iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000043008.8	ENSMUST00000058839.8	ENSMUSP00000053023.8
ENSMUSG00000043008.8	ENSMUST00000165530.1	ENSMUSP00000133197.1
ENSMUSG00000043008.8	ENSMUST00000166801.1	ENSMUSP00000130755.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	2.90e-18	67.1	70	133
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	4.90e-11	41.7	169	199

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkl 65
           +Dvil+v+ +ef++h++vLaa+S +F+a+f ++l+e+  ++++ ik+v++e + +ll + Yt+k+
   Q: 70   TDVILCVDVQEFSCHRVVLAAASNYFRAMFCNDLKEKY-EKRIIIKGVDAETMHTLLVYTYTSKA 133
           7***********************************97.***********************987 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           +eNc+gilr+Ad+++++ Lk +++++i+++F
   Q: 169  PENCIGILRLADTHSLDSLKMQVQSYIIQNF 199
           89***************************** PP

Organism

Mus musculus

Functional Description
(View)

Involved in B-lymphocyte antigen receptor signaling and germinal center formation.

Protein Sequence
(Fasta)

MAGQRGACTM SDVVERSLEG PLALTTDKSS QKRGDLVEIL TGEKVKFDDT RLSLILQNGL 60
ETLREENALT DVILCVDVQE FSCHRVVLAA ASNYFRAMFC NDLKEKYEKR IIIKGVDAET 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGAAACTTG GCAGCTCCTT TAGTCTAGAC GTTGATGGCA GGACAAAGAG GCGCCTGCAC 60
CATGAGCGAT GTGGTAGAGA GGAGCTTGGA AGGACCCTTA GCACTGACTA CAGACAAGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR029851--KLHL6
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0000976--F:transcription regulatory region sequence-specific DNA binding
GO:0050853--P:B cell receptor signaling pathway
GO:0002467--P:germinal center formation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

KEGG

mmu:239743

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001509	Ailuropoda melanoleuca	94.83	0.00e+00	1228.00
IUUC-Apl-003490	Anas platyrhynchos	83.11	0.00e+00	1083.00
IUUC-Aca-005136	Anolis carolinensis	83.42	0.00e+00	1059.00
IUUC-Ame-010886	Astyanax mexicanus	65.69	0.00e+00	821.00
IUUC-Bta-013473	Bos taurus	94.83	0.00e+00	1199.00
IUUC-Cja-018888	Callithrix jacchus	93.61	0.00e+00	1196.00
IUUC-Cpo-021761	Cavia porcellus	86.37	0.00e+00	1092.00
IUUC-Csa-023206	Chlorocebus sabaeus	94.83	0.00e+00	1223.00
IUUC-Cin-025367	Ciona intestinalis	40.61	1.00e-130	459.00
IUUC-Csv-026076	Ciona savignyi	40.85	2.00e-123	436.00
IUUC-Dre-027948	Danio rerio	72.87	0.00e+00	895.00
IUUC-Dno-030045	Dasypus novemcinctus	93.86	0.00e+00	1213.00
IUUC-Dor-030839	Dipodomys ordii	86.75	0.00e+00	1092.00
IUUC-Ete-033161	Echinops telfairi	88.70	9.00e-152	530.00
IUUC-Eca-033608	Equus caballus	94.51	0.00e+00	1196.00
IUUC-Eeu-034640	Erinaceus europaeus	92.13	0.00e+00	1183.00
IUUC-Fca-036065	Felis catus	94.02	0.00e+00	1218.00
IUUC-Fal-036949	Ficedula albicollis	83.84	0.00e+00	1070.00
IUUC-Gmo-039661	Gadus morhua	57.53	2.00e-172	598.00
IUUC-Gga-040740	Gallus gallus	82.30	0.00e+00	1075.00
IUUC-Gac-042413	Gasterosteus aculeatus	61.25	0.00e+00	770.00
IUUC-Ggo-045167	Gorilla gorilla	94.51	0.00e+00	1219.00
IUUC-Hsa-046120	Homo sapiens	94.67	0.00e+00	1221.00
IUUC-Itr-047926	Ictidomys tridecemlineatus	94.02	0.00e+00	1218.00
IUUC-Lch-049709	Latimeria chalumnae	77.49	0.00e+00	1019.00
IUUC-Loc-052239	Lepisosteus oculatus	76.54	0.00e+00	972.00
IUUC-Laf-054511	Loxodonta africana	93.28	0.00e+00	1195.00
IUUC-Mcc-055109	Macaca mulatta	94.83	0.00e+00	1224.00
IUUC-Meu-056522	Macropus eugenii	73.11	3.00e-102	365.00
IUUC-Mga-060012	Meleagris gallopavo	80.61	0.00e+00	1053.00
IUUC-Mmr-061364	Microcebus murinus	94.35	0.00e+00	1220.00
IUUC-Mdo-063033	Monodelphis domestica	81.33	0.00e+00	1001.00
IUUC-Mlu-068233	Myotis lucifugus	93.54	0.00e+00	1194.00
IUUC-Opr-070638	Ochotona princeps	92.19	0.00e+00	858.00
IUUC-Ont-071960	Oreochromis niloticus	62.25	0.00e+00	784.00
IUUC-Oan-073406	Ornithorhynchus anatinus	81.80	0.00e+00	1046.00
IUUC-Ocu-074612	Oryctolagus cuniculus	93.71	0.00e+00	1210.00
IUUC-Ola-087181	Oryzias latipes	59.54	0.00e+00	756.00
IUUC-Oga-088955	Otolemur garnettii	94.35	0.00e+00	1219.00
IUUC-Oar-089682	Ovis aries	94.83	0.00e+00	1200.00
IUUC-Ptr-090969	Pan troglodytes	94.51	0.00e+00	1218.00
IUUC-Pan-092289	Papio anubis	94.83	0.00e+00	1223.00
IUUC-Psi-093279	Pelodiscus sinensis	83.58	0.00e+00	1092.00
IUUC-Pab-097957	Pongo abelii	95.82	0.00e+00	912.00
IUUC-Pca-100619	Procavia capensis	90.31	0.00e+00	1178.00
IUUC-Pva-102533	Pteropus vampyrus	92.63	0.00e+00	714.00
IUUC-Rno-106111	Rattus norvegicus	98.87	0.00e+00	1277.00
IUUC-Sha-106716	Sarcophilus harrisii	82.32	0.00e+00	1058.00
IUUC-Tgu-116839	Taeniopygia guttata	83.77	0.00e+00	1088.00
IUUC-Tru-117792	Takifugu rubripes	60.30	0.00e+00	756.00
IUUC-Tsy-119609	Tarsius syrichta	87.71	1.00e-153	536.00
IUUC-Tni-119682	Tetraodon nigroviridis	60.96	0.00e+00	759.00
IUUC-Tme-127039	Tuber melanosporum	31.37	5.00e-12	67.00
IUUC-Tbe-127961	Tupaia belangeri	88.85	0.00e+00	1087.00
IUUC-Ttr-128917	Tursiops truncatus	93.26	0.00e+00	1012.00
IUUC-Vpa-130721	Vicugna pacos	95.74	0.00e+00	847.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence