iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gga-040861

Ensembl Protein ID

ENSGALP00000004174.2

UniProt Accession

Q04929; CRK_CHICK

Genbank Protein ID

AAA49001.1

Protein Name

Adapter molecule crk; Proto-oncogene c-Crk; p38

Genbank Nucleotide ID

L08168

Gene Name

CRK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000002656.5	ENSGALT00000004183.4	ENSGALP00000004174.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.50e-18	66.8	136	191

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           e+v++l+d+++++d++L +kkGd++++   ++ +e W+++ ++  gkrG++P  +vek 
   Q: 136  EYVRALFDFNGNDDEDLPFKKGDILKI--RDKPEEQWWNA-EDMDGKRGMIPVPYVEKC 191
           79*************************..6999******9.5**************986 PP

Organism

Gallus gallus

Functional Description
(View)

May mediate attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. May regulate the EFNA5-EPHA3 signaling (By similarity).

Protein Sequence
(Fasta)

MAGQFDSEDR GSWYWGRLSR GDAVSLLQGQ RHGTFLVRDS GSIPGDFVLS VSESSRVSHY 60
IVNSLGPAGG RRAGGEGPGA PGLNPTRFRI GDQEFDSLPS LLEFYKIHYL DTTTLIEPVS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGAGCGGG GCACCGCGGG CTGCGGCGGC CCGCGGGGCG GGGGCAGCGA GTGCGGCCTG 60
CGGGTGGGGC GGCCCTCATG GCCGGGCAGT TCGACTCCGA GGACCGGGGG AGCTGGTACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0048013--P:ephrin receptor signaling pathway
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0043087--P:regulation of GTPase activity

KEGG

gga:107054794; gga:417553

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001192	Ailuropoda melanoleuca	84.00	1.00e-145	508.00
IUUC-Ame-011721	Astyanax mexicanus	65.20	4.00e-113	400.00
IUUC-Bta-012320	Bos taurus	83.93	3.00e-148	517.00
IUUC-Cja-019935	Callithrix jacchus	83.61	1.00e-151	528.00
IUUC-Cfa-021221	Canis familiaris	83.93	3.00e-148	517.00
IUUC-Cpo-021592	Cavia porcellus	79.66	2.00e-127	448.00
IUUC-Cho-024775	Choloepus hoffmanni	83.61	9.00e-149	518.00
IUUC-Dre-027390	Danio rerio	66.36	2.00e-115	408.00
IUUC-Dno-029847	Dasypus novemcinctus	83.93	3.00e-148	517.00
IUUC-Dor-030360	Dipodomys ordii	79.34	7.00e-141	492.00
IUUC-Eca-033233	Equus caballus	83.28	4.00e-147	513.00
IUUC-Fal-037152	Ficedula albicollis	94.31	1.00e-146	511.00
IUUC-Gmo-038849	Gadus morhua	64.04	3.00e-112	397.00
IUUC-Gac-041627	Gasterosteus aculeatus	62.42	1.00e-113	402.00
IUUC-Ggo-045475	Gorilla gorilla	83.93	3.00e-148	517.00
IUUC-Hsa-046008	Homo sapiens	83.93	3.00e-148	517.00
IUUC-Itr-048906	Ictidomys tridecemlineatus	81.30	2.00e-119	421.00
IUUC-Lch-050509	Latimeria chalumnae	79.35	2.00e-145	508.00
IUUC-Loc-052229	Lepisosteus oculatus	69.85	2.00e-104	371.00
IUUC-Laf-053896	Loxodonta africana	83.06	8.00e-151	525.00
IUUC-Mcc-055280	Macaca mulatta	83.93	3.00e-148	517.00
IUUC-Mdo-062691	Monodelphis domestica	80.84	4.00e-144	503.00
IUUC-Mmu-063691	Mus musculus	83.61	5.00e-148	516.00
IUUC-Mpu-065737	Mustela putorius furo	83.93	3.00e-148	517.00
IUUC-Mlu-067005	Myotis lucifugus	83.28	3.00e-147	513.00
IUUC-Opr-071114	Ochotona princeps	82.95	9.00e-150	522.00
IUUC-Ont-071877	Oreochromis niloticus	64.33	2.00e-117	414.00
IUUC-Oan-072967	Ornithorhynchus anatinus	81.99	9.00e-122	429.00
IUUC-Olo-080293	Oryza longistaminata	36.00	4.50e+00	24.60
IUUC-Oga-088266	Otolemur garnettii	83.61	3.00e-148	517.00
IUUC-Oar-089221	Ovis aries	81.64	1.00e-144	505.00
IUUC-Ptr-091463	Pan troglodytes	80.33	6.00e-138	483.00
IUUC-Pan-092242	Papio anubis	83.93	3.00e-148	517.00
IUUC-Pfo-097378	Poecilia formosa	62.19	1.00e-104	372.00
IUUC-Pab-097823	Pongo abelii	77.94	3.00e-87	313.00
IUUC-Pca-101068	Procavia capensis	83.93	3.00e-148	517.00
IUUC-Rno-105288	Rattus norvegicus	83.61	7.00e-148	515.00
IUUC-Sar-113453	Sorex araneus	76.72	6.00e-135	473.00
IUUC-Tgu-116926	Taeniopygia guttata	89.51	1.00e-156	544.00
IUUC-Tru-118656	Takifugu rubripes	64.53	1.00e-116	412.00
IUUC-Tni-120229	Tetraodon nigroviridis	61.49	1.00e-104	372.00
IUUC-Tbe-127436	Tupaia belangeri	80.33	4.00e-131	460.00
IUUC-Vpa-130527	Vicugna pacos	83.61	3.00e-146	510.00
IUUC-Xtr-131808	Xenopus tropicalis	81.31	1.00e-146	511.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence