iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033605

Ensembl Protein ID

ENSECAP00000020237.1

UniProt Accession

F6UQ47; F6UQ47_HORSE

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Gene Name

ESR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000022441.1	ENSECAT00000024250.1	ENSECAP00000020141.1
ENSECAG00000022441.1	ENSECAT00000024366.1	ENSECAP00000020237.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	87.39	0.00e+00	959.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Equus caballus

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

MTMTLHTKAS GMALLHQIQG NELETLNLPQ FKIPLERPLG EVYVESSKPP VYDYPEVAAY 60
DFNAAAAASA SVYGQSGLAY GPGSEAAAFG ANGLGFPPLN SVSPSQLMLL QPPSQFSPYL 120

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Nucleotide Sequence
(Fasta)

GCTCGCAGGG CTGCACTTGC TCGCGTCTGG CCGCCCAGTG CCACGGGACG GCCGGCTCCG 60
GGGCAGGGCC AGAGCTGGTG TCGCGGCAGG ACATGCGCTG CGCCGCCTCT AACCGCGGGC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00543--OESTROGENR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005886--C:plasma membrane
GO:0035327--C:transcriptionally active chromatin
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0034056--F:estrogen response element binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0038052--F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0008209--P:androgen metabolic process
GO:0001547--P:antral ovarian follicle growth
GO:0071392--P:cellular response to estradiol stimulus
GO:0071391--P:cellular response to estrogen stimulus
GO:0002064--P:epithelial cell development
GO:0060750--P:epithelial cell proliferation involved in mammary gland duct elongation
GO:0008584--P:male gonad development
GO:0060749--P:mammary gland alveolus development
GO:0060745--P:mammary gland branching involved in pregnancy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0071168--P:protein localization to chromatin
GO:0042981--P:regulation of apoptotic process
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0050727--P:regulation of inflammatory response
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0060065--P:uterus development
GO:0060068--P:vagina development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	91.31	0.00e+00	787.00
IUUC-Apl-003688	Anas platyrhynchos	75.46	0.00e+00	742.00
IUUC-Aca-005222	Anolis carolinensis	73.39	0.00e+00	805.00
IUUC-Ame-010731	Astyanax mexicanus	56.68	3.00e-131	462.00
IUUC-Bta-013112	Bos taurus	84.73	0.00e+00	905.00
IUUC-Cja-019408	Callithrix jacchus	88.24	0.00e+00	952.00
IUUC-Cfa-020694	Canis familiaris	84.73	0.00e+00	901.00
IUUC-Cpo-021426	Cavia porcellus	81.04	0.00e+00	858.00
IUUC-Cre-022648	Chlamydomonas reinhardtii	30.23	2.30e+00	26.60
IUUC-Csa-023736	Chlorocebus sabaeus	88.91	0.00e+00	833.00
IUUC-Dre-027698	Danio rerio	61.76	1.00e-129	456.00
IUUC-Dno-029477	Dasypus novemcinctus	89.08	0.00e+00	748.00
IUUC-Dor-030572	Dipodomys ordii	88.06	0.00e+00	737.00
IUUC-Ete-032849	Echinops telfairi	66.60	6.00e-178	617.00
IUUC-Eeu-034683	Erinaceus europaeus	89.25	7.00e-108	384.00
IUUC-Fca-035928	Felis catus	91.50	0.00e+00	787.00
IUUC-Fal-036754	Ficedula albicollis	74.16	0.00e+00	831.00
IUUC-Gmo-038872	Gadus morhua	56.19	3.00e-112	398.00
IUUC-Gga-040988	Gallus gallus	74.66	0.00e+00	817.00
IUUC-Gac-042015	Gasterosteus aculeatus	60.45	2.00e-126	446.00
IUUC-Ggo-044749	Gorilla gorilla	88.40	0.00e+00	954.00
IUUC-Hsa-046944	Homo sapiens	87.39	0.00e+00	943.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	84.92	0.00e+00	916.00
IUUC-Lch-049855	Latimeria chalumnae	30.09	4.00e-33	135.00
IUUC-Loc-052414	Lepisosteus oculatus	56.68	7.00e-176	610.00
IUUC-Mcc-054781	Macaca mulatta	88.24	0.00e+00	953.00
IUUC-Meu-056232	Macropus eugenii	80.84	0.00e+00	869.00
IUUC-Mga-059319	Meleagris gallopavo	75.17	0.00e+00	822.00
IUUC-Mmr-061636	Microcebus murinus	85.05	1.00e-154	539.00
IUUC-Mdo-062661	Monodelphis domestica	81.85	0.00e+00	884.00
IUUC-Mmu-063330	Mus musculus	84.47	0.00e+00	878.00
IUUC-Mpu-065757	Mustela putorius furo	84.25	0.00e+00	903.00
IUUC-Mlu-067712	Myotis lucifugus	86.34	0.00e+00	813.00
IUUC-Nle-069283	Nomascus leucogenys	87.56	0.00e+00	908.00
IUUC-Opr-070391	Ochotona princeps	84.85	0.00e+00	941.00
IUUC-Ont-071369	Oreochromis niloticus	54.66	2.00e-115	409.00
IUUC-Oan-073734	Ornithorhynchus anatinus	72.30	1.00e-129	455.00
IUUC-Ocu-074292	Oryctolagus cuniculus	85.81	0.00e+00	927.00
IUUC-Oba-075103	Oryza barthii	28.21	6.00e-03	35.40
IUUC-Ogu-079042	Oryza glumaepatula	28.21	1.00e-03	37.70
IUUC-Olo-080944	Oryza longistaminata	28.21	2.00e-03	35.40
IUUC-Oni-082560	Oryza nivara	28.21	5.00e-03	35.80
IUUC-Ola-087052	Oryzias latipes	51.01	4.00e-124	438.00
IUUC-Oga-088586	Otolemur garnettii	87.12	0.00e+00	927.00
IUUC-Oar-090156	Ovis aries	91.26	0.00e+00	824.00
IUUC-Ptr-091321	Pan troglodytes	88.24	0.00e+00	954.00
IUUC-Pan-092851	Papio anubis	88.24	0.00e+00	953.00
IUUC-Psi-093434	Pelodiscus sinensis	74.07	0.00e+00	855.00
IUUC-Pfo-097379	Poecilia formosa	57.30	9.00e-128	450.00
IUUC-Pab-097735	Pongo abelii	88.07	0.00e+00	951.00
IUUC-Pva-102125	Pteropus vampyrus	84.71	0.00e+00	890.00
IUUC-Rno-106121	Rattus norvegicus	84.17	0.00e+00	876.00
IUUC-Sha-107547	Sarcophilus harrisii	82.02	0.00e+00	882.00
IUUC-Sar-113650	Sorex araneus	74.88	9.00e-160	556.00
IUUC-Tgu-117175	Taeniopygia guttata	74.66	0.00e+00	834.00
IUUC-Tru-117545	Takifugu rubripes	52.55	4.00e-134	472.00
IUUC-Tsy-119586	Tarsius syrichta	73.22	0.00e+00	785.00
IUUC-Tni-120121	Tetraodon nigroviridis	54.13	2.00e-133	469.00
IUUC-Tbe-127548	Tupaia belangeri	80.63	0.00e+00	630.00
IUUC-Ttr-128374	Tursiops truncatus	81.34	0.00e+00	828.00
IUUC-Vpa-130464	Vicugna pacos	82.51	6.00e-155	540.00
IUUC-Xtr-132171	Xenopus tropicalis	66.22	0.00e+00	687.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence