iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.10e-06	29.4	265	306

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+C e f  kd  ++lpC+H+fh+ C+  w         + +CP C+
   Q: 265  CAVCIENFkvKDVIRILPCKHIFHRICIDPW------LLDHRTCPMCK 306
           ********9988899****************......9999******6 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAARRRPAAG VGARDALAVL ALALCAPGVG GGALEWYSAT VSIEYVDPQS NLTVWSVTES 60
GRFGDSSLRE ERQGLVGVPR APADAEGCAP DTRFVAPGAL GNAPWVALVA RGGCTFKDKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGCGC GGCGGCGGCC CGCGGCTGGC GTGGGAGCCC GGGACGCGCT CGCGGTGCTT 60
GCGCTGGCCT TGTGTGCTCC CGGGGTGGGC GGCGGGGCAC TCGAGTGGTA CTCCGCCACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0732--Signal
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR003137--PA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF02225--PA
PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0016021--C:integral component of membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0035690--P:cellular response to drug
GO:0043409--P:negative regulation of MAPK cascade
GO:0031647--P:regulation of protein stability

KEGG

rno:363222

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001968	Ailuropoda melanoleuca	77.45	8.00e-161	559.00
IUUC-Apl-004109	Anas platyrhynchos	70.61	4.00e-100	357.00
IUUC-Bta-012340	Bos taurus	75.27	2.00e-155	541.00
IUUC-Cja-019566	Callithrix jacchus	75.14	2.00e-158	551.00
IUUC-Cfa-020289	Canis familiaris	80.17	8.00e-108	382.00
IUUC-Cpo-021916	Cavia porcellus	65.65	3.00e-75	274.00
IUUC-Csa-024084	Chlorocebus sabaeus	77.47	5.00e-159	553.00
IUUC-Cho-024305	Choloepus hoffmanni	78.64	5.00e-126	443.00
IUUC-Cgl-026578	Colletotrichum gloeosporioides	48.08	3.00e-12	66.60
IUUC-Dno-030098	Dasypus novemcinctus	77.33	1.00e-167	582.00
IUUC-Dor-030620	Dipodomys ordii	74.80	3.00e-143	501.00
IUUC-Ete-032306	Echinops telfairi	77.49	4.00e-157	547.00
IUUC-Fca-035950	Felis catus	79.34	1.00e-109	388.00
IUUC-Fal-037429	Ficedula albicollis	66.49	3.00e-132	464.00
IUUC-Fso-038141	Fusarium solani	41.86	2.00e-15	77.40
IUUC-Gga-041201	Gallus gallus	64.64	2.00e-130	459.00
IUUC-Ggo-045429	Gorilla gorilla	77.65	9.00e-156	542.00
IUUC-Hsa-046191	Homo sapiens	75.94	2.00e-159	555.00
IUUC-Itr-048018	Ictidomys tridecemlineatus	79.13	1.00e-148	519.00
IUUC-Kpa-049389	Komagataella pastoris	38.89	3.00e-10	59.30
IUUC-Lch-049498	Latimeria chalumnae	60.43	5.00e-130	457.00
IUUC-Laf-054239	Loxodonta africana	70.20	4.00e-124	437.00
IUUC-Meu-056382	Macropus eugenii	71.87	3.00e-145	508.00
IUUC-Mga-059435	Meleagris gallopavo	71.12	4.00e-68	250.00
IUUC-Mmr-061513	Microcebus murinus	78.02	4.00e-161	560.00
IUUC-Mdo-063028	Monodelphis domestica	71.39	6.00e-148	516.00
IUUC-Mmu-063545	Mus musculus	95.38	0.00e+00	660.00
IUUC-Mpu-066370	Mustela putorius furo	78.09	6.00e-161	560.00
IUUC-Mlu-067271	Myotis lucifugus	72.06	6.00e-128	450.00
IUUC-Nle-069207	Nomascus leucogenys	77.42	2.00e-161	561.00
IUUC-Opr-070704	Ochotona princeps	72.13	3.00e-94	337.00
IUUC-Oan-072837	Ornithorhynchus anatinus	67.96	5.00e-135	474.00
IUUC-Ocu-074671	Oryctolagus cuniculus	79.15	2.00e-120	424.00
IUUC-Oga-089083	Otolemur garnettii	77.33	2.00e-164	572.00
IUUC-Oar-089254	Ovis aries	76.61	7.00e-106	376.00
IUUC-Ptr-090940	Pan troglodytes	77.45	9.00e-160	556.00
IUUC-Pan-092636	Papio anubis	76.92	3.00e-158	551.00
IUUC-Psi-093435	Pelodiscus sinensis	74.36	5.00e-92	330.00
IUUC-Pab-098525	Pongo abelii	77.72	2.00e-156	545.00
IUUC-Pva-102395	Pteropus vampyrus	76.19	5.00e-162	563.00
IUUC-Pgr-103263	Puccinia graminis	42.47	1.00e-10	62.40
IUUC-Sha-107305	Sarcophilus harrisii	74.57	1.00e-97	348.00
IUUC-Ssc-115598	Sus scrofa	76.36	3.00e-153	534.00
IUUC-Tgu-116463	Taeniopygia guttata	65.92	7.00e-126	443.00
IUUC-Tsy-118915	Tarsius syrichta	76.73	4.00e-103	367.00
IUUC-Tme-126970	Tuber melanosporum	49.06	1.00e-12	68.20
IUUC-Tbe-127906	Tupaia belangeri	65.70	2.00e-79	288.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence