iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000275618.2	ENST00000619034.2	ENSP00000478190.1
ENSG00000275618.2	ENST00000632391.1	ENSP00000487878.1
ENSG00000275618.2	ENST00000631651.1	ENSP00000488143.1
ENSG00000275618.2	ENST00000633638.1	ENSP00000488487.1
ENSG00000275618.2	ENST00000632031.1	ENSP00000488492.1

Annotation

Cancer Mutation
TCGA	COSMIC	CGAP	IntOGen
mRNA Expression
TCGA	ICGC	COSMIC
DNA & RNA Element
UTRdb	circRNADb	CircNet	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
InWeb_IM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18805781; 21068390

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.00023	23.3	34	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C  C++ + + p +l+CgH f+++Cl  w      ssk+  CP Cr
   Q: 34   CHCCYDILVN-PTTLNCGHSFCRHCLALW----WASSKKTECPECR 74
           889*****99.999************888....78999999****8 PP

Organism

Homo sapiens

Functional Description
(View)

Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors.

Protein Sequence
(Fasta)

MEEPQKSYVN TMDLERDEPL KSTGPQISVS EFSCHCCYDI LVNPTTLNCG HSFCRHCLAL 60
WWASSKKTEC PECREKWEGF PKVSILLRDA IEKLFPDAIR LRFEDIQQNN DIVQSLAAFQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGCCGCTC TAGGCAGCGG GGAGGTCGCG GGGTTGAGGG GGGTTGTGAA AGGAGAGCGG 60
CCTCTCCTCT ATGGTCACGG GGCCGGGGCA CGCTTCCCCC ACTCTGTCTT GTTACTTCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001660--SAM
IPR013761--SAM/pointed
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50105--SAM_DOMAIN
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00536--SAM_1

SMART

SM00184--RING
SM00454--SAM

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0005887--C:integral component of plasma membrane
GO:0016020--C:membrane
GO:0089720--F:caspase binding
GO:0030674--F:protein binding, bridging
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0043066--P:negative regulation of apoptotic process
GO:1903895--P:negative regulation of IRE1-mediated unfolded protein response
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

hsa:51283

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001856	Ailuropoda melanoleuca	92.67	0.00e+00	807.00
IUUC-Apl-004001	Anas platyrhynchos	78.59	0.00e+00	707.00
IUUC-Aca-005095	Anolis carolinensis	78.55	0.00e+00	687.00
IUUC-Aly-005558	Arabidopsis lyrata	38.10	4.00e-11	62.80
IUUC-Ath-007116	Arabidopsis thaliana	33.66	5.00e-11	62.00
IUUC-Ame-010623	Astyanax mexicanus	65.25	2.00e-151	528.00
IUUC-Bgr-012267	Blumeria graminis	39.06	2.00e-09	58.20
IUUC-Bta-012806	Bos taurus	90.44	0.00e+00	789.00
IUUC-Bol-015948	Brassica oleracea	32.11	6.00e-11	62.00
IUUC-Bra-017661	Brassica rapa	36.47	3.00e-11	62.80
IUUC-Cel-018107	Caenorhabditis elegans	36.07	3.00e-06	46.20
IUUC-Cja-019478	Callithrix jacchus	92.67	0.00e+00	821.00
IUUC-Cfa-021253	Canis familiaris	92.89	0.00e+00	806.00
IUUC-Cpo-022551	Cavia porcellus	92.44	0.00e+00	806.00
IUUC-Cre-022763	Chlamydomonas reinhardtii	31.87	2.00e-09	54.70
IUUC-Csa-023499	Chlorocebus sabaeus	98.00	0.00e+00	848.00
IUUC-Cho-024665	Choloepus hoffmanni	89.97	5.00e-154	536.00
IUUC-Dno-029161	Dasypus novemcinctus	92.44	0.00e+00	804.00
IUUC-Dor-030580	Dipodomys ordii	93.37	0.00e+00	635.00
IUUC-Ete-032643	Echinops telfairi	83.56	0.00e+00	739.00
IUUC-Eca-034435	Equus caballus	93.33	0.00e+00	810.00
IUUC-Eeu-034787	Erinaceus europaeus	64.37	1.00e-88	320.00
IUUC-Fca-035970	Felis catus	92.67	0.00e+00	804.00
IUUC-Fal-036727	Ficedula albicollis	81.34	0.00e+00	720.00
IUUC-Gmo-039048	Gadus morhua	66.03	7.00e-167	580.00
IUUC-Gga-041098	Gallus gallus	83.48	1.00e-115	409.00
IUUC-Gac-042246	Gasterosteus aculeatus	64.71	2.00e-158	551.00
IUUC-Ggo-045045	Gorilla gorilla	99.33	0.00e+00	854.00
IUUC-Itr-049066	Ictidomys tridecemlineatus	94.44	0.00e+00	815.00
IUUC-Lch-050654	Latimeria chalumnae	78.30	0.00e+00	659.00
IUUC-Loc-051851	Lepisosteus oculatus	68.46	6.00e-178	616.00
IUUC-Lma-052991	Leptosphaeria maculans	34.43	3.00e-07	51.20
IUUC-Laf-053600	Loxodonta africana	92.89	0.00e+00	809.00
IUUC-Mcc-054824	Macaca mulatta	98.22	0.00e+00	849.00
IUUC-Meu-056707	Macropus eugenii	87.92	1.00e-146	512.00
IUUC-Mtr-058729	Medicago truncatula	35.16	1.00e-08	53.90
IUUC-Mga-059577	Meleagris gallopavo	83.37	0.00e+00	722.00
IUUC-Mmr-061031	Microcebus murinus	94.00	0.00e+00	818.00
IUUC-Mdo-062696	Monodelphis domestica	86.22	0.00e+00	775.00
IUUC-Mmu-063190	Mus musculus	90.00	0.00e+00	847.00
IUUC-Mpu-065811	Mustela putorius furo	92.00	0.00e+00	795.00
IUUC-Mlu-067273	Myotis lucifugus	90.44	0.00e+00	813.00
IUUC-Nle-069226	Nomascus leucogenys	98.44	0.00e+00	849.00
IUUC-Opr-071014	Ochotona princeps	91.11	0.00e+00	804.00
IUUC-Ont-072113	Oreochromis niloticus	66.67	4.00e-167	580.00
IUUC-Oan-072720	Ornithorhynchus anatinus	77.99	3.00e-165	574.00
IUUC-Ocu-073920	Oryctolagus cuniculus	89.51	0.00e+00	744.00
IUUC-Ola-087064	Oryzias latipes	64.11	1.00e-158	552.00
IUUC-Oga-088121	Otolemur garnettii	93.33	0.00e+00	813.00
IUUC-Oar-090404	Ovis aries	90.67	0.00e+00	786.00
IUUC-Ptr-090824	Pan troglodytes	99.33	0.00e+00	855.00
IUUC-Pan-091820	Papio anubis	98.22	0.00e+00	849.00
IUUC-Psi-093328	Pelodiscus sinensis	86.35	0.00e+00	738.00
IUUC-Pma-094362	Petromyzon marinus	55.24	2.00e-133	469.00
IUUC-Pno-094961	Phaeosphaeria nodorum	36.07	3.00e-08	55.10
IUUC-Ppa-095945	Physcomitrella patens	40.85	7.00e-10	58.50
IUUC-Pfo-096138	Poecilia formosa	64.19	1.00e-164	572.00
IUUC-Pab-097808	Pongo abelii	98.22	0.00e+00	845.00
IUUC-Pca-100409	Procavia capensis	88.89	0.00e+00	753.00
IUUC-Pva-103043	Pteropus vampyrus	93.36	0.00e+00	790.00
IUUC-Rno-105559	Rattus norvegicus	90.22	0.00e+00	853.00
IUUC-Sha-107404	Sarcophilus harrisii	74.78	0.00e+00	681.00
IUUC-Ssc-115421	Sus scrofa	87.15	7.00e-149	519.00
IUUC-Tgu-116564	Taeniopygia guttata	82.63	0.00e+00	715.00
IUUC-Tru-118271	Takifugu rubripes	63.72	4.00e-145	507.00
IUUC-Tsy-119122	Tarsius syrichta	95.24	4.00e-106	378.00
IUUC-Tni-120019	Tetraodon nigroviridis	62.73	1.00e-140	493.00
IUUC-Tme-126916	Tuber melanosporum	42.62	1.00e-09	58.90
IUUC-Tbe-127449	Tupaia belangeri	94.00	0.00e+00	816.00
IUUC-Ttr-128570	Tursiops truncatus	91.99	2.00e-176	611.00
IUUC-Vpa-130501	Vicugna pacos	95.02	0.00e+00	733.00
IUUC-Vvi-131151	Vitis vinifera	33.71	1.00e-08	54.70
IUUC-Xtr-132154	Xenopus tropicalis	74.34	0.00e+00	679.00
IUUC-Xma-133774	Xiphophorus maculatus	62.15	5.00e-159	553.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence