iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-048860

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AGTP01053765

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000005233.2	ENSSTOT00000005244.2	ENSSTOP00000004706.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.70e-135	450.3	567	899

Active Site

Position(s)	Description	Evidence
868	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 567  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 654
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lk gG+ni Vt+eNk+eY+ l++e
   Q: 655  GFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKVTSHDLKMGGSNILVTEENKDEYIGLMTE 740
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af +Gfnev+pl++l++F+e+ele+++cG++e+d+ d++++t y++ yt++s++i+wFw++++e ++e r ++LqFv
   Q: 741  WRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFV 828
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 829  TGTCRLPLGGFAELMgnngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 899
           *********************************************************************96 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

VSSAKLKRKK NWFGTATYTD VVVDGEIKKT AKSSSSSNPK WDEQLTVNVT PQSTLEFRVW 60
SHHTLKADAL LGRATIDLKQ ALLKHNRKLE KVKEQLKLSL ENKNGIVQTG ELIVVLDGLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTCTAGTG CCAAACTAAA AAGAAAAAAG AACTGGTTTG GAACAGCAAC ATATACAGAT 60
GTAGTTGTAG ATGGAGAAAT TAAAAAAACA GCCAAATCCA GTAGTTCTTC TAATCCAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	92.35	0.00e+00	1701.00
IUUC-Apl-003310	Anas platyrhynchos	82.38	0.00e+00	1504.00
IUUC-Aca-005388	Anolis carolinensis	80.00	0.00e+00	1412.00
IUUC-Ame-010992	Astyanax mexicanus	92.14	0.00e+00	838.00
IUUC-Bta-012857	Bos taurus	91.02	0.00e+00	1653.00
IUUC-Cel-018299	Caenorhabditis elegans	67.18	0.00e+00	840.00
IUUC-Cja-019448	Callithrix jacchus	93.35	0.00e+00	1731.00
IUUC-Cfa-020728	Canis familiaris	93.24	0.00e+00	1707.00
IUUC-Cpo-021635	Cavia porcellus	90.81	0.00e+00	1680.00
IUUC-Csa-023805	Chlorocebus sabaeus	93.89	0.00e+00	1321.00
IUUC-Cho-024943	Choloepus hoffmanni	81.74	0.00e+00	1187.00
IUUC-Cin-025212	Ciona intestinalis	73.70	0.00e+00	908.00
IUUC-Csv-026256	Ciona savignyi	72.66	0.00e+00	902.00
IUUC-Dre-028245	Danio rerio	72.04	0.00e+00	1234.00
IUUC-Dno-029618	Dasypus novemcinctus	93.35	0.00e+00	1708.00
IUUC-Dor-030665	Dipodomys ordii	78.99	0.00e+00	1149.00
IUUC-Dme-032041	Drosophila melanogaster	71.19	0.00e+00	901.00
IUUC-Ete-032779	Echinops telfairi	95.07	0.00e+00	1119.00
IUUC-Eca-033313	Equus caballus	90.91	0.00e+00	1628.00
IUUC-Eeu-035259	Erinaceus europaeus	83.81	0.00e+00	1503.00
IUUC-Fca-035420	Felis catus	91.91	0.00e+00	1693.00
IUUC-Fal-037335	Ficedula albicollis	82.49	0.00e+00	1493.00
IUUC-Gmo-039172	Gadus morhua	86.62	0.00e+00	1052.00
IUUC-Gga-040246	Gallus gallus	82.76	0.00e+00	1488.00
IUUC-Gac-042211	Gasterosteus aculeatus	91.94	0.00e+00	1161.00
IUUC-Ggo-045001	Gorilla gorilla	91.43	0.00e+00	1560.00
IUUC-Hsa-046544	Homo sapiens	92.57	0.00e+00	1717.00
IUUC-Lch-050398	Latimeria chalumnae	77.30	0.00e+00	1353.00
IUUC-Loc-052116	Lepisosteus oculatus	93.69	0.00e+00	1181.00
IUUC-Laf-053551	Loxodonta africana	90.81	0.00e+00	1638.00
IUUC-Meu-056455	Macropus eugenii	66.42	0.00e+00	810.00
IUUC-Mga-059986	Meleagris gallopavo	82.12	0.00e+00	1496.00
IUUC-Mmr-060945	Microcebus murinus	90.59	0.00e+00	1659.00
IUUC-Mdo-063024	Monodelphis domestica	82.23	0.00e+00	1444.00
IUUC-Mmu-063202	Mus musculus	90.89	0.00e+00	1623.00
IUUC-Mpu-065773	Mustela putorius furo	92.26	0.00e+00	1680.00
IUUC-Mlu-067373	Myotis lucifugus	96.46	0.00e+00	650.00
IUUC-Nle-069188	Nomascus leucogenys	93.02	0.00e+00	1723.00
IUUC-Opr-070965	Ochotona princeps	88.11	0.00e+00	1598.00
IUUC-Ont-072226	Oreochromis niloticus	92.29	0.00e+00	1167.00
IUUC-Oan-073497	Ornithorhynchus anatinus	84.94	0.00e+00	1506.00
IUUC-Ocu-073891	Oryctolagus cuniculus	89.46	0.00e+00	1589.00
IUUC-Ola-087438	Oryzias latipes	89.44	0.00e+00	1163.00
IUUC-Oga-087922	Otolemur garnettii	92.26	0.00e+00	1675.00
IUUC-Oar-089317	Ovis aries	90.14	0.00e+00	1623.00
IUUC-Ptr-090484	Pan troglodytes	92.68	0.00e+00	1717.00
IUUC-Pan-092117	Papio anubis	92.79	0.00e+00	1721.00
IUUC-Psi-093338	Pelodiscus sinensis	82.83	0.00e+00	1503.00
IUUC-Pma-094279	Petromyzon marinus	74.91	0.00e+00	847.00
IUUC-Pfo-096171	Poecilia formosa	92.64	0.00e+00	1170.00
IUUC-Pab-098654	Pongo abelii	90.98	0.00e+00	1278.00
IUUC-Pva-102811	Pteropus vampyrus	79.49	0.00e+00	1381.00
IUUC-Rno-106125	Rattus norvegicus	90.67	0.00e+00	1629.00
IUUC-Sha-107243	Sarcophilus harrisii	84.69	0.00e+00	1511.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	48.48	6.00e-150	524.00
IUUC-Sre-114929	Sporisorium reilianum	45.69	3.00e-151	529.00
IUUC-Ssc-115368	Sus scrofa	92.15	0.00e+00	1657.00
IUUC-Tgu-117079	Taeniopygia guttata	81.81	0.00e+00	1472.00
IUUC-Tru-118062	Takifugu rubripes	71.54	0.00e+00	1320.00
IUUC-Tsy-119507	Tarsius syrichta	87.47	0.00e+00	1587.00
IUUC-Tni-120151	Tetraodon nigroviridis	66.06	0.00e+00	1201.00
IUUC-Tre-122203	Trichoderma reesei	46.21	1.00e-148	520.00
IUUC-Tvi-122595	Trichoderma virens	46.14	1.00e-149	523.00
IUUC-Ttr-129260	Tursiops truncatus	82.04	0.00e+00	1441.00
IUUC-Uma-129332	Ustilago maydis	45.69	4.00e-145	508.00
IUUC-Vpa-130390	Vicugna pacos	79.73	0.00e+00	877.00
IUUC-Xtr-132877	Xenopus tropicalis	69.22	0.00e+00	1181.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence