iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nle-069318

Ensembl Protein ID

ENSNLEP00000012984.2

UniProt Accession

G1RIC8; G1RIC8_NOMLE

Genbank Protein ID

ENSNLEP00000012984

Protein Name

Phosphoinositide phospholipase C

Genbank Nucleotide ID

ADFV01071306

Gene Name

PLCG2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000010678.2	ENSNLET00000013621.2	ENSNLEP00000012984.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.80e-10	40.6	781	837

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++v++lydy+a+ +deL++ +G  ++ +   ++ +gW+kg    +  +  fP+n+ve ++
   Q: 781  RTVKALYDYKAKRSDELSFCRGALIHNV--SKEPGGWWKGD-YGTRIQQYFPSNYVEDIS 837
           789************************9..77889*****6.55556679******9985 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MDDSAEWPTM STIVNVDSLA EYEKSQIKRA LELGTVMTVF SFRKSTPERR TVQVIMETRQ 60
VAWSKTADKI EGFLDIMEIK EIRPGKNSKD FERAKAVRQK EDCCFTILYG TQFVLSTLSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGATT CTGCAGGTTT GGTTTGTTTT TCGTTTATTT CATTTTTTTT TATTGTTGTT 60
CTTAATTTGG CTCAGGAATA AAGAGATGGT TAGAAATCTC TAGACGGGAT AGAGAAGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0807--Transducer

Interpro

IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR016279--PLC-gamma
IPR028381--PLC-gamma2
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS50003--PH_DOMAIN
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3

Pfam

PF00168--C2
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00239--C2
SM00233--PH
SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005622--C:intracellular
GO:0005886--C:plasma membrane
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0004871--F:signal transducer activity
GO:0035556--P:intracellular signal transduction
GO:0006661--P:phosphatidylinositol biosynthetic process
GO:0009395--P:phospholipid catabolic process
GO:0051209--P:release of sequestered calcium ion into cytosol

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003345	Anas platyrhynchos	77.80	0.00e+00	1859.00
IUUC-Aca-004266	Anolis carolinensis	75.59	0.00e+00	1951.00
IUUC-Ame-011540	Astyanax mexicanus	54.68	0.00e+00	1299.00
IUUC-Bta-013196	Bos taurus	87.34	0.00e+00	2186.00
IUUC-Cpo-021890	Cavia porcellus	87.42	0.00e+00	2295.00
IUUC-Csa-024233	Chlorocebus sabaeus	92.41	0.00e+00	2383.00
IUUC-Dre-028650	Danio rerio	54.49	0.00e+00	1305.00
IUUC-Dno-028871	Dasypus novemcinctus	88.76	0.00e+00	2237.00
IUUC-Eca-033458	Equus caballus	90.36	0.00e+00	2350.00
IUUC-Eeu-035329	Erinaceus europaeus	84.53	0.00e+00	2193.00
IUUC-Fal-037390	Ficedula albicollis	77.97	0.00e+00	2014.00
IUUC-Gga-040918	Gallus gallus	78.37	0.00e+00	2004.00
IUUC-Ggo-045625	Gorilla gorilla	92.81	0.00e+00	2414.00
IUUC-Hsa-046129	Homo sapiens	92.96	0.00e+00	2418.00
IUUC-Loc-052025	Lepisosteus oculatus	57.27	0.00e+00	1424.00
IUUC-Mcc-054831	Macaca mulatta	92.22	0.00e+00	2315.00
IUUC-Mga-059368	Meleagris gallopavo	78.45	0.00e+00	1988.00
IUUC-Mmr-060898	Microcebus murinus	87.65	0.00e+00	2116.00
IUUC-Mmu-064334	Mus musculus	88.09	0.00e+00	2275.00
IUUC-Mlu-067230	Myotis lucifugus	89.10	0.00e+00	2335.00
IUUC-Opr-070718	Ochotona princeps	75.99	0.00e+00	1019.00
IUUC-Ocu-073814	Oryctolagus cuniculus	87.99	0.00e+00	2295.00
IUUC-Ola-086501	Oryzias latipes	52.88	0.00e+00	1333.00
IUUC-Oga-088036	Otolemur garnettii	88.18	0.00e+00	1653.00
IUUC-Oar-089556	Ovis aries	87.73	0.00e+00	2189.00
IUUC-Ptr-091001	Pan troglodytes	92.96	0.00e+00	2419.00
IUUC-Pan-092744	Papio anubis	92.57	0.00e+00	2387.00
IUUC-Psi-093987	Pelodiscus sinensis	78.48	0.00e+00	2018.00
IUUC-Pfo-096249	Poecilia formosa	54.47	0.00e+00	1352.00
IUUC-Pab-098268	Pongo abelii	90.20	0.00e+00	2325.00
IUUC-Pva-102939	Pteropus vampyrus	86.33	0.00e+00	2129.00
IUUC-Ssc-115308	Sus scrofa	82.93	0.00e+00	1997.00
IUUC-Tgu-116811	Taeniopygia guttata	78.05	0.00e+00	2017.00
IUUC-Tru-117536	Takifugu rubripes	53.32	0.00e+00	1295.00
IUUC-Tsy-119139	Tarsius syrichta	84.92	0.00e+00	965.00
IUUC-Ttr-128392	Tursiops truncatus	86.40	0.00e+00	2208.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence