iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000100263.13	ENST00000216085.11	ENSP00000216085.7
ENSG00000100263.13	ENST00000413137.6	ENSP00000399550.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	CircNet	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	HINT	Mentha	InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	dbPTM	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	24859449

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	9.00e-05	24.1	329	360

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 7    leqlveMGFdreealqaLraannnleaAveyLl 39
           l+ql+ MGF++e+a+ aL+a  + +e Av +L 
   Q: 329  LQQLERMGFPTEQAVVALAA-TGRVEGAVSLLV 360
           9*******************.7*******9997 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MHARGPHGQL SPALPLASSV LMLLMSTLWL VGAGPGLVLA PELLLDPWQV HRLLTHALGH 60
TALPGLLLSL LLLPTVGWQQ ECHLGTLRFL HASALLALAS GLLAVLLAGL GLSSAAGSCG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCAGGAGGGA TGAACCACCG CTTACTCGTT CTTCGCGTCC GCAACTCTTG TCCCAGTCCT 60
CTCTAAAGAG CGCCCGACGT GACACTCGGG CCAAAATAGC ATCTAAGGGG CCAGAGCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR022764--Peptidase_S54_rhomboid_dom
IPR015940--UBA
IPR009060--UBA-like

Pfam

PF01694--Rhomboid
PF00627--UBA

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005622--C:intracellular
GO:0004252--F:serine-type endopeptidase activity
GO:0001889--P:liver development
GO:0000165--P:MAPK cascade
GO:0032815--P:negative regulation of natural killer cell activation
GO:0045732--P:positive regulation of protein catabolic process
GO:0002673--P:regulation of acute inflammatory response
GO:0050708--P:regulation of protein secretion
GO:0009410--P:response to xenobiotic stimulus

KEGG

hsa:25807

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001619	Ailuropoda melanoleuca	84.02	4.00e-81	295.00
IUUC-Aca-004494	Anolis carolinensis	41.05	8.00e-24	104.00
IUUC-Ame-010805	Astyanax mexicanus	56.32	2.00e-18	87.00
IUUC-Bta-012844	Bos taurus	83.28	5.00e-64	238.00
IUUC-Cja-019853	Callithrix jacchus	90.67	3.00e-105	375.00
IUUC-Cfa-021026	Canis familiaris	82.25	2.00e-93	335.00
IUUC-Csa-023360	Chlorocebus sabaeus	93.78	2.00e-118	419.00
IUUC-Dre-027575	Danio rerio	59.55	1.00e-20	94.00
IUUC-Dno-029113	Dasypus novemcinctus	78.98	3.00e-74	271.00
IUUC-Dor-030646	Dipodomys ordii	80.21	7.00e-102	363.00
IUUC-Eca-034158	Equus caballus	84.18	1.00e-100	359.00
IUUC-Eeu-034983	Erinaceus europaeus	64.73	1.00e-54	205.00
IUUC-Fca-035531	Felis catus	83.33	3.00e-102	365.00
IUUC-Fox-037714	Fusarium oxysporum	35.09	5.00e-03	35.80
IUUC-Ggo-045015	Gorilla gorilla	99.22	4.00e-124	437.00
IUUC-Itr-048164	Ictidomys tridecemlineatus	80.83	3.00e-96	345.00
IUUC-Lch-049560	Latimeria chalumnae	35.39	4.00e-16	79.00
IUUC-Loc-052194	Lepisosteus oculatus	38.58	2.00e-02	33.50
IUUC-Laf-054308	Loxodonta africana	81.87	2.00e-89	322.00
IUUC-Mcc-055034	Macaca mulatta	80.42	3.00e-86	311.00
IUUC-Meu-056317	Macropus eugenii	49.66	6.00e-32	131.00
IUUC-Mor-057124	Magnaporthe oryzae	45.71	1.10e-01	33.50
IUUC-Mmr-061591	Microcebus murinus	83.79	3.00e-73	269.00
IUUC-Mdo-062745	Monodelphis domestica	52.91	9.00e-38	150.00
IUUC-Mmu-063304	Mus musculus	76.35	3.00e-92	332.00
IUUC-Mac-065073	Musa acuminata	45.71	5.30e-01	29.60
IUUC-Mpu-066394	Mustela putorius furo	82.89	7.00e-94	337.00
IUUC-Mlu-067595	Myotis lucifugus	79.38	8.00e-95	340.00
IUUC-Nle-069211	Nomascus leucogenys	94.50	7.00e-120	423.00
IUUC-Opr-070249	Ochotona princeps	67.98	7.00e-66	243.00
IUUC-Oan-073402	Ornithorhynchus anatinus	59.80	8.00e-07	46.60
IUUC-Ocu-074418	Oryctolagus cuniculus	76.94	1.00e-91	330.00
IUUC-Obr-076453	Oryza brachyantha	28.38	2.70e-01	30.80
IUUC-Ola-087450	Oryzias latipes	53.66	4.00e-18	84.70
IUUC-Oga-088214	Otolemur garnettii	82.67	1.00e-102	366.00
IUUC-Oar-089324	Ovis aries	82.28	8.00e-32	130.00
IUUC-Ptr-091322	Pan troglodytes	98.04	3.00e-97	348.00
IUUC-Pan-092490	Papio anubis	93.01	1.00e-128	452.00
IUUC-Pfo-097125	Poecilia formosa	53.49	1.00e-17	83.60
IUUC-Pab-097546	Pongo abelii	96.92	1.00e-39	155.00
IUUC-Ppe-101260	Prunus persica	28.41	9.00e-02	31.60
IUUC-Pva-102615	Pteropus vampyrus	81.82	4.00e-99	354.00
IUUC-Rno-105844	Rattus norvegicus	77.49	6.00e-91	327.00
IUUC-Sha-107118	Sarcophilus harrisii	51.66	7.00e-22	97.40
IUUC-Ssc-115786	Sus scrofa	84.32	4.00e-99	355.00
IUUC-Ttr-128407	Tursiops truncatus	80.94	7.00e-90	324.00
IUUC-Xtr-131878	Xenopus tropicalis	59.76	5.00e-18	85.50

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence