iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000044949.7	ENSDART00000066072.5	ENSDARP00000066071.4
ENSDARG00000044949.7	ENSDART00000151429.1	ENSDARP00000125628.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.90e-06	29.2	392	429

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C+iC e f +  ++l+C H f+++C+  w       +++++CP C
   Q: 392  CSICSELFIE-AVTLNCAHSFCQHCISEW------RNRKDKCPMC 429
           ********99.899***************......********** PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MEKTEEPPSS NNEEDSPAKE KIWCLQRVGR DSDWLRLFED SEVSVGRGLN VTHQILSSSC 60
PLMISRIHCV FKLNEGRQWT VTDNKSLNGV WVNGKRIPPS SPCILHQSDS VRLGVPLDGN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGTGCTGT GTTCTTGTGA AAAGCTCTTG CGCAGCTTTC ATGGCGGAAT GTGGCGGACA 60
ACACACAATA AAAACAACAT AATTTGGCAT GAATTAATGG AGCAGGAATA ATGGAAAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000253--FHA_dom
IPR017335--RNF8
IPR008984--SMAD_FHA_domain
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50006--FHA_DOMAIN
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00498--FHA
PF00097--zf-C3HC4

SMART

SM00240--FHA
SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0006302--P:double-strand break repair
GO:0070534--P:protein K63-linked ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002124	Ailuropoda melanoleuca	59.88	2.00e-35	143.00
IUUC-Apl-003664	Anas platyrhynchos	69.39	2.00e-34	137.00
IUUC-Aca-005036	Anolis carolinensis	41.98	1.00e-71	264.00
IUUC-Ame-011537	Astyanax mexicanus	65.96	4.00e-151	528.00
IUUC-Bta-013297	Bos taurus	63.57	3.00e-40	159.00
IUUC-Cja-019201	Callithrix jacchus	62.65	1.00e-45	177.00
IUUC-Cfa-021041	Canis familiaris	40.71	8.00e-74	271.00
IUUC-Cre-022788	Chlamydomonas reinhardtii	24.74	4.00e-08	52.80
IUUC-Csa-024133	Chlorocebus sabaeus	59.88	1.00e-43	171.00
IUUC-Cho-024624	Choloepus hoffmanni	33.57	2.00e-31	130.00
IUUC-Dno-029774	Dasypus novemcinctus	43.01	5.00e-74	271.00
IUUC-Dor-030190	Dipodomys ordii	51.14	2.00e-24	107.00
IUUC-Eca-033607	Equus caballus	51.77	5.00e-36	145.00
IUUC-Eeu-034888	Erinaceus europaeus	57.50	1.00e-49	190.00
IUUC-Fca-036075	Felis catus	42.70	1.00e-76	280.00
IUUC-Fal-037569	Ficedula albicollis	41.91	7.00e-69	254.00
IUUC-Gmo-038588	Gadus morhua	46.54	1.00e-93	336.00
IUUC-Gga-040777	Gallus gallus	42.44	2.00e-75	276.00
IUUC-Gac-042463	Gasterosteus aculeatus	52.17	5.00e-94	338.00
IUUC-Ggo-045269	Gorilla gorilla	51.98	1.00e-43	171.00
IUUC-Hsa-046249	Homo sapiens	41.06	2.00e-66	246.00
IUUC-Itr-048314	Ictidomys tridecemlineatus	42.09	5.00e-74	271.00
IUUC-Lch-049805	Latimeria chalumnae	44.77	3.00e-85	309.00
IUUC-Loc-052377	Lepisosteus oculatus	54.08	5.00e-113	401.00
IUUC-Mcc-055344	Macaca mulatta	59.88	1.00e-43	171.00
IUUC-Meu-055950	Macropus eugenii	40.89	2.00e-61	229.00
IUUC-Mga-060049	Meleagris gallopavo	50.00	3.00e-48	186.00
IUUC-Mmr-061431	Microcebus murinus	42.92	4.00e-71	262.00
IUUC-Mdo-062016	Monodelphis domestica	61.94	1.00e-39	159.00
IUUC-Mmu-063235	Mus musculus	58.08	8.00e-52	197.00
IUUC-Mpu-066449	Mustela putorius furo	41.13	3.00e-74	272.00
IUUC-Mlu-067588	Myotis lucifugus	42.25	5.00e-66	245.00
IUUC-Nfi-068546	Neosartorya fischeri	57.14	2.00e-06	48.50
IUUC-Nle-069192	Nomascus leucogenys	59.88	1.00e-43	171.00
IUUC-Opr-070300	Ochotona princeps	55.21	1.00e-28	121.00
IUUC-Ont-071998	Oreochromis niloticus	53.56	5.00e-99	355.00
IUUC-Oan-073610	Ornithorhynchus anatinus	56.55	4.00e-48	184.00
IUUC-Ocu-074603	Oryctolagus cuniculus	61.84	4.00e-43	169.00
IUUC-Ola-086681	Oryzias latipes	49.58	5.00e-105	375.00
IUUC-Oga-088183	Otolemur garnettii	42.53	4.00e-75	275.00
IUUC-Oar-090255	Ovis aries	62.68	3.00e-39	156.00
IUUC-Ptr-091029	Pan troglodytes	59.88	7.00e-44	171.00
IUUC-Pan-092241	Papio anubis	59.88	9.00e-44	171.00
IUUC-Psi-093506	Pelodiscus sinensis	41.25	5.00e-73	268.00
IUUC-Pma-094579	Petromyzon marinus	54.44	3.00e-25	109.00
IUUC-Pfo-097014	Poecilia formosa	54.80	2.00e-102	366.00
IUUC-Pab-098530	Pongo abelii	59.88	1.00e-43	171.00
IUUC-Pca-100939	Procavia capensis	33.61	3.00e-47	182.00
IUUC-Pva-103148	Pteropus vampyrus	39.03	2.00e-61	229.00
IUUC-Rno-105338	Rattus norvegicus	41.41	1.00e-82	300.00
IUUC-Sha-107187	Sarcophilus harrisii	62.87	3.00e-49	189.00
IUUC-Sar-113356	Sorex araneus	59.87	2.00e-40	159.00
IUUC-Ssc-116290	Sus scrofa	42.56	6.00e-78	285.00
IUUC-Tru-117910	Takifugu rubripes	50.64	8.00e-94	337.00
IUUC-Tsy-119329	Tarsius syrichta	51.15	1.00e-39	157.00
IUUC-Tni-120521	Tetraodon nigroviridis	50.85	5.00e-95	341.00
IUUC-Ttr-128997	Tursiops truncatus	44.31	4.00e-36	145.00
IUUC-Vpa-130154	Vicugna pacos	37.68	4.00e-66	245.00
IUUC-Xtr-132805	Xenopus tropicalis	48.70	5.00e-27	115.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence