iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071720

Ensembl Protein ID

ENSONIP00000012898.1

UniProt Accession

I3JVK3; I3JVK3_ORENI

Genbank Protein ID

ENSONIP00000012898

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01006540

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000010256.1	ENSONIT00000012908.1	ENSONIP00000012898.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.80e-100	337.0	723	1046

Active Site

Position(s)	Description	Evidence
1015	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgEe++d+gGv +ef+ l++kel +p++g+f+y e+++  ++ n++      e ++lF+++G+++g+a+++  +++l
   Q: 723  DYKKPLKVIFVGEEAVDAGGVRKEFFLLIMKELLDPKYGMFRYYEESRLIWFSNKTF-----EDIDLFNLIGVICGLAIYNLTIVEL 804
           78999***********************************************99977.....69*********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+kk +ledl+e++p++ +sl++++++ e+d+ee+ ++l+f+++ee++g t++ eL+p+Geni+V+++N++++v+++
   Q: 805  NFPLALYKKLLKKKPTLEDLKELMPDVGRSLQQLLDYTEDDLEET-FCLNFTITEENYGATEVFELVPNGENINVNMSNRQDFVNAY 890
           *************************************99999987.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y ++++++  +e f++Gf++v+  ++l+lF+++el+ ++ G++++d+ +l+k+t+ykg+y  d+p+i+ Fwev++++  e++k+f
   Q: 891  VDYVFNTSVAPLFECFYAGFHKVCGGKVLELFQPNELQAMVIGNTNYDWMELEKTTEYKGEYWTDHPTIRLFWEVFHDLPLEKKKQF 977
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++lk    vi+   + ++ lP ++TCfn+L+LP+Y+s e l+ekLl Ai++++gF+l
   Q: 978  LLFLTGSDRIPILGMKSLK---LVIQPtGGGEHYLPVAHTCFNLLDLPKYTSLEMLREKLLQAIDHNQGFNL 1046
           *******************...6666658889**************************************87 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MLCWGNASYG QLGLGGIDEE IVVEPRKCEF FHGKQVSDVG CGRRHTAFLL EDGTVYTCGC 60
NDLGQLGHEK ARKKPEQVVA LDAQIIVAVS CGEAHTLALN DKGQVFSWGL GSDGQLGLNN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTAAGATTT GCTCTTGGCG CTAACATAAG AGACACCTGG CTGTAAGTTG TTCAACTTAT 60
GCTTTAAGTG GAACAGTAAA GAATGGCGGG GCTTTAAGTT GAGATACTCA GCTGTGAAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	74.81	0.00e+00	1546.00
IUUC-Apl-003295	Anas platyrhynchos	73.91	0.00e+00	1553.00
IUUC-Aca-004336	Anolis carolinensis	74.05	0.00e+00	1559.00
IUUC-Ame-010768	Astyanax mexicanus	78.88	0.00e+00	1661.00
IUUC-Bta-013279	Bos taurus	74.91	0.00e+00	1543.00
IUUC-Cel-018150	Caenorhabditis elegans	34.97	7.00e-151	528.00
IUUC-Cja-019023	Callithrix jacchus	74.81	0.00e+00	1544.00
IUUC-Cfa-021074	Canis familiaris	74.91	0.00e+00	1546.00
IUUC-Cpo-021461	Cavia porcellus	73.35	0.00e+00	1506.00
IUUC-Csa-024261	Chlorocebus sabaeus	74.91	0.00e+00	1545.00
IUUC-Cho-024513	Choloepus hoffmanni	57.14	0.00e+00	648.00
IUUC-Cin-025232	Ciona intestinalis	43.87	0.00e+00	823.00
IUUC-Dre-028829	Danio rerio	80.42	0.00e+00	1670.00
IUUC-Dno-029445	Dasypus novemcinctus	71.67	0.00e+00	1223.00
IUUC-Dor-030158	Dipodomys ordii	78.63	0.00e+00	718.00
IUUC-Dme-032103	Drosophila melanogaster	44.56	0.00e+00	880.00
IUUC-Ete-033072	Echinops telfairi	67.27	0.00e+00	1344.00
IUUC-Eca-033317	Equus caballus	74.43	0.00e+00	1541.00
IUUC-Fca-035682	Felis catus	75.38	0.00e+00	1551.00
IUUC-Fal-036969	Ficedula albicollis	73.04	0.00e+00	1538.00
IUUC-Gmo-038671	Gadus morhua	83.11	0.00e+00	1757.00
IUUC-Gga-041174	Gallus gallus	73.51	0.00e+00	1551.00
IUUC-Gac-042600	Gasterosteus aculeatus	89.61	0.00e+00	1831.00
IUUC-Ggo-044589	Gorilla gorilla	74.72	0.00e+00	1564.00
IUUC-Hsa-046772	Homo sapiens	74.62	0.00e+00	1560.00
IUUC-Lch-050147	Latimeria chalumnae	73.46	0.00e+00	1295.00
IUUC-Lpe-051165	Leersia perrieri	35.80	1.00e-48	187.00
IUUC-Loc-052684	Lepisosteus oculatus	79.45	0.00e+00	1662.00
IUUC-Laf-053844	Loxodonta africana	74.15	0.00e+00	1536.00
IUUC-Mcc-055531	Macaca mulatta	73.15	0.00e+00	1529.00
IUUC-Mga-060151	Meleagris gallopavo	71.64	0.00e+00	1256.00
IUUC-Mmr-060954	Microcebus murinus	74.91	0.00e+00	1548.00
IUUC-Mdo-062246	Monodelphis domestica	73.69	0.00e+00	1423.00
IUUC-Mmu-063369	Mus musculus	75.00	0.00e+00	1558.00
IUUC-Mpu-065936	Mustela putorius furo	74.21	0.00e+00	1413.00
IUUC-Mlu-067326	Myotis lucifugus	74.43	0.00e+00	1509.00
IUUC-Nle-069453	Nomascus leucogenys	75.38	0.00e+00	1550.00
IUUC-Oan-073464	Ornithorhynchus anatinus	74.41	0.00e+00	1435.00
IUUC-Ocu-074207	Oryctolagus cuniculus	72.30	0.00e+00	1399.00
IUUC-Ola-086762	Oryzias latipes	86.67	0.00e+00	1775.00
IUUC-Oga-088435	Otolemur garnettii	75.19	0.00e+00	1550.00
IUUC-Oar-089233	Ovis aries	74.81	0.00e+00	1542.00
IUUC-Ptr-091368	Pan troglodytes	74.72	0.00e+00	1561.00
IUUC-Pan-092300	Papio anubis	74.91	0.00e+00	1545.00
IUUC-Psi-093406	Pelodiscus sinensis	74.36	0.00e+00	1566.00
IUUC-Pma-094113	Petromyzon marinus	67.35	0.00e+00	1058.00
IUUC-Ppa-095354	Physcomitrella patens	33.55	5.00e-149	522.00
IUUC-Pfo-097021	Poecilia formosa	85.29	0.00e+00	1847.00
IUUC-Pab-098327	Pongo abelii	74.81	0.00e+00	1562.00
IUUC-Pva-102909	Pteropus vampyrus	66.57	0.00e+00	1287.00
IUUC-Rno-105457	Rattus norvegicus	74.72	0.00e+00	1554.00
IUUC-Sha-106632	Sarcophilus harrisii	74.33	0.00e+00	1564.00
IUUC-Sar-113679	Sorex araneus	64.30	0.00e+00	829.00
IUUC-Tgu-116849	Taeniopygia guttata	70.10	0.00e+00	1450.00
IUUC-Tru-118206	Takifugu rubripes	84.37	0.00e+00	1714.00
IUUC-Tsy-119521	Tarsius syrichta	62.78	0.00e+00	1212.00
IUUC-Tni-120233	Tetraodon nigroviridis	83.81	0.00e+00	1698.00
IUUC-Tbe-127941	Tupaia belangeri	61.55	0.00e+00	1042.00
IUUC-Vpa-130448	Vicugna pacos	74.72	0.00e+00	1542.00
IUUC-Xtr-132719	Xenopus tropicalis	65.28	0.00e+00	1259.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence