iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-061819

UUCD1 version

UUC-MoD-00156

Ensembl Protein ID

ENSMODP00000002295.3

UniProt Accession

F6S5F8; F6S5F8_MONDO

Protein Name

Uncharacterized protein

Gene Name

SOCS3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000001881.3	ENSMODT00000002343.3	ENSMODP00000002295.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	89.33	3.00e-112	402.00	IUUC-Hsa-046909

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MVTHSKFPAT GMNRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA VTGGEANLLL 60
SAEPAGTFLI RDSSDQRHFF TLSVKTQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTAACCC ACAGCAAGTT CCCCGCCACC GGGATGAACC GCCCCCTGGA CACCAGTCTG 60
CGCCTCAAGA CCTTCAGCTC CAAGAGCGAG TACCAGCTGG TGGTGAACGC TGTACGCAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028414--SOCS3
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0060670--P:branching involved in labyrinthine layer morphogenesis
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0043066--P:negative regulation of apoptotic process
GO:0050728--P:negative regulation of inflammatory response
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0060674--P:placenta blood vessel development
GO:0045597--P:positive regulation of cell differentiation
GO:0016567--P:protein ubiquitination
GO:0060708--P:spongiotrophoblast differentiation
GO:0060707--P:trophoblast giant cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001529	Ailuropoda melanoleuca	88.89	3.00e-105	374.00
IUUC-Apl-003607	Anas platyrhynchos	81.78	6.00e-96	342.00
IUUC-Aca-005063	Anolis carolinensis	79.39	1.00e-99	355.00
IUUC-Ath-006990	Arabidopsis thaliana	32.94	7.00e-03	36.20
IUUC-Ame-010859	Astyanax mexicanus	55.65	7.00e-68	249.00
IUUC-Bta-012817	Bos taurus	87.34	1.00e-107	382.00
IUUC-Cja-019605	Callithrix jacchus	90.22	6.00e-112	396.00
IUUC-Cfa-021231	Canis familiaris	88.89	5.00e-106	376.00
IUUC-Cpo-022003	Cavia porcellus	87.72	2.00e-104	371.00
IUUC-Csa-023511	Chlorocebus sabaeus	89.33	6.00e-110	389.00
IUUC-Dre-028536	Danio rerio	58.26	3.00e-71	261.00
IUUC-Dno-029003	Dasypus novemcinctus	87.56	8.00e-107	379.00
IUUC-Eca-034205	Equus caballus	81.01	3.00e-66	243.00
IUUC-Fca-036317	Felis catus	86.55	2.00e-105	374.00
IUUC-Gmo-038777	Gadus morhua	63.89	9.00e-36	142.00
IUUC-Gga-041258	Gallus gallus	81.78	9.00e-96	342.00
IUUC-Gac-041837	Gasterosteus aculeatus	54.15	4.00e-64	237.00
IUUC-Ggo-045620	Gorilla gorilla	89.33	6.00e-110	389.00
IUUC-Hsa-046909	Homo sapiens	89.33	6.00e-110	389.00
IUUC-Itr-048023	Ictidomys tridecemlineatus	85.47	2.00e-108	384.00
IUUC-Lch-049510	Latimeria chalumnae	65.50	3.00e-81	294.00
IUUC-Loc-052863	Lepisosteus oculatus	61.74	1.00e-76	278.00
IUUC-Laf-054136	Loxodonta africana	86.84	4.00e-106	376.00
IUUC-Mcc-055383	Macaca mulatta	89.33	6.00e-110	389.00
IUUC-Meu-056153	Macropus eugenii	96.90	4.00e-117	413.00
IUUC-Mmr-061185	Microcebus murinus	88.50	3.00e-104	370.00
IUUC-Mmu-064231	Mus musculus	88.89	5.00e-111	393.00
IUUC-Mpu-066691	Mustela putorius furo	89.33	5.00e-106	376.00
IUUC-Mlu-067673	Myotis lucifugus	86.28	4.00e-109	386.00
IUUC-Ont-072406	Oreochromis niloticus	53.28	4.00e-66	243.00
IUUC-Oan-073249	Ornithorhynchus anatinus	76.89	3.00e-93	333.00
IUUC-Ocu-074935	Oryctolagus cuniculus	84.06	4.00e-31	125.00
IUUC-Ola-087373	Oryzias latipes	46.60	3.00e-47	181.00
IUUC-Oga-088041	Otolemur garnettii	88.00	2.00e-106	378.00
IUUC-Oar-089646	Ovis aries	86.03	2.00e-100	357.00
IUUC-Ptr-091502	Pan troglodytes	89.33	6.00e-110	389.00
IUUC-Pan-091934	Papio anubis	89.33	6.00e-110	389.00
IUUC-Pfo-096412	Poecilia formosa	41.92	6.00e-47	180.00
IUUC-Pab-098554	Pongo abelii	89.33	6.00e-110	389.00
IUUC-Rno-105874	Rattus norvegicus	89.33	7.00e-112	395.00
IUUC-Sha-107151	Sarcophilus harrisii	95.61	2.00e-116	410.00
IUUC-Ssc-115722	Sus scrofa	78.49	6.00e-64	236.00
IUUC-Tgu-117151	Taeniopygia guttata	81.33	6.00e-95	339.00
IUUC-Tru-118428	Takifugu rubripes	52.84	8.00e-66	242.00
IUUC-Tni-120590	Tetraodon nigroviridis	53.28	5.00e-65	239.00
IUUC-Ttr-129065	Tursiops truncatus	89.08	3.00e-108	384.00
IUUC-Xtr-132167	Xenopus tropicalis	65.78	8.00e-81	292.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence