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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045753
Ensembl Protein ID ENSP00000356468.3
UniProt Accession Q9Y6Y0; A8K8R6; Q1G4T6; Q1G4T7; Q5TF75; Q6NW38; Q7LCG2; Q9NZX0; Q9Y480; NS1BP_HUMAN
Genbank Protein ID CAA10029.1; ABE03889.1; ABE03890.1; AAG43485.1; BAA74873.2; AAF29040.1; CAB72329.1; CAB72329.1; BAF85120.1; CAI17867.1; CAI22094.1; CAI22094.1; EAW91194.1; AAH67739.1
Protein Name Influenza virus NS1A-binding protein; Aryl hydrocarbon receptor-associated protein 3
Genbank Nucleotide ID AJ012449; DQ443528; DQ443529; AF205218; AB020657; AF161553; AL078644; AL356273; AK292431; AL078644; AL356273; AL078644; CH471067; BC067739
Gene Name IVNS1ABP; ARA3; FLARA3; KIAA0850; NS1; NS1BP; HSPC068
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000116679.15 ENST00000367498.7 ENSP00000356468.3
ENSG00000116679.15 ENST00000422754.1 ENSP00000401826.1
ENSG00000116679.15 ENST00000367497.1 ENSP00000356467.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Disease-associated Variation
GWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 1.70e-11 46.0 32 96
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkld 66
           +Dv l+v g e  ah++vLa +S+++   f+++ +     + v+++d+ pe++++ll++ Yt +l+
   Q: 32   CDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHG-ISHVKFDDLNPEAVEVLLNYAYTAQLK 96
           8**********************************776.9************************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription.
 Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription.
Protein Sequence
(Fasta)
MIPNGYLMFE DENFIESSVA KLNALRKSGQ FCDVRLQVCG HEMLAHRAVL ACCSPYLFEI 60
FNSDSDPHGI SHVKFDDLNP EAVEVLLNYA YTAQLKADKE LVKDVYSAAK KLKMDRVKQV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045753|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAAGCGGGCT GGGAGGCGTC GGCGGCGGCA GCGCACGTGG TGACGTGCGA GGGGGTGCGG 60
CGCGAGCGGT CGGCGGCGGC GGAGGCAGTG TCTCCCGGTC GCGCGTGGAG GTCGGTCGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045753|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0945--Host-virus interaction
KW-0880--Kelch repeat
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR029849--NS1BP
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005681--C:spliceosomal complex
GO:0005667--C:transcription factor complex
GO:2001243--P:negative regulation of intrinsic apoptotic signaling pathway
GO:0009615--P:response to virus
GO:0008380--P:RNA splicing
GO:0006383--P:transcription from RNA polymerase III promoter
KEGG hsa:10625
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001227 Ailuropoda melanoleuca 98.13 0.00e+00 1317.00
IUUC-Apl-003244 Anas platyrhynchos 90.06 0.00e+00 1209.00
IUUC-Aca-005134 Anolis carolinensis 89.56 0.00e+00 1196.00
IUUC-Ame-011309 Astyanax mexicanus 76.95 0.00e+00 1042.00
IUUC-Bta-013020 Bos taurus 97.20 0.00e+00 1286.00
IUUC-Cel-018672 Caenorhabditis elegans 27.71 5.00e-80 292.00
IUUC-Cja-018717 Callithrix jacchus 98.44 0.00e+00 1274.00
IUUC-Cfa-021209 Canis familiaris 97.98 0.00e+00 1291.00
IUUC-Cpo-022465 Cavia porcellus 97.20 0.00e+00 1290.00
IUUC-Csa-023264 Chlorocebus sabaeus 99.69 0.00e+00 1288.00
IUUC-Cho-024407 Choloepus hoffmanni 96.77 0.00e+00 1095.00
IUUC-Dre-027945 Danio rerio 77.73 0.00e+00 1057.00
IUUC-Dno-028942 Dasypus novemcinctus 92.21 0.00e+00 1207.00
IUUC-Ete-032283 Echinops telfairi 96.26 0.00e+00 1274.00
IUUC-Eca-033877 Equus caballus 97.20 0.00e+00 996.00
IUUC-Eeu-034923 Erinaceus europaeus 89.25 0.00e+00 1160.00
IUUC-Fca-036378 Felis catus 97.82 0.00e+00 1293.00
IUUC-Fal-037161 Ficedula albicollis 87.10 0.00e+00 997.00
IUUC-Gmo-039396 Gadus morhua 69.77 0.00e+00 870.00
IUUC-Gga-040338 Gallus gallus 94.55 6.00e-123 432.00
IUUC-Gac-042553 Gasterosteus aculeatus 74.96 0.00e+00 966.00
IUUC-Ggo-045612 Gorilla gorilla 99.84 0.00e+00 1289.00
IUUC-Hvu-047224 Hordeum vulgare 33.21 2.00e-38 154.00
IUUC-Itr-048475 Ictidomys tridecemlineatus 98.13 0.00e+00 1321.00
IUUC-Lch-050220 Latimeria chalumnae 78.70 0.00e+00 1022.00
IUUC-Loc-051950 Lepisosteus oculatus 80.00 0.00e+00 1089.00
IUUC-Laf-053878 Loxodonta africana 96.88 0.00e+00 1283.00
IUUC-Mcc-055598 Macaca mulatta 99.53 0.00e+00 1288.00
IUUC-Meu-056133 Macropus eugenii 98.80 1.00e-145 509.00
IUUC-Mga-059538 Meleagris gallopavo 89.13 0.00e+00 1174.00
IUUC-Mmr-061279 Microcebus murinus 97.66 0.00e+00 1263.00
IUUC-Mdo-062952 Monodelphis domestica 94.86 0.00e+00 1267.00
IUUC-Mmu-063566 Mus musculus 97.04 0.00e+00 1255.00
IUUC-Mpu-065828 Mustela putorius furo 97.98 0.00e+00 1295.00
IUUC-Mlu-067313 Myotis lucifugus 96.58 0.00e+00 1242.00
IUUC-Nle-069890 Nomascus leucogenys 99.84 0.00e+00 1290.00
IUUC-Ont-072649 Oreochromis niloticus 76.33 0.00e+00 998.00
IUUC-Oan-073447 Ornithorhynchus anatinus 93.94 0.00e+00 1217.00
IUUC-Ocu-074680 Oryctolagus cuniculus 90.91 0.00e+00 1156.00
IUUC-Obr-076181 Oryza brachyantha 32.17 2.00e-35 145.00
IUUC-Ogu-078293 Oryza glumaepatula 29.05 3.00e-12 66.60
IUUC-Ome-081207 Oryza meridionalis 29.05 2.00e-12 66.60
IUUC-Oni-082785 Oryza nivara 29.05 3.00e-12 66.20
IUUC-Oru-084871 Oryza rufipogon 29.05 3.00e-12 66.20
IUUC-Ola-086588 Oryzias latipes 75.27 0.00e+00 994.00
IUUC-Oga-088982 Otolemur garnettii 97.98 0.00e+00 1298.00
IUUC-Oar-090409 Ovis aries 97.35 0.00e+00 1289.00
IUUC-Ptr-091365 Pan troglodytes 99.69 0.00e+00 1289.00
IUUC-Pan-092753 Papio anubis 99.69 0.00e+00 1288.00
IUUC-Pma-094393 Petromyzon marinus 71.95 3.00e-89 320.00
IUUC-Pfo-096772 Poecilia formosa 76.52 0.00e+00 1011.00
IUUC-Pab-098516 Pongo abelii 99.84 0.00e+00 1290.00
IUUC-Pca-100604 Procavia capensis 87.46 0.00e+00 1113.00
IUUC-Pva-102388 Pteropus vampyrus 97.35 0.00e+00 1258.00
IUUC-Rno-105464 Rattus norvegicus 97.51 0.00e+00 1261.00
IUUC-Sha-107436 Sarcophilus harrisii 94.73 0.00e+00 1254.00
IUUC-Tgu-116590 Taeniopygia guttata 84.89 0.00e+00 1132.00
IUUC-Tru-117699 Takifugu rubripes 76.49 0.00e+00 1039.00
IUUC-Tsy-119465 Tarsius syrichta 96.57 0.00e+00 1247.00
IUUC-Tni-120314 Tetraodon nigroviridis 75.86 0.00e+00 1028.00
IUUC-Tbe-127336 Tupaia belangeri 95.95 0.00e+00 1226.00
IUUC-Ttr-128624 Tursiops truncatus 90.50 0.00e+00 1139.00
IUUC-Vpa-130453 Vicugna pacos 97.66 0.00e+00 1248.00
IUUC-Xtr-132900 Xenopus tropicalis 77.78 0.00e+00 1051.00
IUUC-Xma-133881 Xiphophorus maculatus 75.74 0.00e+00 1002.00
Created Date 25-Jun-2017

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