iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054491

UUCD1 version

UUC-LoA-01080

Ensembl Protein ID

ENSLAFP00000007937.2

UniProt Accession

G3T3S5; G3T3S5_LOXAF

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000009464.2	ENSLAFT00000009464.2	ENSLAFP00000007937.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.20e-97	325.7	258	663

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.........kkkeklneenp...................................... 42
           tGl+NlgNtCYmNSvLQ+Ls++  +r+++l+                                                          
   Q: 258  TGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKldlnqwlavT---------Asdktrasykplpvtdtvfqineyqekdtgsicfrhpsl 337
           7******************************7665444432.........12335566678999999999999999999********** PP
   S: 43   ......................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk 109
                                 ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ ++f+gy+qqDaqEfl+ lld+++ el  
   Q: 338  ssglsggasmsrkmeliqpresSSQSISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPSFRGYAQQDAQEFLCELLDKIQHEL-- 424
           *******99999999999999889999************************************************************.. PP
   S: 110  eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......slqdcL 191
                  e+++++  +l   +++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +        ++++L
   Q: 425  -------ETTGTRLPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQCSGKdtasqpcLVTEML 506
           .......7788888999999************************************************877776667777777****** PP
   S: 192  esftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspe 269
           ++ft++e leg+  y c++c++k +           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++++
   Q: 507  AKFTETEALEGKI-YICDQCNSKHRkfsskpvvlteAQKQLMICHLPRVLRLHLKRFRWSGR-NNREKIGVHVGFEEILNMEPYCCRES 593
           **********965.*******888889999999999***********************998.7778********************99 PP
   S: 270  ekqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkrr 338
            k+ +  + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + ++++ev++   ++aY+lfY++r
   Q: 594  LKSLRpeSFIYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLNMCTMDEVCK---AQAYILFYTQR 663
           8887666899*************************9999********************...********985 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MDKCKHVGQL RLAQDHSILN PQKWHCVDCN TTESIWACLS CSHVACGRYI EEHALKHFQD 60
SSHPVALEVN EMYVFCYFCD DYVLNDNATG DLKLLRSTLS AIKSQNYHCT TRSGRILRSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAAGT GCAAACACGT TGGGCAATTG CGGCTTGCTC AAGATCATTC TATACTCAAC 60
CCTCAGAAAT GGCACTGTGT GGACTGCAAT ACAACTGAAT CCATCTGGGC TTGCCTTAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	89.40	0.00e+00	1248.00
IUUC-Apl-003673	Anas platyrhynchos	75.32	0.00e+00	1020.00
IUUC-Aca-004434	Anolis carolinensis	72.81	0.00e+00	1004.00
IUUC-Ame-010986	Astyanax mexicanus	64.34	0.00e+00	863.00
IUUC-Bta-012774	Bos taurus	87.95	0.00e+00	1216.00
IUUC-Cja-019619	Callithrix jacchus	87.54	0.00e+00	1192.00
IUUC-Cfa-020957	Canis familiaris	89.40	0.00e+00	1263.00
IUUC-Csa-023177	Chlorocebus sabaeus	88.41	0.00e+00	1206.00
IUUC-Cho-024877	Choloepus hoffmanni	87.13	0.00e+00	806.00
IUUC-Cin-025587	Ciona intestinalis	48.85	4.00e-108	386.00
IUUC-Csv-025814	Ciona savignyi	44.78	7.00e-155	540.00
IUUC-Dre-027878	Danio rerio	71.84	9.00e-175	607.00
IUUC-Dno-029832	Dasypus novemcinctus	89.83	0.00e+00	1261.00
IUUC-Ete-032627	Echinops telfairi	89.40	0.00e+00	1244.00
IUUC-Eca-033863	Equus caballus	86.21	0.00e+00	1175.00
IUUC-Eeu-035225	Erinaceus europaeus	84.01	0.00e+00	1140.00
IUUC-Fca-036288	Felis catus	89.11	0.00e+00	1248.00
IUUC-Fal-037207	Ficedula albicollis	74.21	0.00e+00	998.00
IUUC-Gga-040457	Gallus gallus	74.89	0.00e+00	992.00
IUUC-Gac-042595	Gasterosteus aculeatus	54.21	0.00e+00	706.00
IUUC-Ggo-044926	Gorilla gorilla	88.84	0.00e+00	1206.00
IUUC-Hsa-046079	Homo sapiens	88.41	0.00e+00	1206.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	88.86	0.00e+00	1222.00
IUUC-Lch-050260	Latimeria chalumnae	67.23	0.00e+00	912.00
IUUC-Loc-051981	Lepisosteus oculatus	76.90	0.00e+00	652.00
IUUC-Mcc-055694	Macaca mulatta	88.12	0.00e+00	1201.00
IUUC-Meu-055971	Macropus eugenii	48.09	2.00e-110	393.00
IUUC-Mga-059523	Meleagris gallopavo	74.75	0.00e+00	1009.00
IUUC-Mmr-060885	Microcebus murinus	90.43	0.00e+00	1250.00
IUUC-Mdo-063018	Monodelphis domestica	79.45	0.00e+00	1087.00
IUUC-Mmu-064012	Mus musculus	77.06	0.00e+00	1032.00
IUUC-Mpu-066207	Mustela putorius furo	88.39	0.00e+00	1257.00
IUUC-Mlu-066929	Myotis lucifugus	84.74	0.00e+00	1143.00
IUUC-Nle-069313	Nomascus leucogenys	78.22	0.00e+00	1025.00
IUUC-Opr-070375	Ochotona princeps	81.29	0.00e+00	1074.00
IUUC-Ont-071637	Oreochromis niloticus	67.33	2.00e-176	612.00
IUUC-Oan-073030	Ornithorhynchus anatinus	76.60	0.00e+00	824.00
IUUC-Ocu-074836	Oryctolagus cuniculus	85.80	0.00e+00	1176.00
IUUC-Ola-086413	Oryzias latipes	54.93	2.00e-161	562.00
IUUC-Oga-088367	Otolemur garnettii	89.57	0.00e+00	1218.00
IUUC-Oar-089953	Ovis aries	88.41	0.00e+00	1244.00
IUUC-Ptr-090980	Pan troglodytes	88.41	0.00e+00	1204.00
IUUC-Pan-092748	Papio anubis	88.68	0.00e+00	1212.00
IUUC-Psi-093353	Pelodiscus sinensis	63.98	0.00e+00	846.00
IUUC-Pfo-096413	Poecilia formosa	55.00	0.00e+00	721.00
IUUC-Pab-098514	Pongo abelii	88.70	0.00e+00	1206.00
IUUC-Pva-102984	Pteropus vampyrus	87.81	0.00e+00	1231.00
IUUC-Rno-106019	Rattus norvegicus	78.82	0.00e+00	1090.00
IUUC-Sha-106965	Sarcophilus harrisii	78.16	0.00e+00	1074.00
IUUC-Ssc-115299	Sus scrofa	88.65	0.00e+00	1256.00
IUUC-Tgu-117160	Taeniopygia guttata	75.07	0.00e+00	1016.00
IUUC-Tru-118156	Takifugu rubripes	61.86	0.00e+00	833.00
IUUC-Tni-119733	Tetraodon nigroviridis	62.30	0.00e+00	836.00
IUUC-Tbe-128084	Tupaia belangeri	82.61	0.00e+00	1162.00
IUUC-Ttr-128928	Tursiops truncatus	90.13	0.00e+00	1255.00
IUUC-Vpa-130706	Vicugna pacos	89.10	0.00e+00	1246.00
IUUC-Xtr-132061	Xenopus tropicalis	70.86	0.00e+00	924.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence