iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000121067.17	ENST00000393328.6	ENSP00000377001.2
ENSG00000121067.17	ENST00000509869.5	ENSP00000423284.1
ENSG00000121067.17	ENST00000506399.5	ENSP00000425604.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	19164706; 15897469; 20463034; 18414007

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	2.00e-32	113.0	200	266
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	5.70e-09	35.2	299	329

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +D++l+v+g+ef+ahk++Laa+S+vF+a+f++e+eesk k++vei+dv+pevf+++++F+Ytgk+++ 
   Q: 200  TDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESK-KNRVEINDVEPEVFKEMMCFIYTGKAPNL 266
           7*************************************.*************************9986 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           +eN+++il +Adl+++++Lk +a+dfi++h 
   Q: 299  VENAAEILILADLHSADQLKTQAVDFINYHA 329
           79***************************95 PP

Organism

Homo sapiens

Functional Description
(View)

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL.

Protein Sequence
(Fasta)

MSRVPSPPPP AEMSSGPVAE SWCYTQIKVV KFSYMWTINN FSFCREEMGE VIKSSTFSSG 60
ANDKLKWCLR VNPKGLDEES KDYLSLYLLL VSCPKSEVRA KFKFSILNAK GEETKAMESQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGATAGGCG GAGTCTTGAG GGAGGAGGAG CAGGGAAACC CAGGGAGGGG AGGGGAGGAG 60
AAGGGAGTAA TGGGGAGGAG GCCGCGCGGG GTGGGGTCTG GCGGTACGCG CTGGCTGCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000210--BTB/POZ_dom
IPR002083--MATH/TRAF_dom
IPR011333--SKP1/BTB/POZ
IPR034089--SPOP_C
IPR008974--TRAF-like

PROSITE

PS50097--BTB
PS50144--MATH

Pfam

PF00651--BTB
PF00917--MATH

SMART

SM00225--BTB
SM00061--MATH

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0042593--P:glucose homeostasis
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:2000676--P:positive regulation of type B pancreatic cell apoptotic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis

KEGG

hsa:8405

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000920	Aegilops tauschii	31.53	3.00e-40	159.00
IUUC-Aml-002307	Ailuropoda melanoleuca	95.17	0.00e+00	700.00
IUUC-Apl-003488	Anas platyrhynchos	99.73	0.00e+00	715.00
IUUC-Aca-005010	Anolis carolinensis	99.47	0.00e+00	714.00
IUUC-Aly-005426	Arabidopsis lyrata	29.86	4.00e-41	162.00
IUUC-Afl-008594	Aspergillus flavus	38.46	2.00e-03	36.20
IUUC-Aor-009945	Aspergillus oryzae	38.46	3.00e-04	36.60
IUUC-Bgr-012157	Blumeria graminis	35.00	1.00e-04	40.40
IUUC-Bta-012931	Bos taurus	100.00	0.00e+00	716.00
IUUC-Bdi-014743	Brachypodium distachyon	32.55	3.00e-43	169.00
IUUC-Cel-018671	Caenorhabditis elegans	65.90	1.00e-135	476.00
IUUC-Cja-019981	Callithrix jacchus	99.73	0.00e+00	712.00
IUUC-Cfa-020115	Canis familiaris	100.00	0.00e+00	716.00
IUUC-Cpo-021366	Cavia porcellus	99.47	0.00e+00	710.00
IUUC-Cre-022954	Chlamydomonas reinhardtii	30.99	2.00e-06	48.50
IUUC-Cin-025636	Ciona intestinalis	76.55	3.00e-159	554.00
IUUC-Csv-026167	Ciona savignyi	71.68	4.00e-156	544.00
IUUC-Cgl-026729	Colletotrichum gloeosporioides	30.30	8.00e-06	45.10
IUUC-Dre-027603	Danio rerio	97.33	0.00e+00	697.00
IUUC-Dno-029006	Dasypus novemcinctus	93.93	0.00e+00	645.00
IUUC-Dor-030503	Dipodomys ordii	100.00	0.00e+00	707.00
IUUC-Dme-032218	Drosophila melanogaster	79.68	5.00e-160	558.00
IUUC-Ete-032328	Echinops telfairi	99.43	0.00e+00	654.00
IUUC-Eca-033238	Equus caballus	100.00	0.00e+00	716.00
IUUC-Eeu-034739	Erinaceus europaeus	83.96	6.00e-176	610.00
IUUC-Fca-035435	Felis catus	100.00	0.00e+00	716.00
IUUC-Gmo-038600	Gadus morhua	95.99	0.00e+00	692.00
IUUC-Gga-040441	Gallus gallus	99.73	0.00e+00	715.00
IUUC-Gac-041911	Gasterosteus aculeatus	96.79	0.00e+00	696.00
IUUC-Gma-043988	Glycine max	31.22	3.00e-42	166.00
IUUC-Itr-048058	Ictidomys tridecemlineatus	97.83	0.00e+00	681.00
IUUC-Lch-050241	Latimeria chalumnae	98.66	0.00e+00	709.00
IUUC-Loc-052374	Lepisosteus oculatus	98.93	0.00e+00	709.00
IUUC-Lma-053106	Leptosphaeria maculans	23.53	2.00e-08	52.00
IUUC-Laf-054192	Loxodonta africana	99.73	0.00e+00	712.00
IUUC-Mcc-055322	Macaca mulatta	100.00	0.00e+00	716.00
IUUC-Meu-056330	Macropus eugenii	92.78	0.00e+00	660.00
IUUC-Mor-057237	Magnaporthe oryzae	29.41	9.00e-08	50.80
IUUC-Mpo-057466	Magnaporthe poae	28.36	7.00e-08	50.80
IUUC-Mtr-058679	Medicago truncatula	30.14	1.00e-40	160.00
IUUC-Mga-059579	Meleagris gallopavo	95.15	0.00e+00	701.00
IUUC-Mmr-061309	Microcebus murinus	100.00	0.00e+00	716.00
IUUC-Mmu-064227	Mus musculus	100.00	0.00e+00	716.00
IUUC-Mac-065306	Musa acuminata	30.10	2.00e-43	169.00
IUUC-Mpu-065693	Mustela putorius furo	100.00	0.00e+00	716.00
IUUC-Mlu-067827	Myotis lucifugus	99.47	0.00e+00	709.00
IUUC-Nle-069393	Nomascus leucogenys	100.00	0.00e+00	716.00
IUUC-Opr-070490	Ochotona princeps	98.13	0.00e+00	699.00
IUUC-Ont-071726	Oreochromis niloticus	97.06	0.00e+00	698.00
IUUC-Ocu-074932	Oryctolagus cuniculus	100.00	0.00e+00	716.00
IUUC-Obr-076031	Oryza brachyantha	28.65	1.00e-32	134.00
IUUC-Ogu-078752	Oryza glumaepatula	34.62	2.00e-38	154.00
IUUC-Olo-080833	Oryza longistaminata	32.56	2.00e-37	149.00
IUUC-Ome-081184	Oryza meridionalis	33.33	1.00e-38	155.00
IUUC-Opu-083303	Oryza punctata	32.20	8.00e-29	122.00
IUUC-Oru-085193	Oryza rufipogon	30.68	4.00e-41	164.00
IUUC-Ola-086989	Oryzias latipes	96.80	0.00e+00	693.00
IUUC-Olu-087691	Ostreococcus lucimarinus	31.73	2.00e-35	142.00
IUUC-Oga-089107	Otolemur garnettii	100.00	0.00e+00	716.00
IUUC-Oar-089943	Ovis aries	99.73	0.00e+00	712.00
IUUC-Ptr-091201	Pan troglodytes	100.00	0.00e+00	716.00
IUUC-Pan-092504	Papio anubis	100.00	0.00e+00	716.00
IUUC-Psi-093063	Pelodiscus sinensis	99.73	0.00e+00	715.00
IUUC-Pma-094310	Petromyzon marinus	85.24	7.00e-169	586.00
IUUC-Ppa-095322	Physcomitrella patens	31.56	2.00e-41	163.00
IUUC-Pfo-096411	Poecilia formosa	97.06	0.00e+00	698.00
IUUC-Pab-098640	Pongo abelii	100.00	0.00e+00	716.00
IUUC-Pop-099525	Populus trichocarpa	31.27	5.00e-30	125.00
IUUC-Pca-100243	Procavia capensis	84.04	4.00e-131	460.00
IUUC-Pva-102296	Pteropus vampyrus	93.05	0.00e+00	649.00
IUUC-Pyt-104526	Pyrenophora triticirepentis	23.53	1.00e-06	47.40
IUUC-Rno-105399	Rattus norvegicus	100.00	0.00e+00	716.00
IUUC-Sha-106700	Sarcophilus harrisii	99.47	0.00e+00	713.00
IUUC-Sja-107711	Schizosaccharomyces japonicus	27.42	6.00e-03	34.70
IUUC-Spo-108262	Schizosaccharomyces pombe	36.84	1.20e-01	32.00
IUUC-Ssl-108548	Sclerotinia sclerotiorum	28.77	2.00e-06	47.00
IUUC-Smo-108684	Selaginella moellendorffii	31.52	7.00e-31	128.00
IUUC-Sit-109872	Setaria italica	33.43	1.00e-41	164.00
IUUC-Sly-110931	Solanum lycopersicum	30.53	6.00e-43	168.00
IUUC-Stu-112216	Solanum tuberosum	31.09	1.00e-42	167.00
IUUC-Sar-113489	Sorex araneus	100.00	0.00e+00	716.00
IUUC-Sbi-114217	Sorghum bicolor	32.80	3.00e-44	172.00
IUUC-Tru-117832	Takifugu rubripes	96.26	0.00e+00	692.00
IUUC-Tsy-118969	Tarsius syrichta	94.92	0.00e+00	671.00
IUUC-Tni-120221	Tetraodon nigroviridis	96.26	0.00e+00	692.00
IUUC-Tca-121715	Theobroma cacao	30.93	1.00e-44	173.00
IUUC-Tae-122976	Triticum aestivum	32.39	8.00e-41	161.00
IUUC-Tbe-127298	Tupaia belangeri	99.47	0.00e+00	702.00
IUUC-Ttr-128952	Tursiops truncatus	99.73	0.00e+00	715.00
IUUC-Vda-129835	Verticillium dahliae	42.00	8.00e-07	49.30
IUUC-Vpa-130735	Vicugna pacos	94.12	0.00e+00	644.00
IUUC-Vvi-130854	Vitis vinifera	31.65	6.00e-32	131.00
IUUC-Xtr-132806	Xenopus tropicalis	98.14	0.00e+00	702.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence