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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063969
Ensembl Protein ID ENSMUSP00000022078.5
UniProt Accession Q9CTN4; Q05DP2; Q3UTS4; Q80X55; Q9CVT0; RHBT3_MOUSE
Genbank Protein ID BAC98044.1; BAB24689.1; BAE23906.1; EDL37111.1; AAH05664.1; AAH50836.1
Protein Name Rho-related BTB domain-containing protein 3
Genbank Nucleotide ID AK129234; AK020938; AK139158; CH466563; BC005664; BC050836
Gene Name Rhobtb3; Kiaa0878
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000021589.12 ENSMUST00000022078.11 ENSMUSP00000022078.5
ENSMUSG00000021589.12 ENSMUST00000109606.1 ENSMUSP00000105235.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 1.30e-25 90.7 420 482
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgk 64
           aDv+++++g  ++ah+++L a+++v+ a+f+++  e k +  + + +v+ e f  +l++lYt++
   Q: 420  ADVVFEIQGATVPAHRAILVARCEVMAAMFNGNYMEAK-SVLIPVYGVSKETFLSFLEYLYTDS 482
           7***********************************99.55566667***************86 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9 (By similarity).
 Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9 (By similarity).
Protein Sequence
(Fasta)
MSIHIVALGN EGDTFHQDNR PSGLIRTYLG RSPLVSGDES SLLLNAASTV ARPVFTEYQA 60
SAFGNVKLVV HDCPVWDIFD SDWYTSRNLI GGADIIVIKY NVNDKFSFHE VKDNYIPVIK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063969|E3,BTB_Other|Mus musculus
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Nucleotide Sequence
(Fasta)
GAGGAAACTT GCTGCAGGCG GATTGGCGGC GAGCTGCTCC CGGGCTCCGG CGTCGTCCCC 60
GCGCCCACCG CTCCTTTGTG TCCCGCGGCC TCGGCCAGCA GCCAGCTCCC CCGCGCGCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063969|E3,BTB_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
Interpro

IPR000210--BTB/POZ_dom
IPR027417--P-loop_NTPase
IPR031260--RhoBTB3
IPR011333--SKP1/BTB/POZ
IPR001806--Small_GTPase
PROSITE

PS50097--BTB
Pfam

PF00651--BTB
PF00071--Ras
SMART

SM00225--BTB
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0017137--F:Rab GTPase binding
GO:0008584--P:male gonad development
GO:0042147--P:retrograde transport, endosome to Golgi
GO:0007264--P:small GTPase mediated signal transduction
KEGG mmu:73296
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001703 Ailuropoda melanoleuca 95.25 0.00e+00 1224.00
IUUC-Apl-003597 Anas platyrhynchos 72.07 0.00e+00 759.00
IUUC-Aca-005165 Anolis carolinensis 73.74 0.00e+00 894.00
IUUC-Ame-011844 Astyanax mexicanus 43.77 4.00e-129 455.00
IUUC-Bta-013209 Bos taurus 92.81 0.00e+00 1177.00
IUUC-Cja-019287 Callithrix jacchus 95.42 0.00e+00 1228.00
IUUC-Cfa-021000 Canis familiaris 93.53 0.00e+00 824.00
IUUC-Cpo-022105 Cavia porcellus 91.01 0.00e+00 1145.00
IUUC-Csa-023505 Chlorocebus sabaeus 95.42 0.00e+00 1228.00
IUUC-Cho-024673 Choloepus hoffmanni 88.05 0.00e+00 1088.00
IUUC-Dre-028304 Danio rerio 45.57 5.00e-148 518.00
IUUC-Dno-029451 Dasypus novemcinctus 91.57 0.00e+00 1172.00
IUUC-Dor-030155 Dipodomys ordii 84.62 0.00e+00 1064.00
IUUC-Ete-033024 Echinops telfairi 83.14 0.00e+00 1054.00
IUUC-Eca-034120 Equus caballus 95.08 0.00e+00 1190.00
IUUC-Eeu-034621 Erinaceus europaeus 85.43 0.00e+00 1070.00
IUUC-Fca-035426 Felis catus 95.25 0.00e+00 1194.00
IUUC-Fal-037409 Ficedula albicollis 70.03 0.00e+00 873.00
IUUC-Gmo-038756 Gadus morhua 45.45 1.00e-137 483.00
IUUC-Gga-040759 Gallus gallus 71.45 0.00e+00 894.00
IUUC-Gac-041780 Gasterosteus aculeatus 47.03 3.00e-142 498.00
IUUC-Ggo-044917 Gorilla gorilla 95.90 0.00e+00 1228.00
IUUC-Hsa-046587 Homo sapiens 95.74 0.00e+00 1229.00
IUUC-Itr-048426 Ictidomys tridecemlineatus 94.62 3.00e-160 557.00
IUUC-Lch-049928 Latimeria chalumnae 54.50 0.00e+00 627.00
IUUC-Loc-052892 Lepisosteus oculatus 52.46 6.00e-137 481.00
IUUC-Laf-053969 Loxodonta africana 91.54 0.00e+00 1135.00
IUUC-Mcc-055592 Macaca mulatta 95.42 0.00e+00 1228.00
IUUC-Meu-056177 Macropus eugenii 61.94 0.00e+00 627.00
IUUC-Mga-059268 Meleagris gallopavo 52.92 5.00e-152 531.00
IUUC-Mmr-060912 Microcebus murinus 95.25 0.00e+00 1198.00
IUUC-Mdo-062861 Monodelphis domestica 78.22 0.00e+00 918.00
IUUC-Mpu-065970 Mustela putorius furo 94.93 0.00e+00 1224.00
IUUC-Mlu-067698 Myotis lucifugus 94.45 0.00e+00 1203.00
IUUC-Nle-069460 Nomascus leucogenys 95.25 0.00e+00 1227.00
IUUC-Opr-070677 Ochotona princeps 93.62 0.00e+00 1177.00
IUUC-Ont-072661 Oreochromis niloticus 45.26 2.00e-150 526.00
IUUC-Oan-073683 Ornithorhynchus anatinus 80.08 0.00e+00 857.00
IUUC-Ocu-074387 Oryctolagus cuniculus 92.65 0.00e+00 1160.00
IUUC-Ola-087205 Oryzias latipes 45.89 4.00e-147 514.00
IUUC-Oga-088541 Otolemur garnettii 93.44 0.00e+00 1173.00
IUUC-Oar-089303 Ovis aries 92.97 0.00e+00 1181.00
IUUC-Ptr-091617 Pan troglodytes 95.74 0.00e+00 1227.00
IUUC-Pan-092131 Papio anubis 95.58 0.00e+00 1229.00
IUUC-Psi-092934 Pelodiscus sinensis 75.49 0.00e+00 895.00
IUUC-Pfo-097444 Poecilia formosa 45.13 2.00e-141 496.00
IUUC-Pab-098318 Pongo abelii 94.49 0.00e+00 941.00
IUUC-Pca-100096 Procavia capensis 87.29 0.00e+00 970.00
IUUC-Pva-102344 Pteropus vampyrus 85.92 0.00e+00 1078.00
IUUC-Rno-105393 Rattus norvegicus 98.85 0.00e+00 1259.00
IUUC-Sha-106830 Sarcophilus harrisii 81.89 0.00e+00 1006.00
IUUC-Sar-113635 Sorex araneus 80.93 0.00e+00 854.00
IUUC-Ssc-115928 Sus scrofa 94.13 0.00e+00 1209.00
IUUC-Tgu-116531 Taeniopygia guttata 70.31 0.00e+00 860.00
IUUC-Tru-117997 Takifugu rubripes 45.53 8.00e-144 504.00
IUUC-Tsy-119040 Tarsius syrichta 85.60 0.00e+00 1058.00
IUUC-Tni-119855 Tetraodon nigroviridis 45.45 2.00e-143 502.00
IUUC-Tbe-127588 Tupaia belangeri 78.62 0.00e+00 656.00
IUUC-Ttr-128334 Tursiops truncatus 86.06 0.00e+00 934.00
IUUC-Vpa-130561 Vicugna pacos 91.16 0.00e+00 1134.00
IUUC-Xtr-132632 Xenopus tropicalis 58.36 7.00e-174 603.00
Created Date 25-Jun-2017

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