iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.80e-122	407.2	1246	1578

Active Site

Position(s)	Description	Evidence
1546	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1246 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1331
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1332 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1414
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1415 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1501
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1502 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1578
           **************************************************************************985 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MASSAREHLL FVRRRNPQMR YTLSPENLQS LATQNSMPEN MALQRANSDT DLVTSESRSS 60
LTASMYEYTL GQAQNLIIFW DIKEEVDPSD WIGLYHIDEN SPANFWDSKN RGVTGTQKGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGCTTTGT AGGAAAACAA CCTCAGAGAG GCAGACAGGA TGGCAAGCTC AGCCCGGGAG 60
CATTTGCTTT TTGTGCGGCG TCGAAATCCA CAGATGCGGT ACACACTGAG CCCAGAGAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

KEGG

rno:316395

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	93.66	0.00e+00	2911.00
IUUC-Apl-003935	Anas platyrhynchos	84.54	0.00e+00	2685.00
IUUC-Aca-004558	Anolis carolinensis	82.43	0.00e+00	2622.00
IUUC-Ame-010893	Astyanax mexicanus	88.19	0.00e+00	1302.00
IUUC-Bta-013093	Bos taurus	96.09	0.00e+00	1577.00
IUUC-Cja-019651	Callithrix jacchus	92.67	0.00e+00	2788.00
IUUC-Cfa-021232	Canis familiaris	98.99	0.00e+00	1626.00
IUUC-Cpo-021770	Cavia porcellus	89.14	0.00e+00	2801.00
IUUC-Csa-023970	Chlorocebus sabaeus	93.79	0.00e+00	2889.00
IUUC-Cho-024512	Choloepus hoffmanni	86.25	0.00e+00	2591.00
IUUC-Csv-026127	Ciona savignyi	72.55	1.00e-155	542.00
IUUC-Dre-028275	Danio rerio	79.91	0.00e+00	1477.00
IUUC-Dno-029963	Dasypus novemcinctus	92.80	0.00e+00	2749.00
IUUC-Dor-030282	Dipodomys ordii	88.03	0.00e+00	1977.00
IUUC-Dme-032217	Drosophila melanogaster	72.11	0.00e+00	661.00
IUUC-Ete-033132	Echinops telfairi	82.78	0.00e+00	1258.00
IUUC-Eca-033978	Equus caballus	93.22	0.00e+00	2877.00
IUUC-Eeu-035278	Erinaceus europaeus	63.42	0.00e+00	1169.00
IUUC-Fca-036157	Felis catus	93.60	0.00e+00	2881.00
IUUC-Fal-037110	Ficedula albicollis	97.28	0.00e+00	1640.00
IUUC-Gmo-039291	Gadus morhua	80.16	0.00e+00	1017.00
IUUC-Gga-040821	Gallus gallus	84.51	0.00e+00	2689.00
IUUC-Gac-042456	Gasterosteus aculeatus	63.81	0.00e+00	1898.00
IUUC-Ggo-044862	Gorilla gorilla	93.80	0.00e+00	2799.00
IUUC-Hsa-046219	Homo sapiens	93.98	0.00e+00	2953.00
IUUC-Lch-050526	Latimeria chalumnae	77.27	0.00e+00	2419.00
IUUC-Loc-052648	Lepisosteus oculatus	77.97	0.00e+00	1520.00
IUUC-Laf-054005	Loxodonta africana	93.48	0.00e+00	2925.00
IUUC-Mcc-055314	Macaca mulatta	93.92	0.00e+00	2885.00
IUUC-Meu-056356	Macropus eugenii	67.94	0.00e+00	1110.00
IUUC-Mga-060074	Meleagris gallopavo	84.01	0.00e+00	2577.00
IUUC-Mmr-061526	Microcebus murinus	93.85	0.00e+00	2881.00
IUUC-Mdo-063017	Monodelphis domestica	89.94	0.00e+00	2781.00
IUUC-Mmu-064165	Mus musculus	98.10	0.00e+00	3001.00
IUUC-Mpu-065835	Mustela putorius furo	82.17	0.00e+00	1560.00
IUUC-Mlu-067709	Myotis lucifugus	89.17	0.00e+00	2726.00
IUUC-Nle-069308	Nomascus leucogenys	93.73	0.00e+00	2921.00
IUUC-Opr-070330	Ochotona princeps	80.54	0.00e+00	2364.00
IUUC-Ont-071918	Oreochromis niloticus	81.21	0.00e+00	1367.00
IUUC-Ocu-074775	Oryctolagus cuniculus	92.74	0.00e+00	2607.00
IUUC-Ola-087225	Oryzias latipes	63.56	0.00e+00	1835.00
IUUC-Oga-088177	Otolemur garnettii	91.59	0.00e+00	2767.00
IUUC-Oar-089452	Ovis aries	93.09	0.00e+00	2889.00
IUUC-Ptr-090806	Pan troglodytes	94.04	0.00e+00	2938.00
IUUC-Pan-091838	Papio anubis	93.73	0.00e+00	2772.00
IUUC-Psi-094090	Pelodiscus sinensis	84.50	0.00e+00	2677.00
IUUC-Pfo-096520	Poecilia formosa	68.28	0.00e+00	1515.00
IUUC-Pab-098405	Pongo abelii	93.92	0.00e+00	2925.00
IUUC-Pca-100441	Procavia capensis	86.99	0.00e+00	2224.00
IUUC-Pva-102324	Pteropus vampyrus	98.61	0.00e+00	1621.00
IUUC-Sha-106985	Sarcophilus harrisii	86.82	0.00e+00	2320.00
IUUC-Sar-113505	Sorex araneus	95.08	0.00e+00	1535.00
IUUC-Ssc-115439	Sus scrofa	92.22	0.00e+00	1915.00
IUUC-Tgu-117078	Taeniopygia guttata	89.75	0.00e+00	1758.00
IUUC-Tru-118671	Takifugu rubripes	80.47	0.00e+00	1446.00
IUUC-Tni-120069	Tetraodon nigroviridis	64.17	0.00e+00	1881.00
IUUC-Tbe-127975	Tupaia belangeri	91.36	0.00e+00	2419.00
IUUC-Ttr-128469	Tursiops truncatus	88.15	0.00e+00	2607.00
IUUC-Vpa-130498	Vicugna pacos	83.79	0.00e+00	2412.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence