iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000000708.14	ENSMUST00000000724.14	ENSMUSP00000000724.8
ENSMUSG00000000708.14	ENSMUST00000164390.1	ENSMUSP00000127659.1
ENSMUSG00000000708.14	ENSMUST00000166525.1	ENSMUSP00000126232.1
ENSMUSG00000000708.14	ENSMUST00000171072.1	ENSMUSP00000127807.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	94.33	0.00e+00	1398.00	IUUC-Hsa-046970

Active Site

Position(s)	Description	Evidence
551	Proton donor/acceptor	{ECO:0000250\|UniProtKB:Q92830}

Organism

Mus musculus

Functional Description
(View)

Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (By similarity).

Protein Sequence
(Fasta)

MAEAGGAGSP ALPPAPPHGS PRTLATAAGS SASCGPATAV AAAGTAEGPG GGGSARIAVK 60
KAQLRSAPRA KKLEKLGVYS ACKAEESCKC NGWKNPNPSP TPPRGDLQQI IVSLTESCRS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCACGCCAT GATTTTGGTG AATTAGCAAC AAAGAGGAGG ATTGGCCGCT GACGGGTACT 60
TCTGGAAAAC ATTTTTTTTT CCTCTGGCTC CCGCTAGGGT GGAGGAAGTT GGGTCTCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0012--Acyltransferase
KW-0090--Biological rhythms
KW-0103--Bromodomain
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase

Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR016376--GCN5/PCAF
IPR000182--GNAT_dom
IPR009464--PCAF_N

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51186--GNAT

Pfam

PF00583--Acetyltransf_1
PF00439--Bromodomain
PF06466--PCAF_N

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO

Gene Ontology

GO:0031672--C:A band
GO:0042641--C:actomyosin
GO:0005671--C:Ada2/Gcn5/Ada3 transcription activator complex
GO:0000123--C:histone acetyltransferase complex
GO:0031674--C:I band
GO:0000776--C:kinetochore
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016407--F:acetyltransferase activity
GO:0003682--F:chromatin binding
GO:0004861--F:cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0004402--F:histone acetyltransferase activity
GO:0042826--F:histone deacetylase binding
GO:0004468--F:lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
GO:0032403--F:protein complex binding
GO:0019901--F:protein kinase binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003713--F:transcription coactivator activity
GO:0003712--F:transcription cofactor activity
GO:0008134--F:transcription factor binding
GO:0007049--P:cell cycle
GO:0032869--P:cellular response to insulin stimulus
GO:0006338--P:chromatin remodeling
GO:0016573--P:histone acetylation
GO:0043966--P:histone H3 acetylation
GO:0043970--P:histone H3-K9 acetylation
GO:0018393--P:internal peptidyl-lysine acetylation
GO:0018076--P:N-terminal peptidyl-lysine acetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0007219--P:Notch signaling pathway
GO:0018394--P:peptidyl-lysine acetylation
GO:0035948--P:positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006473--P:protein acetylation
GO:0010835--P:regulation of protein ADP-ribosylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0048511--P:rhythmic process
GO:0006361--P:transcription initiation from RNA polymerase I promoter

KEGG

mmu:18519

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001599	Ailuropoda melanoleuca	93.37	0.00e+00	1337.00
IUUC-Atr-003130	Amborella trichopoda	40.89	2.00e-86	313.00
IUUC-Apl-004026	Anas platyrhynchos	88.80	0.00e+00	1259.00
IUUC-Aly-006486	Arabidopsis lyrata	42.93	4.00e-76	279.00
IUUC-Ath-006763	Arabidopsis thaliana	43.36	1.00e-76	280.00
IUUC-Ago-007819	Ashbya gossypii	48.16	1.00e-86	313.00
IUUC-Acl-008194	Aspergillus clavatus	44.60	4.00e-80	291.00
IUUC-Afl-008546	Aspergillus flavus	44.32	2.00e-80	293.00
IUUC-Afu-009124	Aspergillus fumigatus	45.17	1.00e-81	296.00
IUUC-Ani-009432	Aspergillus nidulans	43.08	3.00e-75	275.00
IUUC-Ang-009824	Aspergillus niger	45.27	5.00e-81	295.00
IUUC-Aor-010076	Aspergillus oryzae	43.45	2.00e-78	285.00
IUUC-Bgr-012003	Blumeria graminis	40.52	3.00e-73	268.00
IUUC-Bta-012381	Bos taurus	92.07	0.00e+00	1365.00
IUUC-Bci-013974	Botrytis cinerea	44.93	4.00e-81	295.00
IUUC-Bdi-015016	Brachypodium distachyon	42.97	2.00e-84	306.00
IUUC-Cel-018633	Caenorhabditis elegans	47.80	2.00e-85	310.00
IUUC-Cja-019375	Callithrix jacchus	93.36	0.00e+00	1298.00
IUUC-Cfa-020400	Canis familiaris	88.92	0.00e+00	1240.00
IUUC-Cpo-021686	Cavia porcellus	94.53	0.00e+00	1379.00
IUUC-Cre-023019	Chlamydomonas reinhardtii	54.35	2.00e-52	199.00
IUUC-Csa-024252	Chlorocebus sabaeus	94.07	0.00e+00	1261.00
IUUC-Cho-024635	Choloepus hoffmanni	90.75	0.00e+00	949.00
IUUC-Cgl-026660	Colletotrichum gloeosporioides	43.55	6.00e-74	271.00
IUUC-Cne-027050	Cryptococcus neoformans	43.94	9.00e-72	265.00
IUUC-Dre-027468	Danio rerio	81.46	0.00e+00	1201.00
IUUC-Dno-029306	Dasypus novemcinctus	85.77	0.00e+00	1206.00
IUUC-Dor-030465	Dipodomys ordii	85.14	0.00e+00	636.00
IUUC-Dse-031386	Dothistroma septosporum	39.84	6.00e-70	258.00
IUUC-Eca-034212	Equus caballus	94.94	0.00e+00	1349.00
IUUC-Eeu-034605	Erinaceus europaeus	66.73	0.00e+00	680.00
IUUC-Fca-035972	Felis catus	94.37	0.00e+00	1264.00
IUUC-Fal-037223	Ficedula albicollis	88.80	0.00e+00	1274.00
IUUC-Fox-037874	Fusarium oxysporum	42.69	2.00e-74	273.00
IUUC-Fso-038286	Fusarium solani	43.27	7.00e-75	274.00
IUUC-Gmo-039102	Gadus morhua	79.50	0.00e+00	1177.00
IUUC-Ggr-039925	Gaeumannomyces graminis	45.53	3.00e-79	289.00
IUUC-Gga-041181	Gallus gallus	88.70	0.00e+00	1323.00
IUUC-Gac-041887	Gasterosteus aculeatus	79.22	0.00e+00	1175.00
IUUC-Gma-043540	Glycine max	43.16	5.00e-87	315.00
IUUC-Ggo-044607	Gorilla gorilla	94.33	0.00e+00	1430.00
IUUC-Hsa-046970	Homo sapiens	94.33	0.00e+00	1430.00
IUUC-Hvu-047105	Hordeum vulgare	47.00	5.00e-52	198.00
IUUC-Kpa-049146	Komagataella pastoris	44.69	3.00e-84	305.00
IUUC-Lch-049478	Latimeria chalumnae	84.85	0.00e+00	1288.00
IUUC-Lpe-051678	Leersia perrieri	44.86	4.00e-78	285.00
IUUC-Loc-052255	Lepisosteus oculatus	84.15	0.00e+00	1283.00
IUUC-Laf-054575	Loxodonta africana	93.60	0.00e+00	1363.00
IUUC-Mcc-055161	Macaca mulatta	93.91	0.00e+00	1380.00
IUUC-Mor-057026	Magnaporthe oryzae	44.10	1.00e-79	290.00
IUUC-Mpo-057590	Magnaporthe poae	44.99	4.00e-80	291.00
IUUC-Mtr-057835	Medicago truncatula	45.92	2.00e-81	296.00
IUUC-Mla-058950	Melampsora laricipopulina	44.70	8.00e-76	277.00
IUUC-Mvi-060295	Microbotryum violaceum	45.86	3.00e-77	283.00
IUUC-Mmr-060643	Microcebus murinus	91.73	0.00e+00	1361.00
IUUC-Mdo-062732	Monodelphis domestica	90.93	0.00e+00	1354.00
IUUC-Mpu-066371	Mustela putorius furo	94.67	0.00e+00	1266.00
IUUC-Mlu-067447	Myotis lucifugus	92.34	0.00e+00	1316.00
IUUC-Nfi-068373	Neosartorya fischeri	45.17	3.00e-82	298.00
IUUC-Ncr-068652	Neurospora crassa	42.90	1.00e-74	273.00
IUUC-Nle-069659	Nomascus leucogenys	94.33	0.00e+00	1428.00
IUUC-Ont-071244	Oreochromis niloticus	81.29	0.00e+00	1190.00
IUUC-Oan-072794	Ornithorhynchus anatinus	90.38	0.00e+00	1209.00
IUUC-Ocu-074701	Oryctolagus cuniculus	92.64	0.00e+00	1301.00
IUUC-Oba-075479	Oryza barthii	43.36	1.00e-57	217.00
IUUC-Ogl-076970	Oryza glaberrima	44.15	3.00e-81	295.00
IUUC-Oin-079610	Oryza indica	43.36	2.00e-57	217.00
IUUC-Oni-083016	Oryza nivara	43.83	7.00e-80	291.00
IUUC-Opu-083976	Oryza punctata	45.09	3.00e-80	292.00
IUUC-Osa-085814	Oryza sativa	44.15	3.00e-81	295.00
IUUC-Ola-087071	Oryzias latipes	80.90	0.00e+00	1186.00
IUUC-Olu-087711	Ostreococcus lucimarinus	41.21	8.00e-76	277.00
IUUC-Oga-089043	Otolemur garnettii	94.73	0.00e+00	1401.00
IUUC-Oar-089893	Ovis aries	87.90	0.00e+00	1259.00
IUUC-Ptr-090629	Pan troglodytes	94.20	0.00e+00	1427.00
IUUC-Pan-092305	Papio anubis	94.35	0.00e+00	1427.00
IUUC-Psi-093574	Pelodiscus sinensis	85.95	0.00e+00	1244.00
IUUC-Pma-094160	Petromyzon marinus	75.79	0.00e+00	1113.00
IUUC-Ppa-095410	Physcomitrella patens	43.13	2.00e-78	286.00
IUUC-Pfo-097043	Poecilia formosa	81.27	0.00e+00	1181.00
IUUC-Pab-098748	Pongo abelii	95.57	0.00e+00	749.00
IUUC-Pca-100223	Procavia capensis	92.49	0.00e+00	1347.00
IUUC-Ppe-101832	Prunus persica	45.08	2.00e-87	316.00
IUUC-Pva-102122	Pteropus vampyrus	94.86	0.00e+00	1402.00
IUUC-Pte-104228	Pyrenophora teres	44.57	1.00e-82	300.00
IUUC-Pyt-104702	Pyrenophora triticirepentis	39.64	3.00e-83	301.00
IUUC-Sce-106432	Saccharomyces cerevisiae	46.72	1.00e-83	303.00
IUUC-Sha-107338	Sarcophilus harrisii	90.21	0.00e+00	1199.00
IUUC-Spo-108273	Schizosaccharomyces pombe	48.45	1.00e-94	340.00
IUUC-Ssl-108545	Sclerotinia sclerotiorum	45.01	2.00e-77	282.00
IUUC-Smo-109385	Selaginella moellendorffii	42.78	2.00e-78	286.00
IUUC-Sit-110222	Setaria italica	44.15	5.00e-81	295.00
IUUC-Sly-111498	Solanum lycopersicum	48.36	7.00e-54	204.00
IUUC-Sar-113574	Sorex araneus	94.80	0.00e+00	1349.00
IUUC-Sbi-114471	Sorghum bicolor	44.68	1.00e-82	300.00
IUUC-Sre-114915	Sporisorium reilianum	42.36	4.00e-82	299.00
IUUC-Ssc-116097	Sus scrofa	93.79	0.00e+00	1250.00
IUUC-Tgu-116699	Taeniopygia guttata	88.93	0.00e+00	1258.00
IUUC-Tru-118001	Takifugu rubripes	79.95	0.00e+00	1180.00
IUUC-Tsy-118910	Tarsius syrichta	77.92	0.00e+00	800.00
IUUC-Tni-119684	Tetraodon nigroviridis	80.55	0.00e+00	1184.00
IUUC-Tca-121066	Theobroma cacao	42.70	2.00e-84	306.00
IUUC-Tre-122112	Trichoderma reesei	43.27	8.00e-77	280.00
IUUC-Tvi-122355	Trichoderma virens	43.27	2.00e-76	279.00
IUUC-Tae-123931	Triticum aestivum	42.71	1.00e-77	284.00
IUUC-Tur-126587	Triticum urartu	42.78	1.00e-77	283.00
IUUC-Tme-126963	Tuber melanosporum	45.11	5.00e-84	304.00
IUUC-Tbe-127304	Tupaia belangeri	80.57	0.00e+00	1130.00
IUUC-Ttr-128536	Tursiops truncatus	94.25	0.00e+00	1342.00
IUUC-Uma-129538	Ustilago maydis	42.09	4.00e-81	295.00
IUUC-Vda-129860	Verticillium dahliae	44.00	4.00e-80	291.00
IUUC-Vpa-130239	Vicugna pacos	75.37	1.00e-155	543.00
IUUC-Vvi-130897	Vitis vinifera	43.75	1.00e-88	320.00
IUUC-Xtr-132300	Xenopus tropicalis	85.39	0.00e+00	1246.00
IUUC-Xma-134105	Xiphophorus maculatus	78.68	0.00e+00	1171.00
IUUC-Yli-134345	Yarrowia lipolytica	48.28	8.00e-87	314.00
IUUC-Zma-135384	Zea mays	43.62	8.00e-80	291.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence