iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093952

Ensembl Protein ID

ENSPSIP00000003674.1

UniProt Accession

K7F6L4; K7F6L4_PELSI

Genbank Protein ID

ENSPSIP00000003674

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGCU01076746

Gene Name

HECTD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000003486.1	ENSPSIT00000003694.1	ENSPSIP00000003674.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-79	267.5	3580	3941

Active Site

Position(s)	Description	Evidence
3915	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf........lysendketlqpnpdsglknpehlklFeflGrllgkal 82
           d ++ ++++f+gEe+++++G++r+fl++++kelq+++l+l+          ++++k+ l+p+p ++     +++l +f+G+llg+a+
   Q: 3580 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLllcpssavNKNKKGKYILTPSPITY----AEEQLLHFFGQLLGIAV 3662
           5667788********************************99999999855556699*********9....689************** PP
   S: 83   qdgrlldlplsksfyklllgkklsl.edleevdpelykslkeikena.esdieelgldltfs..vseei...............lge 150
           + + +l+l+l  sf+k+l+g++l+   dl+e d  +y+++k+i++ + e+++e+l+++++++  +  ++                 +
   Q: 3663 RADVPLPLDLLASFWKTLVGEPLDPdVDLQEADILTYNYVKKIENINdETELEALCAEIASQhlA--TEspdcpnkpcckftylSMT 3747
           *************************99************99999765367888888888888532..33469999*****9954334 PP
   S: 151  tkeeeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkyk 236
            +e+eL+p+G++ipV +eNk+ Y  ++ ++rl+e +   +++a+r+G+ ++ipl+ll+ +t+ e+el +cG ++i++e lk++t+y+
   Q: 3748 GEEVELCPRGRHIPVVWENKDIYATAIRNLRLRElQNPDCMTAVRAGLGSIIPLQLLTTLTPLEMELRTCGLPYINLEFLKAHTMYQ 3834
           45556*****************************9999************************************************* PP
   S: 237  ggytedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkL 310
            g++e++++i++Fw++le+f++ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d+r+++++TC++++kL
   Q: 3835 VGLMETDQHIEFFWSALEMFTQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgaaGSPDSRYIRVETCMFMIKL 3921
           **********************************************9999999998888888888*955555*************** PP
   S: 311  PeYsskeilkekLlyAieet 330
           P+Yss +i+ ekL+yA++++
   Q: 3922 PQYSSLDIMLEKLRYAVHYR 3941
           *****************986 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MPVNHFPVGS TMTTVHLSSD GTYFYWIWSP ASLNEKTPKG HSVFMDIFEL IEENDICIAS 60
PLQERIILMR KEGESAKSIN EMLLSRLSRY RASPSATLAA LTGSTISNTL KEDQAAANTS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCGGCCCAG TGGCTCTCGG TGAAGGAGGA GACCATCTTC CTGCACGACG GGCTGATCCG 60
GGTCACCGAC CTGGCCGAGC TGCCCAGCGA GATCATCGGG GTGGCCGAAC CCGCGGACAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	92.39	0.00e+00	5066.00
IUUC-Apl-004161	Anas platyrhynchos	92.44	0.00e+00	5185.00
IUUC-Aca-005341	Anolis carolinensis	89.35	0.00e+00	6620.00
IUUC-Ame-011574	Astyanax mexicanus	79.05	0.00e+00	4341.00
IUUC-Bta-012514	Bos taurus	85.11	0.00e+00	1754.00
IUUC-Cja-019148	Callithrix jacchus	89.22	0.00e+00	4863.00
IUUC-Cfa-020499	Canis familiaris	90.74	0.00e+00	5056.00
IUUC-Cpo-021894	Cavia porcellus	93.27	0.00e+00	2627.00
IUUC-Csa-023079	Chlorocebus sabaeus	89.26	0.00e+00	6719.00
IUUC-Cho-024415	Choloepus hoffmanni	88.20	0.00e+00	4747.00
IUUC-Dre-027452	Danio rerio	77.25	0.00e+00	4376.00
IUUC-Dno-029595	Dasypus novemcinctus	88.98	0.00e+00	6724.00
IUUC-Dor-030849	Dipodomys ordii	93.24	0.00e+00	1742.00
IUUC-Ete-032563	Echinops telfairi	84.49	0.00e+00	1102.00
IUUC-Eca-034202	Equus caballus	92.64	0.00e+00	5060.00
IUUC-Eeu-035175	Erinaceus europaeus	92.24	0.00e+00	1001.00
IUUC-Fca-036295	Felis catus	90.55	0.00e+00	4825.00
IUUC-Fal-037003	Ficedula albicollis	90.97	0.00e+00	6187.00
IUUC-Gmo-038579	Gadus morhua	82.63	0.00e+00	2728.00
IUUC-Gga-040961	Gallus gallus	91.51	0.00e+00	6992.00
IUUC-Gac-041899	Gasterosteus aculeatus	82.58	0.00e+00	2768.00
IUUC-Ggo-045099	Gorilla gorilla	90.62	0.00e+00	5922.00
IUUC-Hsa-046331	Homo sapiens	89.36	0.00e+00	6771.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	86.23	0.00e+00	1970.00
IUUC-Lch-049923	Latimeria chalumnae	85.86	0.00e+00	2661.00
IUUC-Loc-052630	Lepisosteus oculatus	85.57	0.00e+00	2524.00
IUUC-Laf-053394	Loxodonta africana	90.53	0.00e+00	5031.00
IUUC-Mcc-055763	Macaca mulatta	89.23	0.00e+00	6717.00
IUUC-Meu-056039	Macropus eugenii	85.49	0.00e+00	4899.00
IUUC-Mga-059500	Meleagris gallopavo	92.31	0.00e+00	7012.00
IUUC-Mmr-060868	Microcebus murinus	85.65	0.00e+00	6455.00
IUUC-Mdo-062772	Monodelphis domestica	89.85	0.00e+00	6864.00
IUUC-Mmu-063606	Mus musculus	89.81	0.00e+00	5011.00
IUUC-Mpu-065860	Mustela putorius furo	89.54	0.00e+00	4926.00
IUUC-Mlu-067376	Myotis lucifugus	92.39	0.00e+00	5054.00
IUUC-Nle-069693	Nomascus leucogenys	89.20	0.00e+00	6660.00
IUUC-Opr-071065	Ochotona princeps	88.52	0.00e+00	1144.00
IUUC-Ont-072470	Oreochromis niloticus	81.23	0.00e+00	4489.00
IUUC-Oan-073693	Ornithorhynchus anatinus	92.67	0.00e+00	3286.00
IUUC-Ocu-074032	Oryctolagus cuniculus	88.35	0.00e+00	6729.00
IUUC-Ola-087433	Oryzias latipes	82.48	0.00e+00	1567.00
IUUC-Oga-088546	Otolemur garnettii	89.82	0.00e+00	6454.00
IUUC-Oar-089643	Ovis aries	86.52	0.00e+00	699.00
IUUC-Ptr-090504	Pan troglodytes	90.40	0.00e+00	6786.00
IUUC-Pan-092543	Papio anubis	89.21	0.00e+00	6713.00
IUUC-Pfo-096356	Poecilia formosa	79.86	0.00e+00	4443.00
IUUC-Pab-098240	Pongo abelii	89.21	0.00e+00	6712.00
IUUC-Pca-100994	Procavia capensis	93.25	0.00e+00	2898.00
IUUC-Pva-102263	Pteropus vampyrus	91.28	0.00e+00	4972.00
IUUC-Rno-104888	Rattus norvegicus	88.07	0.00e+00	6676.00
IUUC-Sha-106944	Sarcophilus harrisii	90.36	0.00e+00	6925.00
IUUC-Sar-113556	Sorex araneus	82.67	0.00e+00	901.00
IUUC-Ssc-116187	Sus scrofa	92.85	0.00e+00	3087.00
IUUC-Tgu-116655	Taeniopygia guttata	91.70	0.00e+00	5113.00
IUUC-Tru-118093	Takifugu rubripes	81.20	0.00e+00	2868.00
IUUC-Tni-119739	Tetraodon nigroviridis	82.70	0.00e+00	1599.00
IUUC-Tbe-127962	Tupaia belangeri	79.77	0.00e+00	1086.00
IUUC-Ttr-128819	Tursiops truncatus	82.24	0.00e+00	2559.00
IUUC-Vpa-130482	Vicugna pacos	91.05	0.00e+00	4240.00
IUUC-Xtr-132222	Xenopus tropicalis	86.45	0.00e+00	6497.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence