iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.30e-10	41.4	772	828

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++v++lydy+a+ +deLt+ +G  ++ +   ++ +gW+kg    +  +  fP+n+ve ++
   Q: 772  RTVKALYDYKAKRSDELTFCRGALIHNV--SKEPGGWWKGD-YGTRIQQYFPSNYVEDIS 828
           789************************9..77889*****6.55556679******9885 PP

Organism

Mus musculus

Functional Description
(View)

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (By similarity).

Protein Sequence
(Fasta)

MTTMVNVDTL PEYEKSQIKR ALELGTVMTV FNARKSTPER RTVQMIMETR QVAWSKTADK 60
IEGFLDIMEI KEIRPGKNSK DFERAKAVRH KAECCFTILY GTQFVLSTLS LATDSKEDAV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCCGCTGA GCAAGACCTG CGCTGCCGGA CTGCCCGGGC CCCAGGCGGC TGCTGCACGA 60
GGGACCCCCG AGTCCCCCCA ACCCGTGGCT GGCAGGCCCA GGGATTGTGC GGGTGGCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0106--Calcium
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0807--Transducer

Interpro

IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR016279--PLC-gamma
IPR028381--PLC-gamma2
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS50003--PH_DOMAIN
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3

Pfam

PF00168--C2
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN

SMART

SM00239--C2
SM00233--PH
SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0004629--F:phospholipase C activity
GO:0004871--F:signal transducer activity
GO:0032237--P:activation of store-operated calcium channel activity
GO:0030183--P:B cell differentiation
GO:0050853--P:B cell receptor signaling pathway
GO:0002316--P:follicular B cell differentiation
GO:0032959--P:inositol trisphosphate biosynthetic process
GO:0035556--P:intracellular signal transduction
GO:0043069--P:negative regulation of programmed cell death
GO:0006661--P:phosphatidylinositol biosynthetic process
GO:0009395--P:phospholipid catabolic process
GO:0002092--P:positive regulation of receptor internalization
GO:0032481--P:positive regulation of type I interferon production
GO:0010468--P:regulation of gene expression
GO:0051209--P:release of sequestered calcium ion into cytosol
GO:0032496--P:response to lipopolysaccharide
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0050852--P:T cell receptor signaling pathway

KEGG

mmu:234779

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003345	Anas platyrhynchos	82.22	0.00e+00	2021.00
IUUC-Aca-004266	Anolis carolinensis	79.79	0.00e+00	2116.00
IUUC-Ame-011540	Astyanax mexicanus	58.58	0.00e+00	1427.00
IUUC-Bta-013196	Bos taurus	93.17	0.00e+00	2362.00
IUUC-Cpo-021890	Cavia porcellus	92.05	0.00e+00	2459.00
IUUC-Csa-024233	Chlorocebus sabaeus	93.75	0.00e+00	2478.00
IUUC-Dre-028650	Danio rerio	58.59	0.00e+00	1440.00
IUUC-Dno-028871	Dasypus novemcinctus	92.86	0.00e+00	2385.00
IUUC-Eca-033458	Equus caballus	94.23	0.00e+00	2485.00
IUUC-Eeu-035329	Erinaceus europaeus	88.95	0.00e+00	2352.00
IUUC-Fal-037390	Ficedula albicollis	81.85	0.00e+00	2169.00
IUUC-Gga-040918	Gallus gallus	82.33	0.00e+00	2155.00
IUUC-Ggo-045625	Gorilla gorilla	93.12	0.00e+00	2477.00
IUUC-Hsa-046129	Homo sapiens	94.15	0.00e+00	2516.00
IUUC-Loc-052025	Lepisosteus oculatus	61.76	0.00e+00	1580.00
IUUC-Mcc-054831	Macaca mulatta	93.76	0.00e+00	2414.00
IUUC-Mga-059368	Meleagris gallopavo	82.49	0.00e+00	2142.00
IUUC-Mmr-060898	Microcebus murinus	90.82	0.00e+00	2250.00
IUUC-Mlu-067230	Myotis lucifugus	93.21	0.00e+00	2482.00
IUUC-Nle-069318	Nomascus leucogenys	88.09	0.00e+00	2286.00
IUUC-Opr-070718	Ochotona princeps	79.39	0.00e+00	1082.00
IUUC-Ocu-073814	Oryctolagus cuniculus	92.81	0.00e+00	2460.00
IUUC-Ola-086501	Oryzias latipes	56.93	0.00e+00	1438.00
IUUC-Oga-088036	Otolemur garnettii	93.44	0.00e+00	1798.00
IUUC-Oar-089556	Ovis aries	93.12	0.00e+00	2366.00
IUUC-Ptr-091001	Pan troglodytes	94.31	0.00e+00	2518.00
IUUC-Pan-092744	Papio anubis	94.07	0.00e+00	2483.00
IUUC-Psi-093987	Pelodiscus sinensis	82.49	0.00e+00	2176.00
IUUC-Pfo-096249	Poecilia formosa	57.74	0.00e+00	1480.00
IUUC-Pab-098268	Pongo abelii	91.78	0.00e+00	2431.00
IUUC-Pva-102939	Pteropus vampyrus	90.67	0.00e+00	2273.00
IUUC-Sre-115229	Sporisorium reilianum	43.33	2.00e-09	59.30
IUUC-Ssc-115308	Sus scrofa	87.89	0.00e+00	2157.00
IUUC-Tgu-116811	Taeniopygia guttata	81.85	0.00e+00	2167.00
IUUC-Tru-117536	Takifugu rubripes	56.87	0.00e+00	1423.00
IUUC-Tsy-119139	Tarsius syrichta	83.88	0.00e+00	960.00
IUUC-Ttr-128392	Tursiops truncatus	90.12	0.00e+00	2353.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence