iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-090461

Ensembl Protein ID

ENSPTRP00000026335.2

UniProt Accession

H2QN71; H2QN71_PANTR

Genbank Protein ID

JAA37087.1

Protein Name

Hematopoietic cell-specific Lyn substrate 1

Genbank Nucleotide ID

AACZ03024439

Gene Name

HCLS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000015279.2	ENSPTRT00000028535.2	ENSPTRP00000026335.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.70e-12	46.4	432	483

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
            +lydy+++ +deL++   dv++ i  e  degW++g    +g  GlfP+n+v+ l
   Q: 432  VALYDYQGEGSDELSFDPDDVITDI--EMVDEGWWRG--RCHGHFGLFPANYVKLL 483
           58**********************9..9*********..8*************977 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MWKSVVGHDV SVSVETQGDD WDTDPDFVND ISEKEQRWGA KTIEGSGRTE HINIHQLRNK 60
VSEEHDVLKK KEMESGPKAS HGYGGRFGVE RDRMDKSAVG HEYVAEVEKH SSQTDAAKGF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAAACCTGA ATACGGAACT GAAGCAGCAG CTCAGTTTCT CACTCCGAAG TGGCAGAAGC 60
CAGAGAGGGA GTCGGTGTGG ACGCGAGGAG CCGGGCGCTT AGAACAGAGG CTTGCACAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR028534--HS1
IPR003134--Hs1_Cortactin
IPR001452--SH3_domain

PROSITE

PS51090--CORTACTIN
PS50002--SH3

Pfam

PF02218--HS1_rep
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005667--C:transcription factor complex
GO:0030041--P:actin filament polymerization
GO:0071345--P:cellular response to cytokine stimulus
GO:0030218--P:erythrocyte differentiation
GO:2000107--P:negative regulation of leukocyte apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0008284--P:positive regulation of cell proliferation
GO:0030854--P:positive regulation of granulocyte differentiation
GO:0045651--P:positive regulation of macrophage differentiation
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0030833--P:regulation of actin filament polymerization
GO:0009725--P:response to hormone

KEGG

ptr:460623

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001194	Ailuropoda melanoleuca	84.25	0.00e+00	726.00
IUUC-Apl-003745	Anas platyrhynchos	57.71	3.00e-84	305.00
IUUC-Aca-004438	Anolis carolinensis	64.84	2.00e-80	293.00
IUUC-Ame-011504	Astyanax mexicanus	71.83	3.00e-79	289.00
IUUC-Bta-012591	Bos taurus	86.68	0.00e+00	678.00
IUUC-Cja-019982	Callithrix jacchus	90.37	0.00e+00	730.00
IUUC-Cfa-020262	Canis familiaris	82.93	0.00e+00	649.00
IUUC-Cpo-021362	Cavia porcellus	84.09	0.00e+00	640.00
IUUC-Csa-023911	Chlorocebus sabaeus	94.83	0.00e+00	746.00
IUUC-Cin-025677	Ciona intestinalis	55.56	2.00e-66	246.00
IUUC-Csv-026140	Ciona savignyi	59.68	7.00e-64	238.00
IUUC-Dre-028127	Danio rerio	71.83	2.00e-94	339.00
IUUC-Dno-029332	Dasypus novemcinctus	64.32	7.00e-90	324.00
IUUC-Dor-030437	Dipodomys ordii	77.23	2.00e-170	592.00
IUUC-Dme-031931	Drosophila melanogaster	47.77	3.00e-71	262.00
IUUC-Ete-033160	Echinops telfairi	77.41	6.00e-157	546.00
IUUC-Eca-033269	Equus caballus	84.41	0.00e+00	717.00
IUUC-Eeu-035032	Erinaceus europaeus	71.83	2.00e-122	432.00
IUUC-Fca-035999	Felis catus	81.87	0.00e+00	749.00
IUUC-Fal-037107	Ficedula albicollis	65.85	8.00e-107	380.00
IUUC-Gmo-038507	Gadus morhua	64.29	5.00e-18	85.90
IUUC-Gga-040335	Gallus gallus	68.20	4.00e-107	381.00
IUUC-Gac-042253	Gasterosteus aculeatus	69.48	2.00e-88	319.00
IUUC-Ggo-044505	Gorilla gorilla	99.17	0.00e+00	763.00
IUUC-Hsa-046728	Homo sapiens	93.21	0.00e+00	739.00
IUUC-Itr-048592	Ictidomys tridecemlineatus	66.97	2.00e-165	575.00
IUUC-Lch-050221	Latimeria chalumnae	78.70	1.00e-100	360.00
IUUC-Loc-052855	Lepisosteus oculatus	61.57	5.00e-86	311.00
IUUC-Laf-054202	Loxodonta africana	82.69	0.00e+00	667.00
IUUC-Mcc-055824	Macaca mulatta	90.91	0.00e+00	743.00
IUUC-Mga-059791	Meleagris gallopavo	56.92	1.00e-83	303.00
IUUC-Mmr-061281	Microcebus murinus	79.18	1.00e-173	602.00
IUUC-Mdo-062515	Monodelphis domestica	70.55	3.00e-153	534.00
IUUC-Mmu-064341	Mus musculus	82.76	0.00e+00	678.00
IUUC-Mpu-066565	Mustela putorius furo	84.71	0.00e+00	686.00
IUUC-Mlu-066942	Myotis lucifugus	82.02	0.00e+00	681.00
IUUC-Nle-069436	Nomascus leucogenys	95.03	0.00e+00	753.00
IUUC-Opr-070288	Ochotona princeps	77.98	3.00e-167	581.00
IUUC-Ont-071712	Oreochromis niloticus	74.65	3.00e-92	332.00
IUUC-Oan-073528	Ornithorhynchus anatinus	42.03	1.00e-44	174.00
IUUC-Ocu-074686	Oryctolagus cuniculus	85.10	0.00e+00	629.00
IUUC-Ola-086894	Oryzias latipes	60.14	6.00e-95	341.00
IUUC-Oga-088585	Otolemur garnettii	77.37	0.00e+00	660.00
IUUC-Oar-089686	Ovis aries	87.12	0.00e+00	709.00
IUUC-Pan-091887	Papio anubis	93.39	0.00e+00	730.00
IUUC-Psi-093785	Pelodiscus sinensis	52.80	6.00e-140	490.00
IUUC-Pma-094161	Petromyzon marinus	63.58	5.00e-56	211.00
IUUC-Pfo-097391	Poecilia formosa	69.48	4.00e-90	325.00
IUUC-Pab-098222	Pongo abelii	95.66	0.00e+00	748.00
IUUC-Pca-100668	Procavia capensis	82.37	0.00e+00	671.00
IUUC-Pva-102767	Pteropus vampyrus	74.79	1.00e-170	592.00
IUUC-Rno-106001	Rattus norvegicus	85.01	0.00e+00	682.00
IUUC-Sha-106912	Sarcophilus harrisii	53.39	7.00e-136	477.00
IUUC-Sar-113338	Sorex araneus	76.52	4.00e-171	593.00
IUUC-Ssc-116027	Sus scrofa	85.48	0.00e+00	721.00
IUUC-Tgu-117472	Taeniopygia guttata	58.74	2.00e-152	531.00
IUUC-Tru-118718	Takifugu rubripes	64.62	5.00e-84	305.00
IUUC-Tni-119931	Tetraodon nigroviridis	42.39	6.00e-108	384.00
IUUC-Xtr-131797	Xenopus tropicalis	68.54	4.00e-81	295.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence