iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.70e-72	242.7	307	1124

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.........kkkeklneenp....................kepkgellkslqklfeelwkskkkav 68
           Gl+NlgNtC++N+v+QcL+++p l + l+e                   p                     ++ g l+ +l++ +eel +   +++
   Q: 307  GLTNLGNTCFFNAVMQCLAQTPFLLSVLKElsepgeefiL---------PggtftikdkgdielpmikgtLSSWGGLTAALANALEEL-QAGGSVF 392
           9*************************99996555444441.........14444544445555656666667777*************.88999** PP
   S: 69   sprellkalkkeaeefsgyeqqDaqEflaflldqle.eelkk......eknkpkeeeeeed.kselsdeaeekkkkknk.........slisdlFq 147
           +pr+l++ l+ + ++f+g +q+Da+E+l++ll++++ e+lk+      + n  ++++  ++ ++e+ ++ +                    +++F+
   Q: 393  TPRKLFDRLCVKCPQFTGGDQHDAHELLRQLLESVRnEDLKRyqrvilQ-NLGYKDQDVNSvSEEMRQKCK-------IygnqagdriLRPEQVFR 480
           **********************************972566555555431.222222211110112222222.......12233444456679**** PP
   S: 148  gqlksqikclecdnvssreepfldlslpvpgkeetkke.......................................................... 185
           g l s+++c++c+nvssr+e fld+slpv  ++ + ++                                                          
   Q: 481  GFLVSTLTCQDCHNVSSRHEYFLDMSLPVAVEKPQPPQrrkpspelsltsssssvtpstgqptintkftdgsvnftasspsfflhaheaaslgpsk 576
           ******************************888554449999999*************************************************** PP
   S: 186  ................................................................................................ 185
                                                                                                           
   Q: 577  sqvkkekerqrkakraakkrqksslnlngndsgngnelaesvdqddaslaslgagdgqandgleqtngqtedsttssvttsehsdadvednlvedt 672
           ************************************************************************************************ PP
   S: 186  ................................................................................................ 185
                                                                                                           
   Q: 673  aapstnnvpsstasltapsktymdsngnaqppgekrddtpehmdkdsleedendsgiatspaptatnsststsatgnnnsvagsglsgssgaledp 768
           ************************************************************************************************ PP
   S: 186  ..........................................................................................slqdcL 191
                                                                                                     s+q+cL
   Q: 769  lapaslvtaglsekgasvirqvsvgaeqgasngtedadgeakaieqpektpsqaqamaqaqartkrvrtqsysdwsttiapryqcedgecSVQSCL 864
           ************************************************************************************************ PP
   S: 192  esftkeeelegenkyycekckkkqe............aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke. 274
           ++ft+ e ++g+nk+ c++c+++ +            a+k+l +++ P vLilhLkRf+   + +  +k+++ v++p  Ld++ fc s+ ++  + 
   Q: 865  NNFTAVELMTGQNKVGCDSCTQRINgsdpkaksvntnATKQLLVSSPPAVLILHLKRFQLGPR-CIFRKLTRPVSYPNLLDIAAFCGSKVKNLPNi 959
           *********************8888889999999999*********************99886.8888********************55444445 PP
   S: 275  .....kkkYeLiavvvHsGslssGHYvayvkn................................................................ 301
                k  Y L++vv HsG++ +GHY+ayvk                                                                 
   Q: 960  drkqkKLLYALYGVVEHSGGMYGGHYTAYVKVrpkvapgdkrwkflphgskaeldqdddqlkkleellakekareqhlkvlddsddfsnsssnsst 1055
           5555599***************************************************************************************** PP
   S: 302  ....................................ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
                                                 gkW++++Ds+V+ev+e++ l+   ++aY+lfY+r
   Q: 1056 sdesqtpatpleeqqtqqaqqpqqpqqleeaanvraPPGKWYYVSDSRVQEVSEDTALK---AQAYLLFYER 1124
           ***********99999999999999888877777666788*******************...********98 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MVKKRQADSR DHDCSTDSGN EDLHHRKGLG SPGQSDGATP TTASCQHIKK AVDAARLRRL 60
LKSTGLLYEC SQCQKLGKTA GSAAGAGASE GAVGPGGNPV TFEFDNTLWL CLKCGSQLCG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGCAACGGT CACACTTGGT CACGTCGTTC ACGTTTTCTA TTTACGCATA AACGAATAAA 60
AAGCGCCTAA AAGTGCTATA AAACATATAT GTTGTGTGCT CATGTGCTAC ACATATCGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG4165

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	28.70	5.00e-15	76.30
IUUC-Aml-002331	Ailuropoda melanoleuca	51.28	1.00e-37	151.00
IUUC-Apl-003512	Anas platyrhynchos	51.30	8.00e-39	154.00
IUUC-Aca-004284	Anolis carolinensis	52.26	2.00e-37	150.00
IUUC-Aly-006422	Arabidopsis lyrata	29.00	1.00e-16	81.60
IUUC-Ath-007211	Arabidopsis thaliana	31.60	6.00e-19	89.00
IUUC-Ame-010735	Astyanax mexicanus	52.08	5.00e-36	144.00
IUUC-Bta-012880	Bos taurus	38.25	1.00e-33	137.00
IUUC-Bol-015853	Brassica oleracea	31.84	7.00e-19	88.60
IUUC-Bra-017226	Brassica rapa	32.34	7.00e-21	95.10
IUUC-Cja-019144	Callithrix jacchus	47.31	1.00e-36	147.00
IUUC-Cfa-020971	Canis familiaris	50.00	2.00e-37	150.00
IUUC-Cpo-022497	Cavia porcellus	50.98	4.00e-36	145.00
IUUC-Csa-023910	Chlorocebus sabaeus	47.31	4.00e-36	145.00
IUUC-Cho-024315	Choloepus hoffmanni	40.26	4.00e-21	95.90
IUUC-Cin-025775	Ciona intestinalis	38.00	2.00e-14	70.50
IUUC-Csv-026075	Ciona savignyi	45.77	4.00e-30	125.00
IUUC-Dre-028106	Danio rerio	50.96	3.00e-37	149.00
IUUC-Dno-029456	Dasypus novemcinctus	48.50	2.00e-38	152.00
IUUC-Dor-030438	Dipodomys ordii	40.72	2.00e-27	117.00
IUUC-Ete-032736	Echinops telfairi	34.91	2.00e-26	114.00
IUUC-Eca-034211	Equus caballus	50.32	4.00e-37	149.00
IUUC-Eeu-034835	Erinaceus europaeus	46.41	1.00e-30	127.00
IUUC-Fca-035947	Felis catus	50.31	1.00e-35	144.00
IUUC-Fal-037029	Ficedula albicollis	48.34	3.00e-31	129.00
IUUC-Gmo-039228	Gadus morhua	49.67	6.00e-35	141.00
IUUC-Gga-040823	Gallus gallus	51.95	4.00e-39	155.00
IUUC-Gac-042406	Gasterosteus aculeatus	50.67	4.00e-36	145.00
IUUC-Gma-044402	Glycine max	31.65	1.00e-18	88.20
IUUC-Ggo-045402	Gorilla gorilla	46.43	7.00e-36	144.00
IUUC-Hsa-046430	Homo sapiens	46.71	4.00e-36	145.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	48.50	6.00e-31	127.00
IUUC-Lch-049547	Latimeria chalumnae	49.68	2.00e-36	147.00
IUUC-Loc-051814	Lepisosteus oculatus	47.09	1.00e-35	144.00
IUUC-Laf-053988	Loxodonta africana	50.65	3.00e-38	152.00
IUUC-Mcc-055491	Macaca mulatta	47.31	3.00e-36	145.00
IUUC-Meu-056256	Macropus eugenii	50.97	2.00e-38	153.00
IUUC-Mtr-057945	Medicago truncatula	29.67	1.00e-16	81.30
IUUC-Mga-059833	Meleagris gallopavo	51.95	2.00e-39	156.00
IUUC-Mmr-060952	Microcebus murinus	47.62	3.00e-37	149.00
IUUC-Mdo-062642	Monodelphis domestica	50.32	3.00e-38	153.00
IUUC-Mmu-063945	Mus musculus	47.31	4.00e-37	149.00
IUUC-Mac-064941	Musa acuminata	31.58	8.00e-20	91.70
IUUC-Mpu-065944	Mustela putorius furo	44.00	1.00e-36	147.00
IUUC-Mlu-067049	Myotis lucifugus	41.50	1.00e-36	147.00
IUUC-Nle-069828	Nomascus leucogenys	47.31	3.00e-37	149.00
IUUC-Opr-070969	Ochotona princeps	38.65	1.00e-31	130.00
IUUC-Ont-071786	Oreochromis niloticus	51.97	1.00e-37	150.00
IUUC-Oan-073656	Ornithorhynchus anatinus	40.19	1.00e-36	147.00
IUUC-Ocu-074323	Oryctolagus cuniculus	48.50	1.00e-38	154.00
IUUC-Obr-076743	Oryza brachyantha	31.55	1.00e-16	82.00
IUUC-Ogl-077739	Oryza glaberrima	29.13	8.00e-15	75.10
IUUC-Ola-087238	Oryzias latipes	49.66	3.00e-35	142.00
IUUC-Oga-088379	Otolemur garnettii	47.31	5.00e-38	152.00
IUUC-Oar-089718	Ovis aries	37.90	2.00e-32	133.00
IUUC-Ptr-091358	Pan troglodytes	46.71	2.00e-36	147.00
IUUC-Pan-092023	Papio anubis	47.31	3.00e-36	145.00
IUUC-Psi-093256	Pelodiscus sinensis	47.74	8.00e-35	141.00
IUUC-Ppa-095825	Physcomitrella patens	31.44	1.00e-18	88.20
IUUC-Pfo-097202	Poecilia formosa	49.01	2.00e-35	143.00
IUUC-Pab-098539	Pongo abelii	46.71	2.00e-36	147.00
IUUC-Pop-099136	Populus trichocarpa	32.04	7.00e-17	82.00
IUUC-Pca-101069	Procavia capensis	46.10	1.00e-29	124.00
IUUC-Ppe-101794	Prunus persica	32.58	3.00e-19	89.70
IUUC-Pva-102985	Pteropus vampyrus	47.40	1.00e-35	144.00
IUUC-Rno-105538	Rattus norvegicus	46.71	1.00e-36	147.00
IUUC-Sha-107022	Sarcophilus harrisii	49.35	1.00e-37	150.00
IUUC-Sly-111491	Solanum lycopersicum	31.25	2.00e-19	90.90
IUUC-Sar-113530	Sorex araneus	38.39	1.00e-31	130.00
IUUC-Ssc-115870	Sus scrofa	50.00	8.00e-37	148.00
IUUC-Tgu-116907	Taeniopygia guttata	51.30	1.00e-38	154.00
IUUC-Tru-117835	Takifugu rubripes	51.41	2.00e-34	140.00
IUUC-Tsy-118869	Tarsius syrichta	47.31	7.00e-38	151.00
IUUC-Tni-119716	Tetraodon nigroviridis	50.34	3.00e-35	142.00
IUUC-Tca-121701	Theobroma cacao	33.18	4.00e-21	96.30
IUUC-Tur-126788	Triticum urartu	27.45	2.00e-12	67.80
IUUC-Tbe-128041	Tupaia belangeri	37.85	2.00e-34	140.00
IUUC-Ttr-128901	Tursiops truncatus	50.00	9.00e-37	147.00
IUUC-Vpa-130331	Vicugna pacos	48.21	9.00e-37	147.00
IUUC-Xtr-131794	Xenopus tropicalis	51.63	2.00e-36	146.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence