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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063310
UUCD1 version UUC-MuM-00398
Ensembl Protein ID ENSMUSP00000080601.7
UniProt Accession Q3UIR3; Q8BN11; DTX3L_MOUSE
Genbank Protein ID BAE27443.1; BAC41115.1; EDK97899.1; AAI37695.1
Protein Name E3 ubiquitin-protein ligase DTX3L; Protein deltex-3-like; RING-type E3 ubiquitin transferase DTX3L
Genbank Nucleotide ID AK146802; AK090152; CH466521; BC137694
Gene Name Dtx3l; Bbap
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000049502.16 ENSMUST00000081933.13 ENSMUSP00000080601.7
ENSMUSG00000049502.16 ENSMUST00000114885.1 ENSMUSP00000110535.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemiRTarBasemicroRNA
TRANSFACRepTarRAID2
Protein-protein Interaction
IIDHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 57.48 0.00e+00 808.00 IUUC-Hsa-045921
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation (By similarity). In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
 Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation (By similarity). In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
Protein Sequence
(Fasta)
MASSPDPPSP LLVRLRESIP KAHRKLEIYF QSRASGGGEC SVQPVGPSAP DTYEVKFLKK 60
ADKEKVLKKS EHEMLVHNKP VTIVLETTKK PVEDLRPRLP SLTQPVETPS SRPPSLTGSL 120
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Protein Fasta Sequence


>IUUC-Mmu-063310|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
AAACTTCCGA TCCTGCAAGA ATAGAAGGGC GACCTGCCAC CGTAGGGAAA CTTCCTCTGA 60
GCGCCCACCG CCGAGCGTGC GAACTACTCA CCGGGTGATG GCTCTGAGAG ATGGCAGAGC 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063310|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0042393--F:histone binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006302--P:double-strand break repair
GO:0010390--P:histone monoubiquitination
KEGG mmu:209200
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001770 Ailuropoda melanoleuca 49.39 0.00e+00 669.00
IUUC-Aca-004465 Anolis carolinensis 36.33 5.00e-108 385.00
IUUC-Ame-011794 Astyanax mexicanus 32.68 1.00e-62 234.00
IUUC-Bta-012460 Bos taurus 51.11 0.00e+00 719.00
IUUC-Cja-019340 Callithrix jacchus 56.50 0.00e+00 819.00
IUUC-Cfa-020691 Canis familiaris 52.02 0.00e+00 741.00
IUUC-Cpo-021781 Cavia porcellus 51.58 0.00e+00 710.00
IUUC-Csa-024106 Chlorocebus sabaeus 58.01 0.00e+00 832.00
IUUC-Cho-024817 Choloepus hoffmanni 53.49 0.00e+00 721.00
IUUC-Csv-025973 Ciona savignyi 50.00 3.00e-47 181.00
IUUC-Dre-028024 Danio rerio 30.39 7.00e-63 235.00
IUUC-Dno-028880 Dasypus novemcinctus 55.02 0.00e+00 763.00
IUUC-Dor-030737 Dipodomys ordii 52.55 0.00e+00 716.00
IUUC-Ete-033015 Echinops telfairi 46.52 2.00e-76 280.00
IUUC-Eca-034086 Equus caballus 54.30 0.00e+00 736.00
IUUC-Eeu-034446 Erinaceus europaeus 52.02 5.00e-174 604.00
IUUC-Fca-036218 Felis catus 53.27 0.00e+00 769.00
IUUC-Fal-036797 Ficedula albicollis 36.68 3.00e-117 416.00
IUUC-Gmo-039104 Gadus morhua 59.14 3.00e-60 224.00
IUUC-Gga-041219 Gallus gallus 35.84 5.00e-109 389.00
IUUC-Ggo-044786 Gorilla gorilla 57.35 0.00e+00 823.00
IUUC-Hsa-045921 Homo sapiens 57.48 0.00e+00 830.00
IUUC-Itr-047911 Ictidomys tridecemlineatus 56.03 0.00e+00 818.00
IUUC-Loc-052602 Lepisosteus oculatus 32.71 1.00e-68 254.00
IUUC-Laf-054092 Loxodonta africana 53.01 0.00e+00 759.00
IUUC-Meu-056309 Macropus eugenii 43.76 7.00e-128 451.00
IUUC-Mga-059221 Meleagris gallopavo 34.89 4.00e-105 375.00
IUUC-Mmr-061722 Microcebus murinus 55.20 0.00e+00 779.00
IUUC-Mdo-062897 Monodelphis domestica 41.88 9.00e-150 524.00
IUUC-Mpu-065715 Mustela putorius furo 50.59 0.00e+00 702.00
IUUC-Mlu-068125 Myotis lucifugus 60.91 1.00e-76 278.00
IUUC-Opr-070573 Ochotona princeps 51.65 0.00e+00 701.00
IUUC-Ont-071501 Oreochromis niloticus 58.20 1.00e-60 225.00
IUUC-Ocu-074404 Oryctolagus cuniculus 52.32 0.00e+00 741.00
IUUC-Ola-087174 Oryzias latipes 54.60 2.00e-51 194.00
IUUC-Oga-088174 Otolemur garnettii 51.58 0.00e+00 656.00
IUUC-Oar-089488 Ovis aries 50.14 0.00e+00 651.00
IUUC-Ptr-091454 Pan troglodytes 57.35 0.00e+00 824.00
IUUC-Pan-092016 Papio anubis 57.87 0.00e+00 826.00
IUUC-Psi-093616 Pelodiscus sinensis 42.97 4.00e-108 385.00
IUUC-Pma-094722 Petromyzon marinus 60.87 1.00e-65 242.00
IUUC-Pfo-097512 Poecilia formosa 50.00 5.00e-60 223.00
IUUC-Pab-098106 Pongo abelii 56.05 0.00e+00 801.00
IUUC-Pva-103155 Pteropus vampyrus 50.57 0.00e+00 635.00
IUUC-Pgr-103282 Puccinia graminis 45.10 4.00e-07 48.10
IUUC-Rno-105277 Rattus norvegicus 76.21 0.00e+00 1119.00
IUUC-Sha-107310 Sarcophilus harrisii 41.54 5.00e-151 528.00
IUUC-Sar-113237 Sorex araneus 50.93 2.00e-118 419.00
IUUC-Ssc-115952 Sus scrofa 53.14 3.00e-150 525.00
IUUC-Tgu-117018 Taeniopygia guttata 37.64 5.00e-110 392.00
IUUC-Tsy-119396 Tarsius syrichta 51.23 6.00e-143 500.00
IUUC-Tbe-127250 Tupaia belangeri 50.73 7.00e-163 567.00
IUUC-Ttr-128283 Tursiops truncatus 49.81 0.00e+00 696.00
Created Date 25-Jun-2017

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