iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pma-094347

UUCD1 version

UUC-PeM-00444

Ensembl Protein ID

ENSPMAP00000005402.1

UniProt Accession

S4RJL9; S4RJL9_PETMA

Protein Name

Histone deacetylase

Gene Name

HDAC7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPMAG00000004812.1	ENSPMAT00000005422.1	ENSPMAP00000005402.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	70.33	0.00e+00	704.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Petromyzon marinus

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

TMPAVDPAAR EQQLQTELLQ LKQQHQLQQQ LLLADFQQRQ EQLARQHQAQ LHDYIKQQQQ 60
VLALKKQQEL LAVQRRERER LEQQKRELEL ELELESQRHE QHLQVLRNKE RGRESAVASS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGATGCCAG CCGTGGACCC TGCAGCGCGT GAGCAGCAGC TGCAGACTGA GCTGCTGCAG 60
CTGAAGCAGC AGCACCAGCT TCAGCAGCAG CTGCTGCTCG CAGATTTCCA GCAGAGGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0046872--F:metal ion binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	56.24	0.00e+00	934.00
IUUC-Apl-003250	Anas platyrhynchos	71.63	0.00e+00	746.00
IUUC-Aca-004668	Anolis carolinensis	69.31	0.00e+00	744.00
IUUC-Bta-013215	Bos taurus	57.07	0.00e+00	944.00
IUUC-Cja-019816	Callithrix jacchus	68.97	0.00e+00	746.00
IUUC-Cfa-020861	Canis familiaris	55.64	0.00e+00	917.00
IUUC-Cpo-021562	Cavia porcellus	69.11	0.00e+00	756.00
IUUC-Cre-022561	Chlamydomonas reinhardtii	50.66	5.00e-56	209.00
IUUC-Csa-023612	Chlorocebus sabaeus	69.42	0.00e+00	750.00
IUUC-Csv-026359	Ciona savignyi	54.39	9.00e-93	331.00
IUUC-Cne-026978	Cryptococcus neoformans	40.19	3.00e-80	291.00
IUUC-Dre-028284	Danio rerio	70.32	0.00e+00	698.00
IUUC-Dno-029951	Dasypus novemcinctus	65.77	0.00e+00	693.00
IUUC-Dor-030362	Dipodomys ordii	52.92	8.00e-147	513.00
IUUC-Dme-031766	Drosophila melanogaster	60.82	1.00e-158	553.00
IUUC-Fca-036187	Felis catus	56.16	0.00e+00	952.00
IUUC-Gmo-038473	Gadus morhua	64.66	3.00e-175	607.00
IUUC-Gga-040501	Gallus gallus	71.83	0.00e+00	748.00
IUUC-Gac-042335	Gasterosteus aculeatus	69.40	0.00e+00	684.00
IUUC-Ggo-045380	Gorilla gorilla	68.85	0.00e+00	717.00
IUUC-Hsa-046925	Homo sapiens	70.22	0.00e+00	736.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	69.11	0.00e+00	751.00
IUUC-Lch-050325	Latimeria chalumnae	69.42	0.00e+00	725.00
IUUC-Loc-052231	Lepisosteus oculatus	71.11	0.00e+00	702.00
IUUC-Laf-054490	Loxodonta africana	69.79	0.00e+00	710.00
IUUC-Mcc-055265	Macaca mulatta	69.42	0.00e+00	751.00
IUUC-Meu-056676	Macropus eugenii	66.42	5.00e-156	543.00
IUUC-Mmr-061633	Microcebus murinus	67.63	0.00e+00	709.00
IUUC-Mmu-063089	Mus musculus	70.02	0.00e+00	734.00
IUUC-Mpu-065887	Mustela putorius furo	55.92	0.00e+00	932.00
IUUC-Mlu-067470	Myotis lucifugus	68.73	0.00e+00	748.00
IUUC-Nle-069099	Nomascus leucogenys	76.65	1.00e-75	276.00
IUUC-Ont-071613	Oreochromis niloticus	69.46	0.00e+00	672.00
IUUC-Oan-073275	Ornithorhynchus anatinus	68.38	0.00e+00	747.00
IUUC-Ola-087031	Oryzias latipes	69.04	0.00e+00	687.00
IUUC-Oga-088201	Otolemur garnettii	71.18	0.00e+00	714.00
IUUC-Oar-089997	Ovis aries	67.37	0.00e+00	714.00
IUUC-Ptr-091116	Pan troglodytes	69.23	0.00e+00	749.00
IUUC-Pan-092132	Papio anubis	69.42	0.00e+00	746.00
IUUC-Psi-093734	Pelodiscus sinensis	70.82	0.00e+00	716.00
IUUC-Pfo-096293	Poecilia formosa	69.46	0.00e+00	692.00
IUUC-Pab-098491	Pongo abelii	63.85	0.00e+00	656.00
IUUC-Pva-102961	Pteropus vampyrus	45.86	2.00e-97	348.00
IUUC-Rno-105005	Rattus norvegicus	69.76	0.00e+00	727.00
IUUC-Sha-107646	Sarcophilus harrisii	64.21	2.00e-150	525.00
IUUC-Ssc-115428	Sus scrofa	72.18	0.00e+00	732.00
IUUC-Tgu-116776	Taeniopygia guttata	71.83	0.00e+00	748.00
IUUC-Tru-118180	Takifugu rubripes	70.32	0.00e+00	690.00
IUUC-Tsy-119468	Tarsius syrichta	61.21	4.00e-105	374.00
IUUC-Tni-120196	Tetraodon nigroviridis	69.46	0.00e+00	681.00
IUUC-Ttr-128360	Tursiops truncatus	65.64	0.00e+00	691.00
IUUC-Xtr-132956	Xenopus tropicalis	67.05	0.00e+00	716.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence