iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mlu-067601

Ensembl Protein ID

ENSMLUP00000013814.2

UniProt Accession

G1PRN8; G1PRN8_MYOLU

Genbank Protein ID

ENSMLUP00000013814

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02052884

Gene Name

NOD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000015152.2	ENSMLUT00000015164.2	ENSMLUP00000013814.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	2.80e-14	53.5	140	192

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 3    eeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaa 55
           +e+rl+++t ++r+r+lLd+++v++++l++fll++++el+++ a   +++++ 
   Q: 140  DEIRLPIFTSSQRARRLLDLATVKANGLAAFLLQHVQELPVPLALSLEDAACR 192
           8*********************************************9999996 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

CTQQAFQAQR SQLVGLLGSG SLEAFESVLD WLLSWDVLSW EEYEGLHVLG QSLSHSARRL 60
LDTVWNKGAW GCEQLLAAVQ EAQADGRSPE LHGHWDPHSP HPARDLQCHR PAIVRRLYSH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCACGCAGC AAGCTTTCCA AGCCCAGAGG AGCCAGCTGG TGGGGCTGCT GGGCTCGGGG 60
TCCCTGGAGG CCTTCGAGAG CGTCCTGGAC TGGCTGCTCT CCTGGGACGT GCTGTCCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome

Interpro

IPR007109--Brix
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase

PROSITE

PS50209--CARD
PS50837--NACHT

Pfam

PF00619--CARD
PF13516--LRR_6

Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0008180--C:COP9 signalosome
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0031982--C:vesicle
GO:0005524--F:ATP binding
GO:0032500--F:muramyl dipeptide binding
GO:0042834--F:peptidoglycan binding
GO:0071225--P:cellular response to muramyl dipeptide
GO:0002374--P:cytokine secretion involved in immune response
GO:0042742--P:defense response to bacterium
GO:0016045--P:detection of bacterium
GO:0032498--P:detection of muramyl dipeptide
GO:0045087--P:innate immune response
GO:0030277--P:maintenance of gastrointestinal epithelium
GO:0070431--P:nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0050871--P:positive regulation of B cell activation
GO:1900017--P:positive regulation of cytokine production involved in inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0032740--P:positive regulation of interleukin-17 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0002830--P:positive regulation of type 2 immune response
GO:0042981--P:regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001822	Ailuropoda melanoleuca	79.45	0.00e+00	1398.00
IUUC-Ame-011021	Astyanax mexicanus	45.84	0.00e+00	867.00
IUUC-Bta-013241	Bos taurus	79.74	0.00e+00	1549.00
IUUC-Cja-019633	Callithrix jacchus	77.96	0.00e+00	1147.00
IUUC-Cfa-020039	Canis familiaris	80.43	0.00e+00	1545.00
IUUC-Cpo-022337	Cavia porcellus	76.38	0.00e+00	1446.00
IUUC-Csa-023906	Chlorocebus sabaeus	81.03	0.00e+00	1556.00
IUUC-Dre-027568	Danio rerio	45.82	0.00e+00	822.00
IUUC-Dno-029098	Dasypus novemcinctus	78.58	0.00e+00	1405.00
IUUC-Dor-031102	Dipodomys ordii	70.66	0.00e+00	637.00
IUUC-Ete-032943	Echinops telfairi	74.42	0.00e+00	1051.00
IUUC-Eca-034310	Equus caballus	83.60	0.00e+00	1554.00
IUUC-Eeu-034589	Erinaceus europaeus	81.98	2.00e-158	553.00
IUUC-Fca-036252	Felis catus	80.67	0.00e+00	778.00
IUUC-Gac-041442	Gasterosteus aculeatus	45.35	0.00e+00	808.00
IUUC-Ggo-044861	Gorilla gorilla	81.32	0.00e+00	1513.00
IUUC-Hsa-046093	Homo sapiens	80.73	0.00e+00	1500.00
IUUC-Itr-048543	Ictidomys tridecemlineatus	77.98	0.00e+00	1394.00
IUUC-Lch-049454	Latimeria chalumnae	52.33	0.00e+00	913.00
IUUC-Laf-053553	Loxodonta africana	80.83	0.00e+00	1430.00
IUUC-Mcc-055772	Macaca mulatta	81.13	0.00e+00	1533.00
IUUC-Meu-056785	Macropus eugenii	68.63	5.00e-111	395.00
IUUC-Mmr-060596	Microcebus murinus	81.13	0.00e+00	1501.00
IUUC-Mdo-062983	Monodelphis domestica	65.81	0.00e+00	1072.00
IUUC-Mmu-063951	Mus musculus	73.69	0.00e+00	1427.00
IUUC-Mpu-066412	Mustela putorius furo	79.94	0.00e+00	1534.00
IUUC-Nle-069913	Nomascus leucogenys	81.11	0.00e+00	1266.00
IUUC-Opr-070999	Ochotona princeps	78.19	0.00e+00	889.00
IUUC-Ont-072512	Oreochromis niloticus	45.78	0.00e+00	857.00
IUUC-Oan-073564	Ornithorhynchus anatinus	61.92	0.00e+00	1093.00
IUUC-Ocu-074837	Oryctolagus cuniculus	80.04	0.00e+00	1489.00
IUUC-Ola-086555	Oryzias latipes	44.60	0.00e+00	804.00
IUUC-Oga-088909	Otolemur garnettii	79.55	0.00e+00	1487.00
IUUC-Oar-089315	Ovis aries	79.07	0.00e+00	1504.00
IUUC-Ptr-090542	Pan troglodytes	81.13	0.00e+00	1509.00
IUUC-Pan-092545	Papio anubis	81.23	0.00e+00	1533.00
IUUC-Pma-094167	Petromyzon marinus	35.28	1.00e-65	244.00
IUUC-Ppa-095344	Physcomitrella patens	25.50	6.00e-07	49.70
IUUC-Pfo-096976	Poecilia formosa	43.25	0.00e+00	811.00
IUUC-Pab-098481	Pongo abelii	80.73	0.00e+00	1495.00
IUUC-Pca-100135	Procavia capensis	74.01	0.00e+00	1253.00
IUUC-Pva-102127	Pteropus vampyrus	81.13	0.00e+00	1389.00
IUUC-Rno-105783	Rattus norvegicus	75.83	0.00e+00	1428.00
IUUC-Sce-106163	Saccharomyces cerevisiae	26.88	2.40e-01	32.00
IUUC-Sar-113448	Sorex araneus	74.11	0.00e+00	886.00
IUUC-Tru-118708	Takifugu rubripes	43.71	0.00e+00	759.00
IUUC-Tni-120172	Tetraodon nigroviridis	35.45	9.00e-31	127.00
IUUC-Tbe-127661	Tupaia belangeri	80.53	0.00e+00	785.00
IUUC-Ttr-128318	Tursiops truncatus	75.47	0.00e+00	1338.00
IUUC-Vpa-130502	Vicugna pacos	71.09	3.00e-144	506.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence