iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-089131

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAQR03165288

Gene Name

USP22

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000015801.2	ENSOGAT00000015806.2	ENSOGAP00000014153.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.00e-92	310.9	275	618

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ ++++++ +   +p+ +l++++ +lf+e+++++++   p +ll+ +++ a+++ gyeqq
   Q: 275  GLINLGNTCFMNCIVQALTHTPLLRDFFLS-DRHRCEMQ---SPSSCLVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQ 359
           9*****************************.99999875...78********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl   ld l++++k                  ++ ++ +++++ +++i+++F g l+s+++c+ c+ vs++ +pf+d+sl++pg+
   Q: 360  DAHEFLIAALDVLHRHCKG----------------DDNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGS 432
           *****************22................22335677899999**************************************** PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
           ++   +                    +l+dcL+ ft++e+l ++ k++c+ c+++qe++k+l++kklP v ++hLkRf  +++ k r+k
   Q: 433  STPFWPlspgsegsvvngeshvsgttTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRF--EHSAKLRRK 519
           *877779***********************************************************************..5666899** PP
   S: 249  inkkvefpleLdlspfctspeekqke............kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevlee 325
           i+++v+fpleLd++pf++s++e+  +            ++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + ++vl  
   Q: 520  ITTYVSFPLELDMTPFMASSKESRMNgqyqqpvdslssDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAIITKASIKDVLD- 607
           *******************7766666888888888888**************************************************. PP
   S: 326  tgstaYvlfYkrr 338
             s++Y+lfY+++
   Q: 608  --SEGYLLFYHKQ 618
           ..********985 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

PAPPSANPES EARAACGGRS PGAVPASPPP PLRAAPSLSS RSALFPSPVL WPSRPRSSPG 60
GELASSSPPS PPPPVRGRAL PPMVSRPEPE GEAMDAELAV APPGCSHLSS FKVDNWKQNL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCGCGCCGC CCTCAGCGAA CCCGGAGAGC GAAGCGCGGG CGGCCTGTGG CGGCCGCAGC 60
CCGGGGGCGG TGCCTGCCTC GCCGCCGCCT CCTCTCCGCG CAGCTCCATC TTTGTCCAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0000124--C:SAGA complex
GO:0010485--F:H4 histone acetyltransferase activity
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:0016574--P:histone ubiquitination
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000393	Aegilops tauschii	38.12	2.00e-65	243.00
IUUC-Aml-001343	Ailuropoda melanoleuca	93.26	0.00e+00	1071.00
IUUC-Atr-002653	Amborella trichopoda	37.02	2.00e-99	356.00
IUUC-Apl-003433	Anas platyrhynchos	92.99	0.00e+00	957.00
IUUC-Aca-005347	Anolis carolinensis	88.72	0.00e+00	1011.00
IUUC-Ago-007811	Ashbya gossypii	29.43	3.00e-52	199.00
IUUC-Acl-008124	Aspergillus clavatus	30.29	2.00e-57	216.00
IUUC-Afl-008464	Aspergillus flavus	33.18	1.00e-53	203.00
IUUC-Afu-008912	Aspergillus fumigatus	30.04	7.00e-55	207.00
IUUC-Ani-009168	Aspergillus nidulans	32.44	2.00e-57	216.00
IUUC-Ang-009694	Aspergillus niger	32.52	7.00e-56	211.00
IUUC-Aor-010035	Aspergillus oryzae	35.36	2.00e-38	152.00
IUUC-Ate-010382	Aspergillus terreus	31.55	1.00e-51	197.00
IUUC-Ame-011253	Astyanax mexicanus	83.16	0.00e+00	830.00
IUUC-Bgr-012150	Blumeria graminis	31.13	2.00e-49	189.00
IUUC-Bta-013303	Bos taurus	93.77	0.00e+00	1045.00
IUUC-Bci-013604	Botrytis cinerea	31.26	1.00e-57	217.00
IUUC-Bdi-014171	Brachypodium distachyon	35.48	1.00e-77	283.00
IUUC-Cja-019283	Callithrix jacchus	94.09	0.00e+00	868.00
IUUC-Cfa-021239	Canis familiaris	94.25	0.00e+00	962.00
IUUC-Cpo-022354	Cavia porcellus	94.09	0.00e+00	1067.00
IUUC-Csa-023145	Chlorocebus sabaeus	95.19	0.00e+00	1081.00
IUUC-Cho-024938	Choloepus hoffmanni	84.85	2.00e-63	236.00
IUUC-Cin-025109	Ciona intestinalis	55.98	3.00e-120	424.00
IUUC-Csv-026214	Ciona savignyi	55.05	2.00e-173	602.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	31.36	6.00e-55	208.00
IUUC-Cne-027085	Cryptococcus neoformans	32.70	7.00e-65	241.00
IUUC-Dre-027433	Danio rerio	90.70	0.00e+00	921.00
IUUC-Dno-030095	Dasypus novemcinctus	93.81	0.00e+00	959.00
IUUC-Dor-030481	Dipodomys ordii	88.36	8.00e-98	350.00
IUUC-Dse-031415	Dothistroma septosporum	30.36	2.00e-59	223.00
IUUC-Dme-032074	Drosophila melanogaster	50.64	1.00e-139	489.00
IUUC-Ete-033175	Echinops telfairi	76.26	0.00e+00	728.00
IUUC-Eca-033736	Equus caballus	94.23	0.00e+00	957.00
IUUC-Eeu-034814	Erinaceus europaeus	88.21	2.00e-130	459.00
IUUC-Fca-035861	Felis catus	94.64	0.00e+00	962.00
IUUC-Fal-037645	Ficedula albicollis	93.29	0.00e+00	942.00
IUUC-Fox-038046	Fusarium oxysporum	31.17	2.00e-55	209.00
IUUC-Fso-038321	Fusarium solani	32.24	6.00e-55	207.00
IUUC-Gmo-038474	Gadus morhua	94.26	1.00e-171	596.00
IUUC-Ggr-040044	Gaeumannomyces graminis	32.08	2.00e-56	213.00
IUUC-Gga-040624	Gallus gallus	91.63	0.00e+00	1024.00
IUUC-Gac-042197	Gasterosteus aculeatus	84.38	0.00e+00	927.00
IUUC-Gma-042897	Glycine max	32.94	4.00e-86	311.00
IUUC-Ggo-044409	Gorilla gorilla	95.38	0.00e+00	1083.00
IUUC-Hsa-046521	Homo sapiens	95.19	0.00e+00	1081.00
IUUC-Hvu-047739	Hordeum vulgare	39.23	4.00e-70	258.00
IUUC-Itr-048375	Ictidomys tridecemlineatus	94.72	0.00e+00	1053.00
IUUC-Kpa-049135	Komagataella pastoris	34.65	3.00e-67	249.00
IUUC-Lch-050537	Latimeria chalumnae	90.65	0.00e+00	1013.00
IUUC-Lpe-050969	Leersia perrieri	38.13	6.00e-73	268.00
IUUC-Loc-052765	Lepisosteus oculatus	83.65	0.00e+00	917.00
IUUC-Lma-053105	Leptosphaeria maculans	33.01	7.00e-67	248.00
IUUC-Laf-053571	Loxodonta africana	94.23	0.00e+00	959.00
IUUC-Mcc-055166	Macaca mulatta	95.19	0.00e+00	1081.00
IUUC-Mor-057103	Magnaporthe oryzae	31.00	9.00e-58	217.00
IUUC-Mpo-057621	Magnaporthe poae	32.08	1.00e-55	210.00
IUUC-Mtr-057894	Medicago truncatula	36.97	3.00e-85	309.00
IUUC-Mla-059185	Melampsora laricipopulina	29.63	3.00e-42	166.00
IUUC-Mga-059709	Meleagris gallopavo	92.99	0.00e+00	957.00
IUUC-Mvi-060530	Microbotryum violaceum	32.82	3.00e-57	215.00
IUUC-Mmr-060988	Microcebus murinus	95.74	0.00e+00	1080.00
IUUC-Mdo-063065	Monodelphis domestica	91.41	0.00e+00	1019.00
IUUC-Mmu-063829	Mus musculus	94.45	0.00e+00	1073.00
IUUC-Mac-065419	Musa acuminata	35.47	5.00e-75	275.00
IUUC-Mpu-066687	Mustela putorius furo	92.78	0.00e+00	1038.00
IUUC-Nfi-068423	Neosartorya fischeri	30.49	9.00e-55	207.00
IUUC-Ncr-068809	Neurospora crassa	29.32	7.00e-57	214.00
IUUC-Nle-069261	Nomascus leucogenys	91.31	0.00e+00	1025.00
IUUC-Opr-070469	Ochotona princeps	76.77	0.00e+00	681.00
IUUC-Ont-071961	Oreochromis niloticus	86.20	0.00e+00	963.00
IUUC-Oan-073565	Ornithorhynchus anatinus	86.38	0.00e+00	925.00
IUUC-Ocu-074435	Oryctolagus cuniculus	95.27	0.00e+00	1048.00
IUUC-Oba-075688	Oryza barthii	36.62	9.00e-77	281.00
IUUC-Obr-076652	Oryza brachyantha	41.69	7.00e-75	274.00
IUUC-Ogl-077910	Oryza glaberrima	36.82	6.00e-80	291.00
IUUC-Ogu-078479	Oryza glumaepatula	36.82	6.00e-80	291.00
IUUC-Oin-079697	Oryza indica	39.71	5.00e-77	281.00
IUUC-Olo-080811	Oryza longistaminata	41.38	2.00e-53	202.00
IUUC-Ome-081706	Oryza meridionalis	36.82	9.00e-79	288.00
IUUC-Oni-083070	Oryza nivara	36.42	8.00e-80	291.00
IUUC-Opu-083605	Oryza punctata	40.16	6.00e-68	251.00
IUUC-Oru-084522	Oryza rufipogon	36.82	6.00e-80	291.00
IUUC-Osa-085351	Oryza sativa	39.61	3.00e-77	282.00
IUUC-Ola-086743	Oryzias latipes	85.17	0.00e+00	745.00
IUUC-Oar-089319	Ovis aries	94.21	0.00e+00	956.00
IUUC-Ptr-090783	Pan troglodytes	91.85	0.00e+00	964.00
IUUC-Pan-092927	Papio anubis	95.01	0.00e+00	1080.00
IUUC-Psi-093670	Pelodiscus sinensis	92.07	0.00e+00	958.00
IUUC-Pma-094323	Petromyzon marinus	67.67	0.00e+00	705.00
IUUC-Pno-095141	Phaeosphaeria nodorum	31.76	5.00e-57	215.00
IUUC-Ppa-095413	Physcomitrella patens	35.28	6.00e-87	315.00
IUUC-Pfo-096462	Poecilia formosa	87.01	0.00e+00	984.00
IUUC-Pab-097612	Pongo abelii	95.38	0.00e+00	1082.00
IUUC-Pop-099558	Populus trichocarpa	35.03	6.00e-90	324.00
IUUC-Ppe-102020	Prunus persica	36.87	2.00e-93	336.00
IUUC-Pva-102409	Pteropus vampyrus	77.45	0.00e+00	840.00
IUUC-Pgr-103657	Puccinia graminis	30.81	2.00e-38	153.00
IUUC-Pte-104340	Pyrenophora teres	31.67	1.00e-59	224.00
IUUC-Pyt-104782	Pyrenophora triticirepentis	32.43	3.00e-65	242.00
IUUC-Rno-105247	Rattus norvegicus	94.64	0.00e+00	1075.00
IUUC-Sce-106247	Saccharomyces cerevisiae	30.75	5.00e-51	195.00
IUUC-Sha-107538	Sarcophilus harrisii	95.39	2.00e-123	434.00
IUUC-Sja-107656	Schizosaccharomyces japonicus	34.99	9.00e-68	250.00
IUUC-Spo-108226	Schizosaccharomyces pombe	31.43	2.00e-60	226.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	31.34	5.00e-54	205.00
IUUC-Sit-109716	Setaria italica	36.35	4.00e-80	292.00
IUUC-Sly-111077	Solanum lycopersicum	37.50	6.00e-82	298.00
IUUC-Sbi-114205	Sorghum bicolor	36.00	6.00e-82	298.00
IUUC-Tgu-116938	Taeniopygia guttata	92.58	0.00e+00	951.00
IUUC-Tru-117622	Takifugu rubripes	88.95	0.00e+00	998.00
IUUC-Tsy-119431	Tarsius syrichta	83.47	0.00e+00	813.00
IUUC-Tni-120119	Tetraodon nigroviridis	88.76	0.00e+00	994.00
IUUC-Tca-121716	Theobroma cacao	34.46	2.00e-86	313.00
IUUC-Tre-122139	Trichoderma reesei	32.01	5.00e-55	208.00
IUUC-Tvi-122599	Trichoderma virens	31.25	7.00e-56	211.00
IUUC-Tae-125608	Triticum aestivum	36.09	8.00e-87	314.00
IUUC-Tme-127115	Tuber melanosporum	35.33	1.00e-79	290.00
IUUC-Uma-129455	Ustilago maydis	35.47	4.00e-33	136.00
IUUC-Vda-129829	Verticillium dahliae	32.89	5.00e-36	144.00
IUUC-Vvi-131477	Vitis vinifera	35.65	1.00e-78	286.00
IUUC-Xtr-132444	Xenopus tropicalis	91.03	0.00e+00	1016.00
IUUC-Xma-133514	Xiphophorus maculatus	89.33	0.00e+00	999.00
IUUC-Yli-134357	Yarrowia lipolytica	30.81	3.00e-48	186.00
IUUC-Zma-134945	Zea mays	36.16	1.00e-79	290.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence