iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cin-025417

UUCD1 version

UUC-CiI-00047

Ensembl Protein ID

ENSCINP00000035749.1

UniProt Accession

H2Y1G5; H2Y1G5_CIOIN

Protein Name

Uncharacterized protein

Gene Name

LOC100186473

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCING00000023687.1	ENSCINT00000031623.1	ENSCINP00000035749.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.90e-104	348.9	492	815

Active Site

Position(s)	Description	Evidence
787	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           +s+lk+++ v+f++Eeg++  Gv+re+++ ls+e+ np++glf +s  d +++qpn+ s + np+hl++Fef+G++l +al++++l++ 
   Q: 492  QSNLKHKFSVQFSNEEGIGD-GVFREWFSVLSNEILNPEYGLFIQS-FDGCSFQPNSRSSI-NPDHLSYFEFAGKILSVALYHKQLING 577
           7899****************.**********************655.588999******99.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            l++sfyk+llg+k+++ d++++dpe++ +l++i++n   di+e+gl+l+f v+++++g ++e eL pgG+++ Vt+eNk+eYv+lv+e
   Q: 578  SLTSSFYKHLLGRKVDYRDVASIDPEYATNLQWILDN---DITEIGLELSFVVETDVFGRMEEIELTPGGSKVAVTEENKQEYVQLVTE 663
           ***********************************99...************************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++ i+ q++af +Gfne+ip  l+++Fte e++l+  G++++dv  +k+ t+y g y++ +++i wFwe++ +++ e+r+ +L+F+
   Q: 664  LRMTRAIQPQLDAFIRGFNEIIPSYLIRIFTEDEMDLMFTGCKDVDVGYWKSITEYSGCYNQHHQVILWFWECVGKMDTEDRSSLLHFA 752
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.k 331
           Tg+srlP   ++  +   fvi + +++++ lPs++TC+++L+LPeY+s+++l+ kLl+Ai+ +  
   Q: 753  TGRSRLPSPSVKLSN-T-FVICNmSSQKNLLPSASTCMSMLRLPEYDSYDVLETKLLTAIRCGsH 815
           *******76665444.5.5555538888********************************98755 PP

Organism

Ciona intestinalis

Protein Sequence
(Fasta)

MWSPRQQLMR LTRSLRSGRS LELPADPAAA VRILMPMVFA NQHKSLMELL DNSSFDVNHA 60
IGRSRRTLLH IAANCGQLEC VTGLLKVGGD PNAQDIAGCC AIHLAAKNGN KKCVEKLLEA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGGAGTC CTAGACAGCA ATTGATGCGG TTAACCCGTT CGTTGCGAAG TGGAAGAAGT 60
TTAGAGCTTC CTGCAGATCC AGCAGCAGCT GTAAGGATCC TGATGCCAAT GGTGTTCGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF00023--Ank
PF12796--Ank_2
PF00632--HECT

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001490	Ailuropoda melanoleuca	43.64	0.00e+00	734.00
IUUC-Apl-003400	Anas platyrhynchos	51.50	2.00e-140	491.00
IUUC-Aca-005375	Anolis carolinensis	50.00	1.00e-139	489.00
IUUC-Ame-011847	Astyanax mexicanus	51.40	8.00e-142	496.00
IUUC-Bta-012831	Bos taurus	43.42	0.00e+00	722.00
IUUC-Cja-019160	Callithrix jacchus	43.63	0.00e+00	736.00
IUUC-Cfa-020346	Canis familiaris	43.78	0.00e+00	743.00
IUUC-Cpo-021766	Cavia porcellus	43.67	0.00e+00	736.00
IUUC-Csa-023768	Chlorocebus sabaeus	43.67	0.00e+00	741.00
IUUC-Cho-024688	Choloepus hoffmanni	49.16	6.00e-132	463.00
IUUC-Csv-025993	Ciona savignyi	75.88	0.00e+00	731.00
IUUC-Dre-027819	Danio rerio	44.69	0.00e+00	746.00
IUUC-Dno-029027	Dasypus novemcinctus	43.34	0.00e+00	730.00
IUUC-Dor-030327	Dipodomys ordii	40.34	1.00e-176	612.00
IUUC-Ete-032966	Echinops telfairi	51.07	2.00e-139	488.00
IUUC-Eca-034339	Equus caballus	43.89	0.00e+00	748.00
IUUC-Eeu-034544	Erinaceus europaeus	46.84	1.00e-76	280.00
IUUC-Fca-035617	Felis catus	50.63	5.00e-139	486.00
IUUC-Fal-036687	Ficedula albicollis	51.50	3.00e-141	494.00
IUUC-Gmo-039508	Gadus morhua	52.52	1.00e-134	472.00
IUUC-Gga-040845	Gallus gallus	51.50	4.00e-141	494.00
IUUC-Gac-041894	Gasterosteus aculeatus	43.25	0.00e+00	705.00
IUUC-Ggo-044465	Gorilla gorilla	42.21	0.00e+00	698.00
IUUC-Hsa-045731	Homo sapiens	43.67	0.00e+00	741.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	43.93	0.00e+00	746.00
IUUC-Lch-050436	Latimeria chalumnae	51.18	5.00e-141	494.00
IUUC-Loc-052287	Lepisosteus oculatus	50.97	8.00e-141	493.00
IUUC-Laf-053846	Loxodonta africana	43.85	0.00e+00	741.00
IUUC-Mcc-055845	Macaca mulatta	43.67	0.00e+00	741.00
IUUC-Meu-056060	Macropus eugenii	39.22	2.00e-63	236.00
IUUC-Mga-059935	Meleagris gallopavo	51.50	4.00e-141	494.00
IUUC-Mmr-060960	Microcebus murinus	43.78	0.00e+00	744.00
IUUC-Mdo-061851	Monodelphis domestica	50.21	1.00e-139	489.00
IUUC-Mmu-063657	Mus musculus	43.89	0.00e+00	744.00
IUUC-Mpu-066161	Mustela putorius furo	53.40	3.00e-123	433.00
IUUC-Mlu-067354	Myotis lucifugus	42.97	0.00e+00	700.00
IUUC-Nle-069112	Nomascus leucogenys	43.67	0.00e+00	741.00
IUUC-Opr-070686	Ochotona princeps	46.00	1.00e-111	395.00
IUUC-Ont-072398	Oreochromis niloticus	43.69	0.00e+00	716.00
IUUC-Oan-073194	Ornithorhynchus anatinus	42.97	0.00e+00	705.00
IUUC-Ocu-074397	Oryctolagus cuniculus	51.82	5.00e-122	430.00
IUUC-Ola-086777	Oryzias latipes	49.59	1.00e-140	492.00
IUUC-Oga-088684	Otolemur garnettii	43.85	0.00e+00	743.00
IUUC-Oar-089428	Ovis aries	43.56	0.00e+00	724.00
IUUC-Ptr-090529	Pan troglodytes	43.56	0.00e+00	739.00
IUUC-Pan-091702	Papio anubis	43.67	0.00e+00	741.00
IUUC-Psi-093969	Pelodiscus sinensis	51.07	3.00e-140	491.00
IUUC-Pfo-097364	Poecilia formosa	43.81	0.00e+00	722.00
IUUC-Pab-098574	Pongo abelii	43.67	0.00e+00	741.00
IUUC-Pca-100525	Procavia capensis	45.15	8.00e-77	280.00
IUUC-Pva-102365	Pteropus vampyrus	53.59	5.00e-122	430.00
IUUC-Rno-105153	Rattus norvegicus	44.11	0.00e+00	745.00
IUUC-Sha-107319	Sarcophilus harrisii	50.86	3.00e-139	488.00
IUUC-Ssc-115865	Sus scrofa	43.67	0.00e+00	741.00
IUUC-Tgu-117225	Taeniopygia guttata	51.29	4.00e-141	494.00
IUUC-Tru-118026	Takifugu rubripes	49.68	2.00e-136	478.00
IUUC-Tsy-119407	Tarsius syrichta	53.89	4.00e-121	427.00
IUUC-Tni-120234	Tetraodon nigroviridis	41.49	1.00e-158	552.00
IUUC-Ttr-128667	Tursiops truncatus	43.56	0.00e+00	741.00
IUUC-Vpa-130200	Vicugna pacos	43.18	0.00e+00	709.00
IUUC-Xtr-132176	Xenopus tropicalis	52.15	1.00e-142	499.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence