iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000133243.8	ENST00000255608.8	ENSP00000255608.3
ENSG00000133243.8	ENST00000592082.5	ENSP00000481163.1
ENSG00000133243.8	ENST00000587825.1	ENSP00000467113.1
ENSG00000133243.8	ENST00000589200.2	ENSP00000466686.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	dbPTM	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.80e-14	55.5	117	185

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvg....geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv + vg     ++++ah+ vLa  S vF a+f++++  +  + ++e+ dv+p +f allkFlY++++++
   Q: 117  CDVHFLVGkglsSQRIPAHRFVLAVGSAVFDAMFNGGMATT--STEIELPDVEPAAFLALLKFLYSDEVQI 185
           8999999777889**************************87..68**********************9986 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAAGGSGGRA SCPPGVGVGP GTGGSPGPSA NAAATPAPGN AAAAAAAAAA AAAAPGPTPP 60
APPGPGTDAQ AAGAERAEEA AGPGAAALQR EAAYNWQASK PTVQERFAFL FNNEVLCDVH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGGAGGCA AGAGAGATGG CGCTCGGGAC GGAAGGGTTC CCTGCCCTGC CCCAGGAGCC 60
TGCATGGGAG AAGGCGTGAG GAGGTGAAGG AAGCTTATGG TACCTGCACA CCGACAGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR012983--PHR
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF08005--PHR

SMART

SM00875--BACK
SM00225--BTB

Gene Ontology

GO:0005829--C:cytosol
GO:0000932--C:P-body
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0022008--P:neurogenesis
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis

KEGG

hsa:55643

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011722	Astyanax mexicanus	91.53	0.00e+00	841.00
IUUC-Bta-013384	Bos taurus	97.92	0.00e+00	890.00
IUUC-Cel-018446	Caenorhabditis elegans	58.81	9.00e-151	527.00
IUUC-Cja-019900	Callithrix jacchus	97.26	0.00e+00	885.00
IUUC-Cfa-020164	Canis familiaris	88.72	0.00e+00	708.00
IUUC-Cin-025192	Ciona intestinalis	69.68	0.00e+00	648.00
IUUC-Csv-026025	Ciona savignyi	66.97	2.00e-177	615.00
IUUC-Dre-028297	Danio rerio	91.97	0.00e+00	847.00
IUUC-Dor-031079	Dipodomys ordii	92.24	0.00e+00	831.00
IUUC-Eca-033745	Equus caballus	79.59	1.00e-169	588.00
IUUC-Fal-037173	Ficedula albicollis	95.73	0.00e+00	796.00
IUUC-Fso-038326	Fusarium solani	41.43	6.00e-04	38.10
IUUC-Gmo-038536	Gadus morhua	91.36	0.00e+00	838.00
IUUC-Gga-040414	Gallus gallus	94.29	0.00e+00	866.00
IUUC-Gac-042278	Gasterosteus aculeatus	92.20	0.00e+00	846.00
IUUC-Ggo-045295	Gorilla gorilla	100.00	0.00e+00	813.00
IUUC-Itr-048353	Ictidomys tridecemlineatus	98.63	0.00e+00	905.00
IUUC-Lch-050091	Latimeria chalumnae	85.23	0.00e+00	767.00
IUUC-Loc-052280	Lepisosteus oculatus	93.22	0.00e+00	773.00
IUUC-Mmr-060716	Microcebus murinus	99.49	0.00e+00	804.00
IUUC-Mdo-062009	Monodelphis domestica	95.43	0.00e+00	876.00
IUUC-Mmu-064043	Mus musculus	97.72	0.00e+00	893.00
IUUC-Mpu-065960	Mustela putorius furo	97.96	0.00e+00	797.00
IUUC-Mlu-067926	Myotis lucifugus	93.09	0.00e+00	720.00
IUUC-Ont-071481	Oreochromis niloticus	92.20	0.00e+00	846.00
IUUC-Ola-086590	Oryzias latipes	92.20	0.00e+00	848.00
IUUC-Oga-088011	Otolemur garnettii	99.30	0.00e+00	888.00
IUUC-Oar-089514	Ovis aries	98.72	0.00e+00	796.00
IUUC-Pan-092670	Papio anubis	98.25	0.00e+00	811.00
IUUC-Pma-094699	Petromyzon marinus	90.18	0.00e+00	844.00
IUUC-Pfo-097138	Poecilia formosa	92.20	0.00e+00	822.00
IUUC-Sha-106477	Sarcophilus harrisii	96.74	0.00e+00	808.00
IUUC-Sar-113466	Sorex araneus	96.66	0.00e+00	776.00
IUUC-Tgu-116583	Taeniopygia guttata	96.04	0.00e+00	862.00
IUUC-Tru-118211	Takifugu rubripes	92.43	0.00e+00	847.00
IUUC-Tni-120528	Tetraodon nigroviridis	92.43	0.00e+00	847.00
IUUC-Xtr-132426	Xenopus tropicalis	93.38	0.00e+00	857.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence