iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000003494.4	ENSCAFT00000048268.2	ENSCAFP00000040534.1
ENSCAFG00000003494.4	ENSCAFT00000005626.4	ENSCAFP00000005210.3
ENSCAFG00000003494.4	ENSCAFT00000047249.2	ENSCAFP00000036475.1
ENSCAFG00000003494.4	ENSCAFT00000046058.1	ENSCAFP00000037598.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.60e-122	408.7	1258	1590

Active Site

Position(s)	Description	Evidence
1558	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1258 ELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1343
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n++Vt++Nk+eY+++
   Q: 1344 AFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIER 1426
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1427 MVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLR 1513
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1514 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1590
           ************************999***********************************************985 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

PLIVCLPPQN LYQNRFLGLA AMASPSRNSQ NRRRCKEPLR HSYNPGQFHS MAIRNGPHGT 60
VTIPRSTSDT DLVTSDSRST LMVSSSYYSI GHSQDLVIHW DIKEEVDAGD WIGMYLIGNI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGGGCACAG CGCGCCCCGG CTGCACCGAG CTGACAGCCC ATCGCATGTG GGGGTTTTCC 60
TAGTTGCTGA GGATTTCATT TGACGTTGCT GTAGTTTTGC GCTTACTTCT CTTGGGATCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	91.50	0.00e+00	1800.00
IUUC-Apl-003299	Anas platyrhynchos	82.98	0.00e+00	1739.00
IUUC-Aca-005024	Anolis carolinensis	84.18	0.00e+00	1699.00
IUUC-Bta-012604	Bos taurus	85.45	0.00e+00	2491.00
IUUC-Cja-019880	Callithrix jacchus	80.93	0.00e+00	2069.00
IUUC-Cpo-021466	Cavia porcellus	96.76	0.00e+00	1720.00
IUUC-Csa-023080	Chlorocebus sabaeus	86.31	0.00e+00	2493.00
IUUC-Cho-024740	Choloepus hoffmanni	92.74	0.00e+00	1138.00
IUUC-Dre-028750	Danio rerio	73.47	0.00e+00	1546.00
IUUC-Dno-030019	Dasypus novemcinctus	85.56	0.00e+00	2474.00
IUUC-Dor-031030	Dipodomys ordii	82.37	0.00e+00	919.00
IUUC-Ete-032352	Echinops telfairi	94.14	0.00e+00	1264.00
IUUC-Eca-033948	Equus caballus	89.59	0.00e+00	1816.00
IUUC-Eeu-034474	Erinaceus europaeus	70.35	0.00e+00	832.00
IUUC-Fca-036148	Felis catus	93.41	0.00e+00	1853.00
IUUC-Fal-036957	Ficedula albicollis	85.27	0.00e+00	1751.00
IUUC-Gmo-038714	Gadus morhua	69.00	0.00e+00	1019.00
IUUC-Gga-041194	Gallus gallus	83.83	0.00e+00	1749.00
IUUC-Gac-041366	Gasterosteus aculeatus	78.05	0.00e+00	1369.00
IUUC-Ggo-045442	Gorilla gorilla	78.70	0.00e+00	1588.00
IUUC-Hsa-045730	Homo sapiens	86.32	0.00e+00	2488.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	91.24	0.00e+00	1854.00
IUUC-Lch-050185	Latimeria chalumnae	72.48	0.00e+00	1382.00
IUUC-Loc-052744	Lepisosteus oculatus	79.63	0.00e+00	1563.00
IUUC-Laf-054368	Loxodonta africana	98.32	0.00e+00	1507.00
IUUC-Mcc-055487	Macaca mulatta	86.57	0.00e+00	2496.00
IUUC-Meu-056751	Macropus eugenii	91.60	0.00e+00	731.00
IUUC-Mga-059545	Meleagris gallopavo	84.71	0.00e+00	1749.00
IUUC-Mmr-061078	Microcebus murinus	88.01	0.00e+00	1762.00
IUUC-Mdo-062176	Monodelphis domestica	83.81	0.00e+00	1675.00
IUUC-Mmu-063513	Mus musculus	80.84	0.00e+00	2365.00
IUUC-Mpu-065786	Mustela putorius furo	88.26	0.00e+00	2565.00
IUUC-Mlu-067780	Myotis lucifugus	81.04	0.00e+00	2266.00
IUUC-Nle-069213	Nomascus leucogenys	92.07	0.00e+00	1844.00
IUUC-Opr-070208	Ochotona princeps	97.18	0.00e+00	1496.00
IUUC-Ont-072132	Oreochromis niloticus	83.00	0.00e+00	1363.00
IUUC-Oan-072807	Ornithorhynchus anatinus	86.33	0.00e+00	1752.00
IUUC-Ocu-074745	Oryctolagus cuniculus	85.05	0.00e+00	2445.00
IUUC-Ola-086981	Oryzias latipes	73.88	0.00e+00	1487.00
IUUC-Oga-087965	Otolemur garnettii	91.33	0.00e+00	1784.00
IUUC-Oar-089749	Ovis aries	90.15	0.00e+00	1795.00
IUUC-Ptr-091243	Pan troglodytes	86.26	0.00e+00	2485.00
IUUC-Pan-092201	Papio anubis	86.49	0.00e+00	2512.00
IUUC-Psi-093511	Pelodiscus sinensis	81.38	0.00e+00	1702.00
IUUC-Pfo-097001	Poecilia formosa	70.86	0.00e+00	1440.00
IUUC-Pab-098728	Pongo abelii	84.05	0.00e+00	2369.00
IUUC-Pca-100129	Procavia capensis	81.95	0.00e+00	1258.00
IUUC-Pva-102250	Pteropus vampyrus	85.52	0.00e+00	1707.00
IUUC-Rno-105031	Rattus norvegicus	82.27	0.00e+00	2405.00
IUUC-Tgu-117515	Taeniopygia guttata	85.46	0.00e+00	1748.00
IUUC-Tru-117914	Takifugu rubripes	75.44	0.00e+00	1374.00
IUUC-Tsy-119379	Tarsius syrichta	79.36	0.00e+00	792.00
IUUC-Tni-120178	Tetraodon nigroviridis	70.56	0.00e+00	1426.00
IUUC-Tbe-127762	Tupaia belangeri	81.77	0.00e+00	1668.00
IUUC-Ttr-128806	Tursiops truncatus	92.49	0.00e+00	1727.00
IUUC-Xtr-132903	Xenopus tropicalis	80.24	0.00e+00	1684.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence