iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065842

Ensembl Protein ID

ENSMPUP00000009974.1

UniProt Accession

M3YF67; M3YF67_MUSPF

Genbank Protein ID

ENSMPUP00000009974

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01095770

Gene Name

TRIM6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000010049.1	ENSMPUT00000010134.1	ENSMPUP00000009974.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	9.30e-06	25.7	9	77
E3 activity/RING/RING	4.50e-08	33.5	15	60

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk........tcPvtrqplteedlvPnltlrrl 64
           + +e  CpI lel ++P  + +G+++ +++I       ++         cPv++++ ++ dl Pn  l ++
   Q: 9    IRDEVTCPICLELLTEPLSIDCGHSFCQACIMGNS--TESvmgqdgesNCPVCQTSYQPGDLRPNRHLANI 77
           668999*************************6633..33344455555*****************998766 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl..qkwpglknssskefrCPlCr 46
           C+iCle + + pl+ +CgH f++ C+  +    +   + +e +CP+C+
   Q: 15   CPICLELLTE-PLSIDCGHSFCQACImgNST-ESVMGQDGESNCPVCQ 60
           ********99.***************87333.5557899999*****7 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MTSALLVDIR DEVTCPICLE LLTEPLSIDC GHSFCQACIM GNSTESVMGQ DGESNCPVCQ 60
TSYQPGDLRP NRHLANIADR LREVVLGPGM QLEGILCVHH GEKLQLFCKE DGKLICWLCE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTGGATATT CTTTATTCGG ACATTTTAAT CAGGCGTATT TTCAGTGTTC CTGAACACCG 60
ACACGAAATC GGAAAACCCA AGGGACGACC ACTTGCAAGC GCCGTCTGCG GCGCTCAGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0035458--P:cellular response to interferon-beta
GO:0098586--P:cellular response to virus
GO:0010994--P:free ubiquitin chain polymerization
GO:2000737--P:negative regulation of stem cell differentiation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045071--P:negative regulation of viral genome replication
GO:0002741--P:positive regulation of cytokine secretion involved in immune response
GO:0002230--P:positive regulation of defense response to virus by host
GO:0010628--P:positive regulation of gene expression
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0010800--P:positive regulation of peptidyl-threonine phosphorylation
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0060340--P:positive regulation of type I interferon-mediated signaling pathway
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0032496--P:response to lipopolysaccharide

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001965	Ailuropoda melanoleuca	92.18	0.00e+00	880.00
IUUC-Bta-013110	Bos taurus	54.20	1.00e-151	529.00
IUUC-Cja-019944	Callithrix jacchus	51.43	7.00e-130	457.00
IUUC-Cho-024416	Choloepus hoffmanni	58.37	7.00e-85	307.00
IUUC-Dno-029492	Dasypus novemcinctus	53.35	3.00e-144	505.00
IUUC-Dor-030480	Dipodomys ordii	77.33	2.00e-128	452.00
IUUC-Eeu-034968	Erinaceus europaeus	49.19	7.00e-105	374.00
IUUC-Fca-035533	Felis catus	92.18	0.00e+00	884.00
IUUC-Hsa-046006	Homo sapiens	81.52	0.00e+00	808.00
IUUC-Itr-048069	Ictidomys tridecemlineatus	78.21	0.00e+00	729.00
IUUC-Laf-053805	Loxodonta africana	77.57	0.00e+00	700.00
IUUC-Mmr-061023	Microcebus murinus	78.56	0.00e+00	739.00
IUUC-Mmu-063682	Mus musculus	78.03	0.00e+00	766.00
IUUC-Opr-071057	Ochotona princeps	49.48	1.00e-116	413.00
IUUC-Ocu-073956	Oryctolagus cuniculus	51.55	3.00e-130	459.00
IUUC-Oga-088267	Otolemur garnettii	81.72	0.00e+00	781.00
IUUC-Ptr-090573	Pan troglodytes	81.93	0.00e+00	813.00
IUUC-Pan-092745	Papio anubis	81.72	0.00e+00	796.00
IUUC-Rno-105401	Rattus norvegicus	79.88	0.00e+00	784.00
IUUC-Sar-113094	Sorex araneus	47.34	1.00e-102	367.00
IUUC-Ssc-115715	Sus scrofa	52.34	2.00e-139	489.00
IUUC-Tur-126362	Triticum urartu	37.88	2.00e-07	50.10

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence