iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000010919.1	ENSONIT00000013747.1	ENSONIP00000013737.1
ENSONIG00000010919.1	ENSONIT00000013748.1	ENSONIP00000013738.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.60e-132	440.6	556	888

Active Site

Position(s)	Description	Evidence
857	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 556  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 643
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+kk +l+dle++dpe+y+s++++ken   ++ee+g++l f ++ eilg++++++Lk +Gen+ Vt+eNkeeY++l+++
   Q: 644  GFTLPFYKRMLDKKPTLKDLESIDPEFYNSIMWVKEN---NLEECGVELYFAQDMEILGKVSTHQLKDDGENELVTEENKEEYISLLTD 729
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev+ple+l++F+e+elel++cG++eid+ d++k+t y++ yt++s++i+wFw+v++e+++e+r ++LqFv
   Q: 730  WRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDLADWQKNTIYRH-YTKNSKQIHWFWQVVKEMDNEKRIRLLQFV 817
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGf el     p++f+i k +++++lP+s+TCfn+L+LP+Y s e+l+ekLl+Aieet+gF++
   Q: 818  TGTCRLPVGGFSELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYRSLEQLREKLLFAIEETEGFGQ 888
           *********************************************************************96 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MAAASVSRPG SAQTTEKSQL TLKVVSAKPQ SPKLPNRHSR LSSFVEVTAD GLTSETKKTG 60
KRSGHLELQW NEDLTLNVTP QSRLDLKLWS CHTLRKELLG SATIDLLDTL RSHDGKMENV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTGTTTTT CACTGATTGA AGGTGATTTA AGGTAATTGT GTGGGCTGTT TATTATTGTT 60
TTCGACCCAC AATCCTTTGT GCAATGAGAA CGCCATACCC TAGGTCACGT GATACTGTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0060021--P:palate development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	73.30	0.00e+00	1304.00
IUUC-Apl-003912	Anas platyrhynchos	69.00	0.00e+00	1122.00
IUUC-Aca-004291	Anolis carolinensis	72.30	0.00e+00	1300.00
IUUC-Bta-013231	Bos taurus	91.01	0.00e+00	1122.00
IUUC-Cja-019455	Callithrix jacchus	72.94	0.00e+00	1303.00
IUUC-Cfa-021017	Canis familiaris	91.53	0.00e+00	1127.00
IUUC-Cpo-021988	Cavia porcellus	74.35	0.00e+00	1316.00
IUUC-Csa-023549	Chlorocebus sabaeus	72.51	0.00e+00	1312.00
IUUC-Dre-028513	Danio rerio	95.97	0.00e+00	1190.00
IUUC-Dno-028976	Dasypus novemcinctus	71.41	0.00e+00	1313.00
IUUC-Dor-030176	Dipodomys ordii	86.42	0.00e+00	1116.00
IUUC-Eca-033949	Equus caballus	91.01	0.00e+00	1125.00
IUUC-Eeu-034529	Erinaceus europaeus	88.51	0.00e+00	959.00
IUUC-Fca-036236	Felis catus	74.16	0.00e+00	1315.00
IUUC-Fal-036948	Ficedula albicollis	91.96	0.00e+00	1136.00
IUUC-Gmo-038842	Gadus morhua	94.53	0.00e+00	1119.00
IUUC-Gga-040617	Gallus gallus	89.46	0.00e+00	1153.00
IUUC-Gac-041338	Gasterosteus aculeatus	95.73	0.00e+00	1161.00
IUUC-Ggo-045278	Gorilla gorilla	73.05	0.00e+00	1312.00
IUUC-Hsa-046148	Homo sapiens	73.16	0.00e+00	1316.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	90.86	0.00e+00	1046.00
IUUC-Lch-050663	Latimeria chalumnae	75.31	0.00e+00	1368.00
IUUC-Loc-052604	Lepisosteus oculatus	78.80	0.00e+00	1391.00
IUUC-Mcc-055655	Macaca mulatta	72.72	0.00e+00	1312.00
IUUC-Meu-055953	Macropus eugenii	76.79	0.00e+00	969.00
IUUC-Mga-060190	Meleagris gallopavo	89.05	0.00e+00	1157.00
IUUC-Mmr-060896	Microcebus murinus	72.51	0.00e+00	1298.00
IUUC-Mdo-062536	Monodelphis domestica	73.74	0.00e+00	1328.00
IUUC-Mmu-064017	Mus musculus	73.09	0.00e+00	1305.00
IUUC-Mpu-066608	Mustela putorius furo	71.35	0.00e+00	1250.00
IUUC-Mlu-067623	Myotis lucifugus	72.36	0.00e+00	1253.00
IUUC-Nle-069496	Nomascus leucogenys	71.29	0.00e+00	1267.00
IUUC-Opr-071054	Ochotona princeps	90.83	0.00e+00	1112.00
IUUC-Oan-073512	Ornithorhynchus anatinus	68.44	0.00e+00	1211.00
IUUC-Ocu-074271	Oryctolagus cuniculus	72.83	0.00e+00	1286.00
IUUC-Ola-087237	Oryzias latipes	82.02	0.00e+00	1455.00
IUUC-Oga-088164	Otolemur garnettii	72.66	0.00e+00	1305.00
IUUC-Oar-089698	Ovis aries	91.01	0.00e+00	1120.00
IUUC-Ptr-091306	Pan troglodytes	72.17	0.00e+00	1287.00
IUUC-Pan-092814	Papio anubis	69.47	0.00e+00	1237.00
IUUC-Pfo-096709	Poecilia formosa	87.75	0.00e+00	1526.00
IUUC-Pab-098494	Pongo abelii	72.72	0.00e+00	1286.00
IUUC-Pca-100596	Procavia capensis	63.92	0.00e+00	1090.00
IUUC-Pva-103154	Pteropus vampyrus	71.09	0.00e+00	1248.00
IUUC-Rno-104954	Rattus norvegicus	74.77	0.00e+00	1160.00
IUUC-Sha-106781	Sarcophilus harrisii	73.52	0.00e+00	1328.00
IUUC-Ssc-116307	Sus scrofa	84.55	0.00e+00	1058.00
IUUC-Tgu-116530	Taeniopygia guttata	86.07	0.00e+00	1031.00
IUUC-Tru-118287	Takifugu rubripes	81.48	0.00e+00	1441.00
IUUC-Tni-120801	Tetraodon nigroviridis	80.46	0.00e+00	1399.00
IUUC-Tbe-127793	Tupaia belangeri	63.44	0.00e+00	1092.00
IUUC-Ttr-128275	Tursiops truncatus	91.01	0.00e+00	1123.00
IUUC-Xtr-132866	Xenopus tropicalis	85.33	0.00e+00	1107.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence