iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052287

Ensembl Protein ID

ENSLOCP00000020427.1

UniProt Accession

W5NIG8; W5NIG8_LEPOC

Genbank Protein ID

ENSLOCP00000020427

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHAT01009151

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000016540.1	ENSLOCT00000020462.1	ENSLOCP00000020427.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.00e-119	396.9	615	945

Active Site

Position(s)	Description	Evidence
916	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           +++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s + np+hl++F+f+G++lg+al++++l+++
   Q: 615  NEKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIINPDYALFTQSA-DGTTFQPNSNSSV-NPDHLNYFRFAGQILGLALYHRQLVNI 700
           678999**************.**********************6666.67788*******9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG +i Vt++Nk eYv+lv+e
   Q: 701  YFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGVSILVTQDNKAEYVQLVTE 786
           ***********************************99...************************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++ i+ q++af +Gf++ ip++l++lF+e elell++G++eidv+d+kk+t+y++gy  ++p+i+wFwev+e++++eer  +LqFv
   Q: 787  LRMTRAIQPQINAFLQGFHTFIPPSLIQLFDEYELELLLSGMPEIDVNDWKKNTEYTSGYDLEEPVIKWFWEVVESLTQEERVLLLQFV 875
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           Tgssr+P+gGfa+l+     ++f+i     + + lP+s+TC+n+LkLPeY+++eil+++Ll+A + +  g
   Q: 876  TGSSRVPHGGFAYLMggsgLQKFTIAAvPYTSNLLPTSSTCINMLKLPEYPKQEILRDRLLVALHCGsYG 945
           *******************88899998677779*******************************986555 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MERAMEQLNV QLNRLTRSLR RARTVELPED NETAVYTLMP MVMADQHRSV AELLLNSKFD 60
VNYAFGRVKR SLLHIAANCG SVECLILLLK KGANPNYQDI SGCTPLHLAA RNGQKKCMGK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACAGGAAG AAAGGAAAAC AAATAGAAGG AAATAATGTG CAATGAATCA CAGATGGGTG 60
TCTCTGCAAT TTGAATAGTT CTGGTTGTTT TTTTGTAATT TAGAATGATT GAATATGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF12796--Ank_2
PF00632--HECT

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001490	Ailuropoda melanoleuca	84.62	0.00e+00	1650.00
IUUC-Apl-003400	Anas platyrhynchos	85.96	0.00e+00	1133.00
IUUC-Aca-005375	Anolis carolinensis	84.01	0.00e+00	1652.00
IUUC-Ame-011847	Astyanax mexicanus	88.67	0.00e+00	1755.00
IUUC-Bta-012831	Bos taurus	85.14	0.00e+00	1620.00
IUUC-Cja-019160	Callithrix jacchus	85.50	0.00e+00	1668.00
IUUC-Cfa-020346	Canis familiaris	84.75	0.00e+00	1657.00
IUUC-Cpo-021766	Cavia porcellus	84.65	0.00e+00	1656.00
IUUC-Csa-023768	Chlorocebus sabaeus	85.38	0.00e+00	1669.00
IUUC-Cho-024688	Choloepus hoffmanni	78.17	0.00e+00	1011.00
IUUC-Cin-025417	Ciona intestinalis	50.97	2.00e-140	492.00
IUUC-Csv-025993	Ciona savignyi	46.40	5.00e-145	508.00
IUUC-Dre-027819	Danio rerio	86.86	0.00e+00	1720.00
IUUC-Dno-029027	Dasypus novemcinctus	84.57	0.00e+00	1647.00
IUUC-Dor-030327	Dipodomys ordii	78.22	0.00e+00	1451.00
IUUC-Ete-032966	Echinops telfairi	79.45	0.00e+00	1535.00
IUUC-Eca-034339	Equus caballus	84.87	0.00e+00	1660.00
IUUC-Eeu-034544	Erinaceus europaeus	76.34	2.00e-138	486.00
IUUC-Fca-035617	Felis catus	81.69	0.00e+00	1144.00
IUUC-Fal-036687	Ficedula albicollis	87.74	0.00e+00	1726.00
IUUC-Gmo-039508	Gadus morhua	92.03	0.00e+00	872.00
IUUC-Gga-040845	Gallus gallus	87.87	0.00e+00	1735.00
IUUC-Gac-041894	Gasterosteus aculeatus	86.99	0.00e+00	1667.00
IUUC-Ggo-044465	Gorilla gorilla	82.08	0.00e+00	1593.00
IUUC-Hsa-045731	Homo sapiens	85.49	0.00e+00	1671.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	85.25	0.00e+00	1669.00
IUUC-Lch-050436	Latimeria chalumnae	86.67	0.00e+00	1698.00
IUUC-Laf-053846	Loxodonta africana	85.40	0.00e+00	1670.00
IUUC-Mcc-055845	Macaca mulatta	85.49	0.00e+00	1671.00
IUUC-Meu-056060	Macropus eugenii	82.86	0.00e+00	649.00
IUUC-Mga-059935	Meleagris gallopavo	85.01	0.00e+00	1656.00
IUUC-Mmr-060960	Microcebus murinus	85.20	0.00e+00	1666.00
IUUC-Mdo-061851	Monodelphis domestica	86.43	0.00e+00	1711.00
IUUC-Mmu-063657	Mus musculus	85.07	0.00e+00	1669.00
IUUC-Mpu-066161	Mustela putorius furo	92.71	0.00e+00	780.00
IUUC-Mlu-067354	Myotis lucifugus	83.48	0.00e+00	1581.00
IUUC-Nle-069112	Nomascus leucogenys	85.49	0.00e+00	1672.00
IUUC-Opr-070686	Ochotona princeps	83.37	0.00e+00	763.00
IUUC-Ont-072398	Oreochromis niloticus	86.11	0.00e+00	1671.00
IUUC-Oan-073194	Ornithorhynchus anatinus	84.99	0.00e+00	1603.00
IUUC-Ocu-074397	Oryctolagus cuniculus	77.15	0.00e+00	1461.00
IUUC-Ola-086777	Oryzias latipes	85.37	0.00e+00	1656.00
IUUC-Oga-088684	Otolemur garnettii	84.99	0.00e+00	1664.00
IUUC-Oar-089428	Ovis aries	84.36	0.00e+00	1626.00
IUUC-Ptr-090529	Pan troglodytes	85.38	0.00e+00	1669.00
IUUC-Pan-091702	Papio anubis	85.38	0.00e+00	1670.00
IUUC-Psi-093969	Pelodiscus sinensis	87.65	0.00e+00	1667.00
IUUC-Pfo-097364	Poecilia formosa	87.17	0.00e+00	1684.00
IUUC-Pab-098574	Pongo abelii	85.49	0.00e+00	1671.00
IUUC-Pca-100525	Procavia capensis	80.39	1.00e-167	583.00
IUUC-Pva-102365	Pteropus vampyrus	74.76	0.00e+00	1404.00
IUUC-Rno-105153	Rattus norvegicus	84.86	0.00e+00	1666.00
IUUC-Sha-107319	Sarcophilus harrisii	87.04	0.00e+00	1714.00
IUUC-Stu-112894	Solanum tuberosum	34.76	2.00e-55	211.00
IUUC-Sar-113449	Sorex araneus	63.28	9.00e-140	491.00
IUUC-Ssc-115865	Sus scrofa	84.78	0.00e+00	1657.00
IUUC-Tgu-117225	Taeniopygia guttata	87.82	0.00e+00	1734.00
IUUC-Tru-118026	Takifugu rubripes	86.60	0.00e+00	1669.00
IUUC-Tsy-119407	Tarsius syrichta	73.45	0.00e+00	1373.00
IUUC-Tni-120234	Tetraodon nigroviridis	84.95	0.00e+00	1330.00
IUUC-Tbe-127708	Tupaia belangeri	70.70	0.00e+00	733.00
IUUC-Ttr-128667	Tursiops truncatus	84.68	0.00e+00	1659.00
IUUC-Vpa-130200	Vicugna pacos	84.72	0.00e+00	1605.00
IUUC-Xtr-132176	Xenopus tropicalis	86.37	0.00e+00	1716.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence