iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.60e-08	33.5	220	270

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..........kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+C + +          ++ ++ l+C+Hvfh+ C+  w    +   k+++CP+C+
   Q: 220  CAVCGNQLlvsekeegviEN-TYKLSCNHVFHEFCIRGW----CIVGKKQTCPYCK 270
           ******99999987777555.889***************....889999******7 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MHQEHMDLHE PVDLNKSLDE MTPEERMRAQ HQLMVEKHRG HDAMHSEMVI ILFVTLVIAQ 60
IILVEWKKRH YRSYAFVTLL AMWLIPLIIS CSFGWLRFII IWLVFTCITA LVMRRAISKP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTTGGCCTC GAACGTTTCG TTTTCGATAA TCAGAAAGCG CTGTCGTAGC TAAAGTAAAT 60
AAAGGTTATG ATAAAATAGC AACAATTTGG GAAAAACCCC ATACTCAGGA CAGCTGGTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

dme:Dmel_CG15814

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002350	Ailuropoda melanoleuca	59.67	3.00e-110	390.00
IUUC-Apl-003882	Anas platyrhynchos	54.76	2.00e-91	327.00
IUUC-Aca-004343	Anolis carolinensis	60.87	9.00e-16	73.60
IUUC-Ame-010680	Astyanax mexicanus	58.12	5.00e-111	393.00
IUUC-Bta-013045	Bos taurus	61.36	2.00e-108	384.00
IUUC-Bci-013713	Botrytis cinerea	37.93	3.00e-07	48.50
IUUC-Cel-018296	Caenorhabditis elegans	52.87	6.00e-101	359.00
IUUC-Cja-019866	Callithrix jacchus	59.34	2.00e-110	390.00
IUUC-Cfa-021176	Canis familiaris	59.80	1.00e-109	388.00
IUUC-Cpo-022268	Cavia porcellus	60.33	3.00e-110	390.00
IUUC-Cre-022649	Chlamydomonas reinhardtii	41.11	1.00e-51	195.00
IUUC-Csa-023727	Chlorocebus sabaeus	60.00	7.00e-111	392.00
IUUC-Cho-025016	Choloepus hoffmanni	60.66	2.00e-111	394.00
IUUC-Cin-025281	Ciona intestinalis	54.31	3.00e-107	380.00
IUUC-Csv-026338	Ciona savignyi	57.64	5.00e-98	349.00
IUUC-Dre-027836	Danio rerio	59.67	1.00e-102	365.00
IUUC-Dno-029737	Dasypus novemcinctus	59.55	3.00e-109	387.00
IUUC-Dor-031070	Dipodomys ordii	56.29	2.00e-94	338.00
IUUC-Ete-032964	Echinops telfairi	55.08	3.00e-103	367.00
IUUC-Eca-034398	Equus caballus	60.00	7.00e-111	392.00
IUUC-Eeu-035318	Erinaceus europaeus	50.00	4.00e-86	310.00
IUUC-Fca-035807	Felis catus	59.49	1.00e-109	388.00
IUUC-Fal-036721	Ficedula albicollis	61.46	5.00e-107	379.00
IUUC-Gmo-039699	Gadus morhua	60.66	5.00e-104	370.00
IUUC-Gga-040840	Gallus gallus	60.96	9.00e-107	378.00
IUUC-Gac-042639	Gasterosteus aculeatus	58.18	3.00e-101	360.00
IUUC-Ggo-045576	Gorilla gorilla	60.00	5.00e-111	393.00
IUUC-Hsa-046468	Homo sapiens	60.00	5.00e-111	393.00
IUUC-Itr-049039	Ictidomys tridecemlineatus	56.07	1.00e-108	385.00
IUUC-Lch-050207	Latimeria chalumnae	56.03	6.00e-95	339.00
IUUC-Loc-052172	Lepisosteus oculatus	61.31	1.00e-112	398.00
IUUC-Laf-053879	Loxodonta africana	59.67	1.00e-110	392.00
IUUC-Mcc-055492	Macaca mulatta	60.00	7.00e-111	392.00
IUUC-Meu-055976	Macropus eugenii	51.48	5.00e-86	309.00
IUUC-Mga-059989	Meleagris gallopavo	60.78	2.00e-110	390.00
IUUC-Mmr-060894	Microcebus murinus	60.00	7.00e-111	392.00
IUUC-Mdo-061826	Monodelphis domestica	60.33	3.00e-108	384.00
IUUC-Mmu-063717	Mus musculus	59.67	4.00e-110	390.00
IUUC-Mpu-066826	Mustela putorius furo	60.00	7.00e-111	392.00
IUUC-Mlu-068081	Myotis lucifugus	57.73	7.00e-107	379.00
IUUC-Nle-069734	Nomascus leucogenys	60.00	7.00e-111	392.00
IUUC-Opr-070379	Ochotona princeps	61.30	6.00e-107	379.00
IUUC-Ont-071855	Oreochromis niloticus	59.12	6.00e-102	363.00
IUUC-Ocu-074363	Oryctolagus cuniculus	60.00	2.00e-110	390.00
IUUC-Ola-086489	Oryzias latipes	57.86	9.00e-101	358.00
IUUC-Oga-088323	Otolemur garnettii	59.80	2.00e-109	387.00
IUUC-Oar-090243	Ovis aries	60.00	1.00e-110	391.00
IUUC-Ptr-091374	Pan troglodytes	60.00	5.00e-111	393.00
IUUC-Pan-092115	Papio anubis	60.00	7.00e-111	392.00
IUUC-Psi-093658	Pelodiscus sinensis	60.47	5.00e-102	363.00
IUUC-Pfo-097261	Poecilia formosa	57.63	2.00e-100	358.00
IUUC-Pab-098579	Pongo abelii	60.00	5.00e-111	393.00
IUUC-Pca-100119	Procavia capensis	56.27	4.00e-99	353.00
IUUC-Pva-102111	Pteropus vampyrus	60.00	1.00e-110	391.00
IUUC-Rno-105364	Rattus norvegicus	59.67	5.00e-110	389.00
IUUC-Sha-107005	Sarcophilus harrisii	60.26	3.00e-111	394.00
IUUC-Ssl-108490	Sclerotinia sclerotiorum	34.21	1.00e-06	47.00
IUUC-Sar-113163	Sorex araneus	60.00	9.00e-111	392.00
IUUC-Ssc-115633	Sus scrofa	59.48	5.00e-109	386.00
IUUC-Tgu-116869	Taeniopygia guttata	61.22	9.00e-108	382.00
IUUC-Tru-118217	Takifugu rubripes	56.97	1.00e-107	381.00
IUUC-Tsy-119308	Tarsius syrichta	60.33	7.00e-111	392.00
IUUC-Tni-119882	Tetraodon nigroviridis	57.10	2.00e-107	380.00
IUUC-Tbe-127912	Tupaia belangeri	58.78	4.00e-86	310.00
IUUC-Ttr-129087	Tursiops truncatus	59.67	1.00e-110	391.00
IUUC-Vpa-130785	Vicugna pacos	60.27	1.00e-104	371.00
IUUC-Xtr-132801	Xenopus tropicalis	60.33	8.00e-104	369.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence