iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-105542

Ensembl Protein ID

ENSRNOP00000012936.6

UniProt Accession

A0A0H2UHH7; A0A0H2UHH7_RAT

Genbank Protein ID

ENSRNOP00000012936

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AC132627

Gene Name

Lck

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000009705.6	ENSRNOT00000012936.6	ENSRNOP00000012936.6

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.30e-19	69.0	73	131

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++v++l++ye+++d++L ++kG++++++   eq+++W+k+++ ++g++G++P nFv+k++
   Q: 73   QDNLVIALHSYEPSHDGDLGFEKGEQLRIL---EQSGEWWKAQSLTTGQEGFIPFNFVAKAN 131
           6899**************************...**************************987 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MGASELTISG IMGCVCSSNP EDDWMENIDV CENCHYPIVP LDSKSTLPIR TGSEVRDPLV 60
TYEGSLPPAS PLQDNLVIAL HSYEPSHDGD LGFEKGEQLR ILEQSGEWWK AQSLTTGQEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTCCTGTG AACTCGTTGC TTGAGGGCTC GGAGTAAACC CAGTGGGAAA CTAGAATTCC 60
ACTTTTCAGC TCTTCTGTCT ACGGCCAATG GGGGCCTCTG AGCTGACAAT CTCAGGTAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0001772--C:immunological synapse
GO:0045121--C:membrane raft
GO:0000242--C:pericentriolar material
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006882--P:cellular zinc ion homeostasis
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0050870--P:positive regulation of T cell activation
GO:0042493--P:response to drug
GO:0030217--P:T cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001315	Ailuropoda melanoleuca	91.47	0.00e+00	1021.00
IUUC-Apl-004134	Anas platyrhynchos	80.09	0.00e+00	735.00
IUUC-Bta-013264	Bos taurus	94.89	0.00e+00	1020.00
IUUC-Cja-019574	Callithrix jacchus	93.44	0.00e+00	707.00
IUUC-Cfa-021161	Canis familiaris	90.17	0.00e+00	1010.00
IUUC-Cpo-022492	Cavia porcellus	94.11	0.00e+00	1004.00
IUUC-Csa-023270	Chlorocebus sabaeus	76.82	0.00e+00	789.00
IUUC-Dre-028005	Danio rerio	74.11	0.00e+00	714.00
IUUC-Dno-029365	Dasypus novemcinctus	93.15	0.00e+00	989.00
IUUC-Dor-030892	Dipodomys ordii	90.84	0.00e+00	943.00
IUUC-Eca-033325	Equus caballus	93.73	0.00e+00	993.00
IUUC-Eeu-035004	Erinaceus europaeus	87.30	0.00e+00	793.00
IUUC-Fca-035908	Felis catus	96.46	0.00e+00	1035.00
IUUC-Fal-036804	Ficedula albicollis	69.98	0.00e+00	722.00
IUUC-Gmo-038984	Gadus morhua	63.62	0.00e+00	695.00
IUUC-Gga-040997	Gallus gallus	81.93	0.00e+00	900.00
IUUC-Gac-041854	Gasterosteus aculeatus	69.02	0.00e+00	734.00
IUUC-Ggo-045238	Gorilla gorilla	91.28	0.00e+00	1016.00
IUUC-Hsa-047039	Homo sapiens	96.66	0.00e+00	1031.00
IUUC-Hvu-047815	Hordeum vulgare	29.47	3.00e-21	97.10
IUUC-Itr-048479	Ictidomys tridecemlineatus	96.66	0.00e+00	1035.00
IUUC-Lch-049568	Latimeria chalumnae	77.19	0.00e+00	847.00
IUUC-Loc-052222	Lepisosteus oculatus	67.18	0.00e+00	674.00
IUUC-Laf-054499	Loxodonta africana	90.35	0.00e+00	1013.00
IUUC-Mcc-054872	Macaca mulatta	76.54	0.00e+00	847.00
IUUC-Meu-056879	Macropus eugenii	90.06	0.00e+00	970.00
IUUC-Mga-059971	Meleagris gallopavo	81.34	0.00e+00	891.00
IUUC-Mmr-060740	Microcebus murinus	95.68	0.00e+00	1026.00
IUUC-Mdo-062192	Monodelphis domestica	91.75	0.00e+00	990.00
IUUC-Mmu-064241	Mus musculus	99.23	0.00e+00	1080.00
IUUC-Mpu-066595	Mustela putorius furo	95.87	0.00e+00	1027.00
IUUC-Mlu-067069	Myotis lucifugus	94.90	0.00e+00	1017.00
IUUC-Opr-070472	Ochotona princeps	90.64	0.00e+00	1006.00
IUUC-Ont-071711	Oreochromis niloticus	68.43	0.00e+00	706.00
IUUC-Ocu-074221	Oryctolagus cuniculus	95.29	0.00e+00	1019.00
IUUC-Ola-087000	Oryzias latipes	68.50	0.00e+00	731.00
IUUC-Oga-088225	Otolemur garnettii	95.09	0.00e+00	1018.00
IUUC-Oar-090244	Ovis aries	83.54	0.00e+00	955.00
IUUC-Ptr-090751	Pan troglodytes	96.86	0.00e+00	716.00
IUUC-Pan-091804	Papio anubis	95.68	0.00e+00	1016.00
IUUC-Psi-093252	Pelodiscus sinensis	73.27	0.00e+00	796.00
IUUC-Pfo-096542	Poecilia formosa	67.31	0.00e+00	732.00
IUUC-Pab-098168	Pongo abelii	96.10	0.00e+00	977.00
IUUC-Pca-100547	Procavia capensis	95.64	0.00e+00	645.00
IUUC-Sha-107524	Sarcophilus harrisii	90.77	0.00e+00	983.00
IUUC-Stu-112331	Solanum tuberosum	30.80	8.00e-23	102.00
IUUC-Sar-113235	Sorex araneus	88.32	0.00e+00	857.00
IUUC-Ssc-115624	Sus scrofa	95.09	0.00e+00	1022.00
IUUC-Tru-118559	Takifugu rubripes	67.05	0.00e+00	724.00
IUUC-Tca-121341	Theobroma cacao	36.27	3.00e-22	100.00
IUUC-Ttr-129002	Tursiops truncatus	86.09	0.00e+00	947.00
IUUC-Xtr-132224	Xenopus tropicalis	74.85	0.00e+00	827.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence