iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046922

Ensembl Protein ID

ENSP00000260130.4

UniProt Accession

O00560; B2R5Q7; B4DUH3; B7ZLN2; O00173; O43391; Q14CP2; SDCB1_HUMAN

Genbank Protein ID

AAC52050.1; AAB97144.1; AAB51246.1; BAG62335.1; BAG35204.1; EAW86814.1; AAI13675.1; AAI13677.1; AAI43916.1; AAI43917.1

Protein Name

Syntenin-1; Melanoma differentiation-associated protein 9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; Scaffold protein Pbp1; Syndecan-binding protein 1

Genbank Nucleotide ID

AF006636; AF000652; U83463; AK300647; AK312274; AC068522; BC113674; BC113676; BC143915; BC143916

Gene Name

SDCBP; MDA9; SYCL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000137575.11	ENST00000260130.8	ENSP00000260130.4
ENSG00000137575.11	ENST00000424270.6	ENSP00000395351.2
ENSG00000137575.11	ENST00000523483.5	ENSP00000428184.1
ENSG00000137575.11	ENST00000520168.5	ENSP00000430730.1
ENSG00000137575.11	ENST00000447267.4	ENSP00000397820.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Other/Other	UBD/Other/Other	21949238

Organism

Homo sapiens

Functional Description
(View)

Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).

Protein Sequence
(Fasta)

MSLYPSLEDL KVDKVIQAQT AFSANPANPA ILSEASAPIP HDGNLYPRLY PELSQYMGLS 60
LNEEEIRANV AVVSGAPLQG QLVARPSSIN YMVAPVTGND VGIRRAEIKQ GIREVILCKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAGCTGCG ATGCACACAG TAGTGAGTGG GTGGCACGGG GCCCGCGGGC ACGAACAGCC 60
GAAGAGCGGA GAAGACTGGG AGCATAACCG CTGGGCAGCG GGCAGCGGAC AGCGGGCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted

Interpro

IPR001478--PDZ
IPR030528--SDCBP

PROSITE

PS50106--PDZ

Pfam

PF00595--PDZ

SMART

SM00228--PDZ

Gene Ontology

GO:0005912--C:adherens junction
GO:0035578--C:azurophil granule lumen
GO:0072562--C:blood microparticle
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0070062--C:extracellular exosome
GO:0005576--C:extracellular region
GO:0005615--C:extracellular space
GO:1903561--C:extracellular vesicle
GO:0005925--C:focal adhesion
GO:0005895--C:interleukin-5 receptor complex
GO:0043231--C:intracellular membrane-bounded organelle
GO:0042470--C:melanosome
GO:0016020--C:membrane
GO:0045121--C:membrane raft
GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0045296--F:cadherin binding
GO:0008093--F:cytoskeletal adaptor activity
GO:0005109--F:frizzled binding
GO:0042802--F:identical protein binding
GO:0005137--F:interleukin-5 receptor binding
GO:0005546--F:phosphatidylinositol-4,5-bisphosphate binding
GO:0046982--F:protein heterodimerization activity
GO:0047485--F:protein N-terminus binding
GO:0045545--F:syndecan binding
GO:0030036--P:actin cytoskeleton organization
GO:0007268--P:chemical synaptic transmission
GO:0048013--P:ephrin receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0032435--P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0002091--P:negative regulation of receptor internalization
GO:0043312--P:neutrophil degranulation
GO:0030307--P:positive regulation of cell growth
GO:0030335--P:positive regulation of cell migration
GO:0008284--P:positive regulation of cell proliferation
GO:0010718--P:positive regulation of epithelial to mesenchymal transition
GO:1903543--P:positive regulation of exosomal secretion
GO:1903553--P:positive regulation of extracellular exosome assembly
GO:0046330--P:positive regulation of JNK cascade
GO:0010862--P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0042327--P:positive regulation of phosphorylation
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:0006612--P:protein targeting to membrane
GO:0007346--P:regulation of mitotic cell cycle
GO:0006930--P:substrate-dependent cell migration, cell extension

KEGG

hsa:6386

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001828	Ailuropoda melanoleuca	94.63	6.00e-169	586.00
IUUC-Apl-003873	Anas platyrhynchos	87.92	5.00e-156	543.00
IUUC-Bta-012904	Bos taurus	92.95	6.00e-168	583.00
IUUC-Bdi-014056	Brachypodium distachyon	28.57	2.20e-02	33.90
IUUC-Cja-019757	Callithrix jacchus	97.65	3.00e-174	603.00
IUUC-Cpo-022386	Cavia porcellus	93.96	1.00e-166	578.00
IUUC-Csa-024043	Chlorocebus sabaeus	94.97	3.00e-166	577.00
IUUC-Dor-030235	Dipodomys ordii	94.66	8.00e-159	552.00
IUUC-Ete-033137	Echinops telfairi	91.28	9.00e-166	575.00
IUUC-Eca-033739	Equus caballus	94.65	8.00e-170	589.00
IUUC-Eeu-034833	Erinaceus europaeus	77.85	4.00e-131	460.00
IUUC-Fca-036103	Felis catus	94.97	3.00e-170	590.00
IUUC-Fal-037584	Ficedula albicollis	87.25	7.00e-156	542.00
IUUC-Gga-040373	Gallus gallus	87.58	1.00e-154	538.00
IUUC-Gac-041533	Gasterosteus aculeatus	64.17	3.00e-113	401.00
IUUC-Ggo-044813	Gorilla gorilla	99.66	1.00e-176	611.00
IUUC-Itr-048546	Ictidomys tridecemlineatus	95.64	3.00e-169	587.00
IUUC-Mga-059793	Meleagris gallopavo	84.69	1.00e-151	528.00
IUUC-Mmr-061366	Microcebus murinus	95.30	3.00e-171	593.00
IUUC-Mmu-064353	Mus musculus	90.30	7.00e-161	559.00
IUUC-Mpu-066678	Mustela putorius furo	95.97	1.00e-171	595.00
IUUC-Mlu-067393	Myotis lucifugus	95.64	2.00e-170	590.00
IUUC-Nle-069522	Nomascus leucogenys	99.33	2.00e-176	611.00
IUUC-Opr-070549	Ochotona princeps	79.19	8.00e-134	469.00
IUUC-Oan-072873	Ornithorhynchus anatinus	78.22	1.00e-134	472.00
IUUC-Ocu-073976	Oryctolagus cuniculus	95.97	1.00e-170	592.00
IUUC-Ola-087243	Oryzias latipes	66.12	1.00e-114	405.00
IUUC-Oga-088683	Otolemur garnettii	94.30	2.00e-168	584.00
IUUC-Pan-091787	Papio anubis	97.99	4.00e-173	600.00
IUUC-Psi-093783	Pelodiscus sinensis	87.25	1.00e-157	548.00
IUUC-Pca-100815	Procavia capensis	93.29	4.00e-165	573.00
IUUC-Pva-102191	Pteropus vampyrus	85.91	7.00e-148	516.00
IUUC-Rno-106107	Rattus norvegicus	89.33	7.00e-158	549.00
IUUC-Sha-107239	Sarcophilus harrisii	90.94	6.00e-164	569.00
IUUC-Sar-113431	Sorex araneus	95.64	3.00e-171	594.00
IUUC-Tgu-117393	Taeniopygia guttata	87.25	3.00e-156	544.00
IUUC-Tru-118034	Takifugu rubripes	28.87	2.00e-09	58.50
IUUC-Tsy-119079	Tarsius syrichta	95.30	3.00e-170	590.00
IUUC-Tbe-127482	Tupaia belangeri	85.91	3.00e-147	514.00
IUUC-Ttr-128987	Tursiops truncatus	76.51	3.00e-130	457.00
IUUC-Vpa-130478	Vicugna pacos	68.12	6.00e-111	393.00
IUUC-Xtr-132378	Xenopus tropicalis	78.19	2.00e-140	491.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence