iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062227

Ensembl Protein ID

ENSMODP00000015185.3

UniProt Accession

F7FU48; F7FU48_MONDO

Protein Name

Tyrosine-protein kinase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000012126.3	ENSMODT00000015468.3	ENSMODP00000015185.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.70e-14	53.7	83	140

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++++++W+++  ++++ +G +P+n+++ ++
   Q: 83   PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNHNGEWCEA--QTKNGQGWVPSNYITPVN 140
           68899************************.***********..79999**********997 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MGQQPGKVLG DQRRPSLPAL HFIKGAGKKE SSRHGGPHCN VFVEHEALQR PVTASDFEPQ 60
GLSEAARWNS KENLLAGPSE NDPNLFVALY DFVASGDNTL SITKGEKLRV LGYNHNGEWC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGCAAC AGCCTGGAAA AGTCCTTGGG GACCAGAGAA GGCCAAGTTT GCCTGCCCTG 60
CACTTTATCA AAGGAGCAGG GAAAAAGGAA TCATCAAGGC ATGGGGGCCC ACACTGCAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR033221--ABL1
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001550	Ailuropoda melanoleuca	91.36	0.00e+00	1312.00
IUUC-Apl-003452	Anas platyrhynchos	90.62	0.00e+00	1221.00
IUUC-Aca-005312	Anolis carolinensis	86.56	0.00e+00	1176.00
IUUC-Ame-011903	Astyanax mexicanus	86.39	0.00e+00	1080.00
IUUC-Bta-012351	Bos taurus	90.52	0.00e+00	1254.00
IUUC-Cja-019491	Callithrix jacchus	90.56	0.00e+00	1334.00
IUUC-Cfa-021256	Canis familiaris	91.36	0.00e+00	1352.00
IUUC-Cpo-022046	Cavia porcellus	90.68	0.00e+00	1349.00
IUUC-Csa-023046	Chlorocebus sabaeus	90.52	0.00e+00	1263.00
IUUC-Dre-028190	Danio rerio	81.66	0.00e+00	1050.00
IUUC-Dno-029853	Dasypus novemcinctus	90.82	0.00e+00	1328.00
IUUC-Dor-030635	Dipodomys ordii	83.44	0.00e+00	1210.00
IUUC-Dme-032098	Drosophila melanogaster	74.27	0.00e+00	771.00
IUUC-Eca-033720	Equus caballus	90.95	0.00e+00	1249.00
IUUC-Eeu-035173	Erinaceus europaeus	85.81	0.00e+00	1227.00
IUUC-Fca-035967	Felis catus	91.08	0.00e+00	1323.00
IUUC-Fal-036723	Ficedula albicollis	90.50	0.00e+00	1223.00
IUUC-Gmo-039550	Gadus morhua	79.18	0.00e+00	1088.00
IUUC-Gga-040481	Gallus gallus	91.49	0.00e+00	1210.00
IUUC-Gac-041643	Gasterosteus aculeatus	78.43	0.00e+00	1091.00
IUUC-Ggo-045299	Gorilla gorilla	90.82	0.00e+00	1356.00
IUUC-Hsa-047033	Homo sapiens	96.10	9.00e-40	154.00
IUUC-Itr-047935	Ictidomys tridecemlineatus	90.28	0.00e+00	1217.00
IUUC-Lch-050530	Latimeria chalumnae	85.00	0.00e+00	1236.00
IUUC-Loc-052430	Lepisosteus oculatus	85.43	0.00e+00	1027.00
IUUC-Laf-053609	Loxodonta africana	91.07	0.00e+00	1314.00
IUUC-Mcc-055654	Macaca mulatta	91.09	0.00e+00	1360.00
IUUC-Meu-056488	Macropus eugenii	84.57	0.00e+00	1192.00
IUUC-Mga-059270	Meleagris gallopavo	91.62	0.00e+00	1243.00
IUUC-Mmr-060593	Microcebus murinus	90.45	0.00e+00	1276.00
IUUC-Mmu-064002	Mus musculus	89.64	0.00e+00	1332.00
IUUC-Mpu-066197	Mustela putorius furo	90.43	0.00e+00	1336.00
IUUC-Mlu-067255	Myotis lucifugus	90.81	0.00e+00	1228.00
IUUC-Nle-069977	Nomascus leucogenys	84.04	0.00e+00	1226.00
IUUC-Opr-070327	Ochotona princeps	82.18	0.00e+00	1093.00
IUUC-Ont-072307	Oreochromis niloticus	84.11	0.00e+00	1061.00
IUUC-Oan-073100	Ornithorhynchus anatinus	91.63	0.00e+00	1283.00
IUUC-Ocu-074892	Oryctolagus cuniculus	85.86	0.00e+00	1127.00
IUUC-Ola-087389	Oryzias latipes	83.66	0.00e+00	1046.00
IUUC-Oga-088145	Otolemur garnettii	90.81	0.00e+00	1230.00
IUUC-Oar-090432	Ovis aries	90.95	0.00e+00	1251.00
IUUC-Ptr-090800	Pan troglodytes	90.82	0.00e+00	1355.00
IUUC-Psi-093078	Pelodiscus sinensis	89.65	0.00e+00	1264.00
IUUC-Pma-094420	Petromyzon marinus	78.38	0.00e+00	891.00
IUUC-Pfo-096979	Poecilia formosa	86.06	0.00e+00	1025.00
IUUC-Pca-100874	Procavia capensis	98.95	0.00e+00	758.00
IUUC-Pva-102415	Pteropus vampyrus	91.21	0.00e+00	1348.00
IUUC-Rno-105682	Rattus norvegicus	89.77	0.00e+00	1317.00
IUUC-Sha-106711	Sarcophilus harrisii	95.75	0.00e+00	1300.00
IUUC-Ssc-115472	Sus scrofa	90.96	0.00e+00	1333.00
IUUC-Tgu-117037	Taeniopygia guttata	92.13	0.00e+00	1335.00
IUUC-Tru-118324	Takifugu rubripes	72.19	0.00e+00	1021.00
IUUC-Tsy-119216	Tarsius syrichta	95.08	0.00e+00	1145.00
IUUC-Tni-119950	Tetraodon nigroviridis	70.53	0.00e+00	995.00
IUUC-Ttr-128209	Tursiops truncatus	92.15	0.00e+00	1370.00
IUUC-Xtr-132477	Xenopus tropicalis	78.44	0.00e+00	1007.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence