iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062643

UUCD1 version

UUC-MoD-00597

Ensembl Protein ID

ENSMODP00000001964.2

UniProt Accession

F7BAJ5; F7BAJ5_MONDO

Protein Name

Uncharacterized protein

Gene Name

MDM4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000001605.3	ENSMODT00000002006.3	ENSMODP00000001964.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	76.06	0.00e+00	720.00	IUUC-Hsa-046950

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MSLSPTSTHC SASENACKIS PGQVNQVRPK LPLLKILQAA GAHGEMFTMK EVMHYLGQYI 60
MVKQLYDQQE QHMVYCGGDL LGELLGLQSF SVKDPSPLYD MLRKNLVTAT VFSFCFTHRL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAGGTGAACA GAGGAGGGCC GAGCTCGGAG GACTTTGGCT CTACTCTATG GTAGGGACAG 60
GCAGTAAGAC TACAAGAGAG CGGTCATTCT AGCAGCTGCC GCAGATCTAC TCTATGACCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR001370--BIR_rpt
IPR015458--MDM4
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:0071456--P:cellular response to hypoxia
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0045023--P:G0 to G1 transition
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0042177--P:negative regulation of protein catabolic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006461--P:protein complex assembly
GO:0050821--P:protein stabilization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001467	Ailuropoda melanoleuca	75.90	0.00e+00	666.00
IUUC-Apl-003800	Anas platyrhynchos	62.17	4.00e-163	567.00
IUUC-Aca-004608	Anolis carolinensis	55.84	1.00e-140	493.00
IUUC-Ame-010869	Astyanax mexicanus	48.61	8.00e-113	400.00
IUUC-Bta-013287	Bos taurus	74.45	0.00e+00	709.00
IUUC-Cja-019305	Callithrix jacchus	75.25	0.00e+00	678.00
IUUC-Cfa-020393	Canis familiaris	76.31	0.00e+00	684.00
IUUC-Cpo-022166	Cavia porcellus	74.79	0.00e+00	630.00
IUUC-Csa-023654	Chlorocebus sabaeus	76.06	0.00e+00	662.00
IUUC-Cho-024403	Choloepus hoffmanni	74.91	3.00e-104	372.00
IUUC-Dre-027754	Danio rerio	49.60	5.00e-121	427.00
IUUC-Dno-029630	Dasypus novemcinctus	74.30	0.00e+00	694.00
IUUC-Dor-031064	Dipodomys ordii	73.35	5.00e-141	494.00
IUUC-Ete-032901	Echinops telfairi	69.01	0.00e+00	655.00
IUUC-Eca-034234	Equus caballus	77.46	0.00e+00	773.00
IUUC-Eeu-035015	Erinaceus europaeus	66.49	3.00e-75	275.00
IUUC-Fca-036587	Felis catus	76.46	0.00e+00	697.00
IUUC-Fal-036906	Ficedula albicollis	55.85	5.00e-146	511.00
IUUC-Gmo-038646	Gadus morhua	44.64	8.00e-104	370.00
IUUC-Gga-040124	Gallus gallus	63.53	1.00e-126	446.00
IUUC-Gac-042397	Gasterosteus aculeatus	47.90	8.00e-117	414.00
IUUC-Ggo-045505	Gorilla gorilla	75.65	0.00e+00	676.00
IUUC-Hsa-046950	Homo sapiens	76.06	0.00e+00	679.00
IUUC-Itr-048886	Ictidomys tridecemlineatus	75.86	0.00e+00	689.00
IUUC-Lch-050141	Latimeria chalumnae	53.85	3.00e-132	465.00
IUUC-Loc-051921	Lepisosteus oculatus	48.44	2.00e-121	428.00
IUUC-Laf-054281	Loxodonta africana	74.95	0.00e+00	676.00
IUUC-Mcc-055462	Macaca mulatta	72.69	6.00e-177	613.00
IUUC-Meu-056294	Macropus eugenii	81.58	2.00e-172	598.00
IUUC-Mga-059924	Meleagris gallopavo	62.05	2.00e-174	605.00
IUUC-Mmr-061428	Microcebus murinus	74.85	0.00e+00	710.00
IUUC-Mmu-063229	Mus musculus	71.37	0.00e+00	685.00
IUUC-Mpu-065782	Mustela putorius furo	74.55	0.00e+00	672.00
IUUC-Mlu-068105	Myotis lucifugus	68.47	0.00e+00	656.00
IUUC-Nle-069549	Nomascus leucogenys	75.86	0.00e+00	678.00
IUUC-Opr-070568	Ochotona princeps	76.43	0.00e+00	663.00
IUUC-Ont-072276	Oreochromis niloticus	48.18	2.00e-123	435.00
IUUC-Oan-072787	Ornithorhynchus anatinus	76.79	0.00e+00	707.00
IUUC-Ocu-074912	Oryctolagus cuniculus	76.26	0.00e+00	706.00
IUUC-Ola-087037	Oryzias latipes	46.94	4.00e-108	384.00
IUUC-Oga-088953	Otolemur garnettii	74.65	0.00e+00	678.00
IUUC-Oar-089202	Ovis aries	75.05	0.00e+00	718.00
IUUC-Ptr-090964	Pan troglodytes	75.65	0.00e+00	676.00
IUUC-Pan-091975	Papio anubis	75.86	0.00e+00	675.00
IUUC-Psi-093558	Pelodiscus sinensis	65.31	1.00e-173	602.00
IUUC-Pfo-096454	Poecilia formosa	48.59	4.00e-122	431.00
IUUC-Pab-098123	Pongo abelii	76.06	0.00e+00	679.00
IUUC-Pca-101112	Procavia capensis	65.45	3.00e-175	608.00
IUUC-Pva-103098	Pteropus vampyrus	68.41	0.00e+00	645.00
IUUC-Rno-105930	Rattus norvegicus	72.43	0.00e+00	677.00
IUUC-Sha-107512	Sarcophilus harrisii	90.12	0.00e+00	773.00
IUUC-Sar-113584	Sorex araneus	69.23	4.00e-175	607.00
IUUC-Tgu-116766	Taeniopygia guttata	59.69	2.00e-108	385.00
IUUC-Tru-117829	Takifugu rubripes	49.09	3.00e-120	425.00
IUUC-Tsy-119268	Tarsius syrichta	74.36	2.00e-90	325.00
IUUC-Tni-120204	Tetraodon nigroviridis	47.18	9.00e-115	407.00
IUUC-Tbe-127840	Tupaia belangeri	72.38	8.00e-103	367.00
IUUC-Ttr-128863	Tursiops truncatus	75.45	0.00e+00	703.00
IUUC-Vpa-130718	Vicugna pacos	77.07	0.00e+00	676.00
IUUC-Xtr-132320	Xenopus tropicalis	47.07	1.00e-92	333.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence