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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046512
UUCD1 version UUC-HoS-00110
Ensembl Protein ID ENSP00000443492.2
UniProt Accession Q13309; A8K5E0; B4DJT4; Q8TDZ0; Q8TDZ1; Q9BV69; SKP2_HUMAN
Genbank Protein ID AAC50242.1; BAB87200.1; BAB87201.1; BAB87202.1; AAK31593.1; BAF83944.1; BAG58946.1; EAW55936.1; AAH01441.1; AAH07441.1
Protein Name S-phase kinase-associated protein 2; Cyclin-A/CDK2-associated protein p45; F-box protein Skp2; F-box/LRR-repeat protein 1; p45skp2
Genbank Nucleotide ID U33761; AB050979; AB050980; AB050981; AY029177; AK291255; AK296223; AC008942; BC001441; BC007441
Gene Name SKP2; FBXL1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000145604.15 ENST00000274254.9 ENSP00000274254.5
ENSG00000145604.15 ENST00000508514.5 ENSP00000421941.1
ENSG00000145604.15 ENST00000513151.5 ENSP00000423188.1
ENSG00000145604.15 ENST00000509692.5 ENSP00000426004.1
ENSG00000145604.15 ENST00000504386.1 ENSP00000424234.1
ENSG00000145604.15 ENST00000620197.4 ENSP00000478031.1
ENSG00000145604.15 ENST00000546211.5 ENSP00000443492.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Drug and target
TTDManually
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 16352731; 19828607; 19117950; 18056467; 19660140; 21237244; 18660753; 18665269; 10559858; 19451650; 19429855; 15520277; 17908926; 16286470; 14592976; 12840033; 16103164; 15113913; 19615363; 19935701; 16951159; 12769844; 18071316; 17786314
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 1.50e-05 26.8 106 151
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 101  glldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
            ++d+lp+e+l+ i++ l  +ell+++ vc+rw++las+++lw+t+
   Q: 106  VSWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTL 151
           57899**************************************997 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.
Protein Sequence
(Fasta)
MHVFTPGPAD AMHRKHLQEI PDLSSNVATS FTWGWDSSKT SELLSGMGVS ALEKEEPDSE 60
NIPQELLSNL GHPESPPRKR LKSKGSDKDF VIVRRPKLNR ENFPGVSWDS LPDELLLGIF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046512|E3,F-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAGGGAAGGA AGTAAGGGCG AGCCCGTCGG ACTACGAAGC GGGACGGAAA CTACAATTCC 60
CAGCAGGCCT TGGGCCTCAG TGCGGCCGCG AAGCAGAGCG GGCTGTAGAG CCTTGCGCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046512|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0433--Leucine-rich repeat
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
SMART

SM00256--FBOX
SM00367--LRR_CC
Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0042802--F:identical protein binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0008283--P:cell proliferation
GO:0071460--P:cellular response to cell-matrix adhesion
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0033148--P:positive regulation of intracellular estrogen receptor signaling pathway
GO:1902916--P:positive regulation of protein polyubiquitination
GO:0048661--P:positive regulation of smooth muscle cell proliferation
GO:0016579--P:protein deubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051726--P:regulation of cell cycle
KEGG hsa:6502
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002197 Ailuropoda melanoleuca 92.92 0.00e+00 778.00
IUUC-Atr-002711 Amborella trichopoda 25.00 1.00e-09 58.90
IUUC-Apl-003453 Anas platyrhynchos 68.17 7.00e-120 423.00
IUUC-Aca-005185 Anolis carolinensis 62.21 5.00e-141 494.00
IUUC-Ame-010665 Astyanax mexicanus 47.12 5.00e-91 328.00
IUUC-Bta-013450 Bos taurus 90.57 0.00e+00 795.00
IUUC-Bra-016626 Brassica rapa 23.46 9.00e-11 62.80
IUUC-Cel-018410 Caenorhabditis elegans 28.13 2.00e-26 113.00
IUUC-Cja-019834 Callithrix jacchus 96.70 0.00e+00 835.00
IUUC-Cfa-020401 Canis familiaris 91.74 0.00e+00 815.00
IUUC-Cpo-022183 Cavia porcellus 90.33 0.00e+00 790.00
IUUC-Csa-023418 Chlorocebus sabaeus 98.35 0.00e+00 848.00
IUUC-Cho-024412 Choloepus hoffmanni 88.14 1.00e-180 625.00
IUUC-Cin-025248 Ciona intestinalis 29.88 2.00e-39 156.00
IUUC-Csv-026189 Ciona savignyi 29.67 6.00e-37 148.00
IUUC-Cme-027297 Cyanidioschyzon merolae 37.14 2.00e-07 50.10
IUUC-Dre-028032 Danio rerio 47.59 3.00e-102 365.00
IUUC-Dno-029222 Dasypus novemcinctus 90.37 0.00e+00 801.00
IUUC-Dor-030505 Dipodomys ordii 86.16 2.00e-172 598.00
IUUC-Dme-031972 Drosophila melanogaster 33.72 5.00e-51 195.00
IUUC-Ete-032234 Echinops telfairi 82.59 2.00e-115 408.00
IUUC-Eca-033944 Equus caballus 91.97 0.00e+00 820.00
IUUC-Eeu-035008 Erinaceus europaeus 75.58 1.00e-119 422.00
IUUC-Fca-035412 Felis catus 91.75 0.00e+00 796.00
IUUC-Fal-037337 Ficedula albicollis 63.98 3.00e-139 488.00
IUUC-Gmo-038934 Gadus morhua 42.69 5.00e-39 155.00
IUUC-Gga-041152 Gallus gallus 67.06 7.00e-160 556.00
IUUC-Gac-041819 Gasterosteus aculeatus 46.37 2.00e-76 279.00
IUUC-Ggo-045479 Gorilla gorilla 99.72 0.00e+00 719.00
IUUC-Itr-048515 Ictidomys tridecemlineatus 91.89 0.00e+00 764.00
IUUC-Lch-050115 Latimeria chalumnae 57.76 1.00e-135 476.00
IUUC-Loc-052554 Lepisosteus oculatus 49.30 4.00e-105 374.00
IUUC-Laf-053563 Loxodonta africana 91.00 0.00e+00 750.00
IUUC-Mcc-055143 Macaca mulatta 96.11 0.00e+00 849.00
IUUC-Meu-056593 Macropus eugenii 56.40 9.00e-104 370.00
IUUC-Mga-060084 Meleagris gallopavo 59.77 2.00e-83 301.00
IUUC-Mmr-060660 Microcebus murinus 94.50 0.00e+00 842.00
IUUC-Mdo-062363 Monodelphis domestica 69.58 6.00e-161 560.00
IUUC-Mmu-063287 Mus musculus 86.32 0.00e+00 757.00
IUUC-Mpu-065791 Mustela putorius furo 91.28 0.00e+00 816.00
IUUC-Mlu-067714 Myotis lucifugus 88.47 0.00e+00 749.00
IUUC-Nle-069823 Nomascus leucogenys 99.53 0.00e+00 857.00
IUUC-Opr-071046 Ochotona princeps 72.27 3.00e-103 368.00
IUUC-Ont-071820 Oreochromis niloticus 45.93 1.00e-68 253.00
IUUC-Ocu-074868 Oryctolagus cuniculus 91.75 0.00e+00 796.00
IUUC-Ola-086608 Oryzias latipes 46.46 5.00e-74 271.00
IUUC-Oga-089044 Otolemur garnettii 93.87 0.00e+00 817.00
IUUC-Oar-089650 Ovis aries 90.37 0.00e+00 807.00
IUUC-Ptr-090743 Pan troglodytes 100.00 0.00e+00 862.00
IUUC-Pan-092501 Papio anubis 98.35 0.00e+00 849.00
IUUC-Psi-094032 Pelodiscus sinensis 68.48 3.00e-164 571.00
IUUC-Pfo-097279 Poecilia formosa 46.68 4.00e-63 235.00
IUUC-Pab-097821 Pongo abelii 99.44 0.00e+00 715.00
IUUC-Pca-100100 Procavia capensis 90.40 6.00e-178 616.00
IUUC-Pva-103181 Pteropus vampyrus 90.68 0.00e+00 629.00
IUUC-Rno-105091 Rattus norvegicus 88.15 0.00e+00 765.00
IUUC-Sha-107226 Sarcophilus harrisii 70.85 1.00e-167 582.00
IUUC-Ssc-115665 Sus scrofa 94.34 0.00e+00 821.00
IUUC-Tgu-116982 Taeniopygia guttata 63.51 2.00e-136 479.00
IUUC-Tru-118276 Takifugu rubripes 46.51 2.00e-74 272.00
IUUC-Tsy-119074 Tarsius syrichta 92.09 0.00e+00 664.00
IUUC-Tni-120702 Tetraodon nigroviridis 47.55 2.00e-51 196.00
IUUC-Tbe-127990 Tupaia belangeri 91.95 1.00e-159 555.00
IUUC-Ttr-128661 Tursiops truncatus 76.92 3.00e-111 395.00
IUUC-Xtr-132166 Xenopus tropicalis 57.28 6.00e-129 454.00
Created Date 25-Jun-2017

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