iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000063253.5	ENSDART00000166620.1	ENSDARP00000140374.1
ENSDARG00000063253.5	ENSDART00000090286.5	ENSDARP00000084719.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.40e-121	404.8	1140	1472

Active Site

Position(s)	Description	Evidence
1440	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1140 DLQRSKLYVSFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1225
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   die++ ldltf+v+ee++g+++e+eLkpgG+nipV ++Nk+eY+++
   Q: 1226 AFFTRPFYKGLLRIPCDLSDLEYLDEEFHQSLQWMKDN---DIEDM-LDLTFTVNEEVFGQITERELKPGGANIPVSEKNKKEYIER 1308
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid+ d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1309 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLGDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1395
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ ++lP+++TCfn+L+LP+Y+s + l+ek+l+A+eet+ F+l+
   Q: 1396 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITSLPRAHTCFNRLDLPPYPSFSMLYEKMLTAVEETSTFGLE 1472
           **************************************************************************985 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MATGTTTTAR EHLLVVRRRS PHMRYTLSPE NLRSLSAQGG SGGGGSRGGA PEPMGLQRAN 60
SDTDLVTSDS RSSLTASTYQ FTLGRGQNLV ISWDIKEEVD ATDWIGLYHI DETCPANVWD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGATTTTTG GGCCCAAATC CCCTCCCCTT TTTTGGCCAT TTGGCACCCA TTTCTTGGCT 60
CCATCTCATC TCGACCTCCA CCATTCGACC CTCGCTGGCC ACGGCAGTCC TCCCTCCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

dre:100331355

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	80.55	0.00e+00	1493.00
IUUC-Apl-003935	Anas platyrhynchos	81.17	0.00e+00	1484.00
IUUC-Aca-004558	Anolis carolinensis	71.17	0.00e+00	1484.00
IUUC-Ame-010893	Astyanax mexicanus	96.07	0.00e+00	1404.00
IUUC-Bta-013093	Bos taurus	86.83	0.00e+00	1428.00
IUUC-Cja-019651	Callithrix jacchus	80.37	0.00e+00	1484.00
IUUC-Cfa-021232	Canis familiaris	89.04	0.00e+00	1464.00
IUUC-Cpo-021770	Cavia porcellus	89.38	0.00e+00	1497.00
IUUC-Csa-023970	Chlorocebus sabaeus	79.98	0.00e+00	1475.00
IUUC-Cho-024512	Choloepus hoffmanni	79.59	0.00e+00	1258.00
IUUC-Csv-026127	Ciona savignyi	66.67	2.00e-155	542.00
IUUC-Dno-029963	Dasypus novemcinctus	79.46	0.00e+00	1464.00
IUUC-Dor-031030	Dipodomys ordii	68.01	0.00e+00	764.00
IUUC-Dme-032217	Drosophila melanogaster	70.88	0.00e+00	652.00
IUUC-Ete-033132	Echinops telfairi	74.77	0.00e+00	1131.00
IUUC-Eca-033978	Equus caballus	80.44	0.00e+00	1476.00
IUUC-Fca-036157	Felis catus	80.68	0.00e+00	1473.00
IUUC-Fal-037110	Ficedula albicollis	86.05	0.00e+00	1472.00
IUUC-Gmo-039291	Gadus morhua	70.23	0.00e+00	1204.00
IUUC-Gga-040821	Gallus gallus	89.38	0.00e+00	1478.00
IUUC-Gac-042181	Gasterosteus aculeatus	88.07	0.00e+00	1468.00
IUUC-Ggo-044862	Gorilla gorilla	79.78	0.00e+00	1479.00
IUUC-Hsa-046219	Homo sapiens	79.67	0.00e+00	1505.00
IUUC-Lch-050526	Latimeria chalumnae	80.40	0.00e+00	1474.00
IUUC-Loc-052648	Lepisosteus oculatus	91.04	0.00e+00	1586.00
IUUC-Laf-054005	Loxodonta africana	80.88	0.00e+00	1498.00
IUUC-Mcc-055314	Macaca mulatta	79.98	0.00e+00	1476.00
IUUC-Meu-056356	Macropus eugenii	77.24	0.00e+00	763.00
IUUC-Mga-060074	Meleagris gallopavo	88.64	0.00e+00	1399.00
IUUC-Mmr-061526	Microcebus murinus	89.04	0.00e+00	1474.00
IUUC-Mdo-063017	Monodelphis domestica	80.50	0.00e+00	1451.00
IUUC-Mmu-064165	Mus musculus	88.92	0.00e+00	1473.00
IUUC-Mpu-065835	Mustela putorius furo	85.08	0.00e+00	1401.00
IUUC-Mlu-067709	Myotis lucifugus	84.04	0.00e+00	1446.00
IUUC-Nle-069308	Nomascus leucogenys	80.00	0.00e+00	1480.00
IUUC-Opr-070330	Ochotona princeps	73.58	0.00e+00	1232.00
IUUC-Ont-071345	Oreochromis niloticus	87.61	0.00e+00	1489.00
IUUC-Ocu-074775	Oryctolagus cuniculus	84.75	0.00e+00	1479.00
IUUC-Ola-087225	Oryzias latipes	84.29	0.00e+00	1397.00
IUUC-Oga-088177	Otolemur garnettii	84.75	0.00e+00	1478.00
IUUC-Oar-089452	Ovis aries	80.46	0.00e+00	1482.00
IUUC-Ptr-090806	Pan troglodytes	79.78	0.00e+00	1486.00
IUUC-Pan-091838	Papio anubis	79.89	0.00e+00	1470.00
IUUC-Psi-094090	Pelodiscus sinensis	87.03	0.00e+00	1432.00
IUUC-Pfo-096520	Poecilia formosa	85.37	0.00e+00	1496.00
IUUC-Pab-098405	Pongo abelii	79.78	0.00e+00	1482.00
IUUC-Pva-102324	Pteropus vampyrus	88.44	0.00e+00	1457.00
IUUC-Rno-105943	Rattus norvegicus	79.70	0.00e+00	1480.00
IUUC-Sha-106985	Sarcophilus harrisii	83.20	0.00e+00	1407.00
IUUC-Sar-113505	Sorex araneus	85.89	0.00e+00	1386.00
IUUC-Ssc-115534	Sus scrofa	96.69	0.00e+00	741.00
IUUC-Tgu-117078	Taeniopygia guttata	88.06	0.00e+00	1468.00
IUUC-Tru-118671	Takifugu rubripes	85.60	0.00e+00	1507.00
IUUC-Tsy-119379	Tarsius syrichta	71.54	0.00e+00	690.00
IUUC-Tni-120619	Tetraodon nigroviridis	90.74	0.00e+00	1480.00
IUUC-Ttr-128469	Tursiops truncatus	71.87	0.00e+00	1258.00
IUUC-Vpa-130498	Vicugna pacos	65.41	0.00e+00	1067.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence