iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Dme-032119

UUCD1 version

UUC-DrM-00550

Ensembl Protein ID

FBpp0076806

UniProt Accession

Q9VRP5; M9NE30; Q7YTX7; Q86NM9; Q8IQ57; Q8IQ58; Q8IQ59; Q8IQ60; Q960Q4; UBP36_DROME

Genbank Protein ID

AAN12107.1; AAN12108.2; AAN12109.1; AAN12110.2; AAN12111.1; AFH04310.1; AFH04311.1; AAK93340.1; AAO42671.1; AAQ22589.1; ACI47091.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 36; Deubiquitinating enzyme 36; Protein scrawny; Ubiquitin thioesterase 36; Ubiquitin-specific-processing protease 36

Genbank Nucleotide ID

AE014296; AE014296; AE014296; AE014296; AE014296; AE014296; AE014296; AY051916; BT004507; BT010120; BT046169

Gene Name

scny; Usp36; CG5505

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0260936	FBtr0077101	FBpp0076807
FBgn0260936	FBtr0307976	FBpp0300345
FBgn0260936	FBtr0077103	FBpp0076809
FBgn0260936	FBtr0330128	FBpp0303161
FBgn0260936	FBtr0077100	FBpp0076806
FBgn0260936	FBtr0330127	FBpp0303160

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	19837371

Classification

Family	E-value	Score	Start	End
DUB/USP	8.20e-73	245.5	172	478

Active Site

Position(s)	Description	Evidence
181	Nucleophile
439	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaf 98
           tG+ N+gNtCY+NS+LQ+L++ip l++ l +++ +  + +  +  +g+++++++k + +  +s+++av p  ++++lk++ +++   +q+Da+Efl+f
   Q: 172  TGMINVGNTCYLNSTLQALLHIPALANWLVSEQAHLADCNVAEPGSGCIICAMTKTLLAT-QSNQSAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRF 268
           7******************************5555555555567899*********9777.9************************************ PP
   S: 99   lldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftk 196
           l++++e++         +++         + +e ++  k+++++ ++F+g l+s+++cl+c++vs +++ f+dl l++++ +     sl+d++e  ++
   Q: 269  LVEAMERAY-------LMRF--------RNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKAD-----SLEDAFEGHFS 346
           *******99.......2333........34456778999*******************************************.....9********** PP
   S: 197  eeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssG 293
           +e+le +  y+ce ckkk+ a+k+++l++ P +L+++LkRf      +  +k++k+++f+ ++dls++ ++++ +q+++ +Y+L+++v H G s ++G
   Q: 347  RERLE-DMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRF-----SMIGNKLTKQISFKSRIDLSKYAARSQAAQAQPLTYRLVSMVTHLGaSQHCG 438
           ****9.577********************************.....46789*********************************************** PP
   S: 294  HYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYk 336
           HY+a+   ++g++++fdDs+V+++ +++v++   ++aY++f++
   Q: 439  HYTAIGSTDTGSFYNFDDSYVRPIAMHSVCN---TNAYIMFFE 478
           *******************************...*******97 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4).

Protein Sequence
(Fasta)

MPVSMAVCET ANVVNAALRE SLGGNSSAGS STDQAKSGED TNGSLQNHIV ANAKRILMAK 60
IEYEEVPNYH ESVLENLKSK YIVIKPGNPG AINGFSGKNN TGKLVGANGH DNNGARKQAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTTTTATT GTTAAGAAAA CATCGAAATA CATTTTTGTA AATATCGTGA AATGCTTTAG 60
GACATTTCGA GAGGCCTATC GCGTCACTTG GCCACTCGCG AGTTGGCATC CCCAAATGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0030718--P:germ-line stem cell population maintenance
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:1900425--P:negative regulation of defense response to bacterium
GO:0045824--P:negative regulation of innate immune response
GO:0031937--P:positive regulation of chromatin silencing
GO:1902459--P:positive regulation of stem cell population maintenance
GO:0016579--P:protein deubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0035019--P:somatic stem cell population maintenance
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG5505

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001055	Aegilops tauschii	31.69	3.00e-42	166.00
IUUC-Aml-002092	Ailuropoda melanoleuca	35.15	5.00e-62	232.00
IUUC-Atr-003102	Amborella trichopoda	34.18	9.00e-50	191.00
IUUC-Apl-003459	Anas platyrhynchos	34.96	2.00e-55	210.00
IUUC-Aca-005360	Anolis carolinensis	34.66	9.00e-68	251.00
IUUC-Aly-006389	Arabidopsis lyrata	36.71	3.00e-49	189.00
IUUC-Ath-006710	Arabidopsis thaliana	36.78	2.00e-49	190.00
IUUC-Ago-007836	Ashbya gossypii	29.86	3.00e-34	139.00
IUUC-Ame-011358	Astyanax mexicanus	36.49	2.00e-67	250.00
IUUC-Bta-013047	Bos taurus	33.13	1.00e-65	244.00
IUUC-Bdi-014036	Brachypodium distachyon	36.16	8.00e-49	188.00
IUUC-Bol-015996	Brassica oleracea	36.71	6.00e-52	198.00
IUUC-Bra-017156	Brassica rapa	36.88	6.00e-52	198.00
IUUC-Cja-019203	Callithrix jacchus	33.73	9.00e-63	234.00
IUUC-Cfa-020586	Canis familiaris	33.68	5.00e-62	232.00
IUUC-Cpo-021804	Cavia porcellus	32.85	9.00e-63	234.00
IUUC-Cre-022988	Chlamydomonas reinhardtii	36.61	3.00e-32	130.00
IUUC-Csa-023137	Chlorocebus sabaeus	34.68	2.00e-66	246.00
IUUC-Cho-024575	Choloepus hoffmanni	30.86	6.00e-38	152.00
IUUC-Cin-025230	Ciona intestinalis	39.62	1.00e-59	222.00
IUUC-Cne-027049	Cryptococcus neoformans	29.78	3.00e-30	125.00
IUUC-Cme-027339	Cyanidioschyzon merolae	34.20	6.00e-45	174.00
IUUC-Dre-028587	Danio rerio	32.62	2.00e-64	240.00
IUUC-Dno-029149	Dasypus novemcinctus	32.91	4.00e-61	229.00
IUUC-Dor-030836	Dipodomys ordii	28.81	4.00e-48	186.00
IUUC-Ete-033088	Echinops telfairi	31.44	6.00e-51	195.00
IUUC-Eca-033600	Equus caballus	33.40	3.00e-61	229.00
IUUC-Eeu-035019	Erinaceus europaeus	32.69	8.00e-40	156.00
IUUC-Fca-035792	Felis catus	34.60	9.00e-63	234.00
IUUC-Fal-037075	Ficedula albicollis	35.64	2.00e-61	230.00
IUUC-Gmo-039033	Gadus morhua	33.49	3.00e-62	233.00
IUUC-Gga-040504	Gallus gallus	36.06	1.00e-62	234.00
IUUC-Gac-042176	Gasterosteus aculeatus	32.86	2.00e-63	236.00
IUUC-Gma-044075	Glycine max	34.70	3.00e-45	176.00
IUUC-Ggo-045437	Gorilla gorilla	34.68	2.00e-60	227.00
IUUC-Hsa-046863	Homo sapiens	34.68	2.00e-60	226.00
IUUC-Hvu-047620	Hordeum vulgare	31.38	4.00e-45	176.00
IUUC-Itr-048655	Ictidomys tridecemlineatus	33.76	4.00e-67	249.00
IUUC-Lch-049867	Latimeria chalumnae	38.28	3.00e-69	256.00
IUUC-Lpe-051574	Leersia perrieri	33.92	1.00e-45	177.00
IUUC-Loc-052796	Lepisosteus oculatus	33.25	8.00e-59	221.00
IUUC-Laf-054243	Loxodonta africana	34.52	4.00e-61	229.00
IUUC-Mcc-055762	Macaca mulatta	34.68	2.00e-66	246.00
IUUC-Meu-056697	Macropus eugenii	33.96	2.00e-60	226.00
IUUC-Mtr-058396	Medicago truncatula	33.33	6.00e-46	177.00
IUUC-Mla-059049	Melampsora laricipopulina	36.09	6.00e-42	164.00
IUUC-Mga-059501	Meleagris gallopavo	36.34	6.00e-55	208.00
IUUC-Mvi-060547	Microbotryum violaceum	34.25	1.00e-57	217.00
IUUC-Mmr-060966	Microcebus murinus	34.99	3.00e-61	229.00
IUUC-Mdo-062733	Monodelphis domestica	33.97	3.00e-59	223.00
IUUC-Mmu-064331	Mus musculus	34.23	4.00e-64	239.00
IUUC-Mac-065039	Musa acuminata	34.38	1.00e-46	181.00
IUUC-Mpu-065759	Mustela putorius furo	34.17	4.00e-61	229.00
IUUC-Mlu-067371	Myotis lucifugus	33.62	4.00e-64	239.00
IUUC-Nle-070087	Nomascus leucogenys	33.33	1.00e-57	217.00
IUUC-Opr-070729	Ochotona princeps	28.82	1.00e-53	204.00
IUUC-Ont-071346	Oreochromis niloticus	33.33	7.00e-64	238.00
IUUC-Oan-072931	Ornithorhynchus anatinus	33.48	6.00e-69	255.00
IUUC-Ocu-074823	Oryctolagus cuniculus	29.69	6.00e-59	222.00
IUUC-Oba-075866	Oryza barthii	32.70	2.00e-49	189.00
IUUC-Obr-076408	Oryza brachyantha	34.33	2.00e-46	180.00
IUUC-Ogl-077239	Oryza glaberrima	32.70	3.00e-49	189.00
IUUC-Ogu-078064	Oryza glumaepatula	32.70	4.00e-49	189.00
IUUC-Oin-079157	Oryza indica	32.70	2.00e-49	189.00
IUUC-Olo-080231	Oryza longistaminata	32.30	4.00e-43	169.00
IUUC-Ome-081746	Oryza meridionalis	33.02	5.00e-49	189.00
IUUC-Oni-082339	Oryza nivara	32.70	3.00e-49	189.00
IUUC-Opu-083194	Oryza punctata	36.48	1.00e-47	185.00
IUUC-Oru-085083	Oryza rufipogon	32.70	2.00e-49	190.00
IUUC-Osa-086180	Oryza sativa	32.70	2.00e-49	190.00
IUUC-Ola-087255	Oryzias latipes	33.33	1.00e-63	237.00
IUUC-Oga-088818	Otolemur garnettii	34.29	9.00e-62	231.00
IUUC-Oar-089410	Ovis aries	32.64	8.00e-65	241.00
IUUC-Ptr-090680	Pan troglodytes	34.68	2.00e-60	227.00
IUUC-Pan-092482	Papio anubis	34.68	3.00e-66	246.00
IUUC-Psi-093277	Pelodiscus sinensis	35.95	4.00e-64	239.00
IUUC-Ppa-095853	Physcomitrella patens	38.23	8.00e-52	198.00
IUUC-Pfo-096807	Poecilia formosa	32.86	6.00e-64	238.00
IUUC-Pab-098724	Pongo abelii	34.68	5.00e-66	245.00
IUUC-Pop-098875	Populus trichocarpa	37.18	4.00e-48	185.00
IUUC-Pca-100117	Procavia capensis	35.58	7.00e-41	162.00
IUUC-Ppe-101980	Prunus persica	33.61	2.00e-48	186.00
IUUC-Pva-102883	Pteropus vampyrus	30.24	2.00e-47	183.00
IUUC-Pgr-103270	Puccinia graminis	37.65	9.00e-52	197.00
IUUC-Ptt-103887	Puccinia triticina	36.27	1.00e-50	193.00
IUUC-Rno-105340	Rattus norvegicus	34.44	1.00e-61	231.00
IUUC-Sha-107019	Sarcophilus harrisii	32.08	1.00e-59	224.00
IUUC-Sja-107805	Schizosaccharomyces japonicus	32.46	2.00e-49	188.00
IUUC-Spo-108119	Schizosaccharomyces pombe	33.88	2.00e-53	202.00
IUUC-Ssl-108506	Sclerotinia sclerotiorum	26.42	6.00e-22	98.20
IUUC-Smo-108727	Selaginella moellendorffii	36.39	5.00e-45	173.00
IUUC-Sit-109895	Setaria italica	33.79	1.00e-49	191.00
IUUC-Sly-111085	Solanum lycopersicum	36.79	1.00e-39	157.00
IUUC-Stu-111972	Solanum tuberosum	36.16	7.00e-45	174.00
IUUC-Sar-113340	Sorex araneus	35.93	1.00e-62	234.00
IUUC-Sbi-114477	Sorghum bicolor	36.08	2.00e-48	187.00
IUUC-Sre-114924	Sporisorium reilianum	35.75	6.00e-55	208.00
IUUC-Ssc-116022	Sus scrofa	33.49	2.00e-63	236.00
IUUC-Tgu-116976	Taeniopygia guttata	37.94	1.00e-56	212.00
IUUC-Tru-118391	Takifugu rubripes	32.38	2.00e-64	240.00
IUUC-Tsy-118974	Tarsius syrichta	35.61	9.00e-66	244.00
IUUC-Tni-120064	Tetraodon nigroviridis	32.38	7.00e-64	238.00
IUUC-Tca-120936	Theobroma cacao	34.82	5.00e-48	185.00
IUUC-Tae-122827	Triticum aestivum	36.48	2.00e-48	187.00
IUUC-Tur-126014	Triticum urartu	35.13	1.00e-44	174.00
IUUC-Tbe-128006	Tupaia belangeri	31.02	2.00e-23	104.00
IUUC-Ttr-129259	Tursiops truncatus	29.84	4.00e-46	179.00
IUUC-Uma-129416	Ustilago maydis	35.21	1.00e-54	207.00
IUUC-Vvi-131130	Vitis vinifera	36.79	9.00e-50	191.00
IUUC-Xtr-132544	Xenopus tropicalis	36.53	2.00e-58	219.00
IUUC-Xma-133735	Xiphophorus maculatus	32.86	3.00e-64	239.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence