAGG CGGATCTGGT CATTCGTCTC CGCCCGGGGT CTCTGTAAGG 60
ACGGCGGAGA GAGGCGACCT CCGCCCAATA CCAGGCGCAG CCTTGCCGTC TCCTCGGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0621--Polymorphism
KW-1185--Reference proteome

Interpro

IPR001810--F-box_dom
IPR023394--Sec7_alpha_orthog
IPR000904--Sec7_dom

PROSITE

PS50181--FBOX
PS50190--SEC7

Pfam

PF12937--F-box-like
PF01369--Sec7

SMART

SM00222--Sec7

Gene Ontology

GO:0000151--C:ubiquitin ligase complex
GO:0005086--F:ARF guanyl-nucleotide exchange factor activity
GO:0032012--P:regulation of ARF protein signal transduction
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:26269

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002597	Amborella trichopoda	39.13	7.00e-04	37.40
IUUC-Aly-006435	Arabidopsis lyrata	30.65	2.00e-05	42.00
IUUC-Ath-007482	Arabidopsis thaliana	37.50	2.00e-05	41.60
IUUC-Bdi-014906	Brachypodium distachyon	30.43	9.00e-03	33.90
IUUC-Bol-016273	Brassica oleracea	31.75	2.00e-05	41.60
IUUC-Bra-016627	Brassica rapa	31.75	2.00e-05	41.60
IUUC-Ete-032914	Echinops telfairi	91.82	2.00e-56	211.00
IUUC-Gma-043301	Glycine max	31.25	1.00e-04	39.30
IUUC-Opr-070849	Ochotona princeps	94.74	3.00e-84	304.00
IUUC-Oan-072882	Ornithorhynchus anatinus	87.58	5.00e-78	283.00
IUUC-Obr-076578	Oryza brachyantha	35.48	6.00e-05	41.60
IUUC-Ogl-077389	Oryza glaberrima	36.92	1.20e-01	30.00
IUUC-Oin-079212	Oryza indica	36.92	1.20e-01	30.00
IUUC-Pop-098990	Populus trichocarpa	34.43	2.00e-04	38.90
IUUC-Ppe-102068	Prunus persica	34.43	5.00e-05	40.80
IUUC-Smo-108701	Selaginella moellendorffii	37.21	3.00e-04	37.70
IUUC-Sit-110635	Setaria italica	35.82	1.00e-03	36.20
IUUC-Tca-121336	Theobroma cacao	32.32	3.00e-05	41.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence