iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	miRecords
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	2.80e-13	50.6	164	211

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            ++l+++++r+Lq+LCR +I+ ++g+++l    ++PL+++L+dYL+++++q
   Q: 164  GAPLRQRRVRPLQELCRQRIVAAVGRENL---ARIPLNPVLRDYLSSFPFQ 211
           6789*************************...***************9986 PP

Organism

Mus musculus

Functional Description
(View)

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2 (By similarity). SOCS1 appears to be a negative regulator in IGF1R signaling pathway (By similarity).

Protein Sequence
(Fasta)

MVARNQVAAD NAISPAAEPR RRSEPSSSSS SSSPAAPVRP RPCPAVPAPA PGDTHFRTFR 60
SHSDYRRITR TSALLDACGF YWGPLSVHGA HERLRAEPVG TFLVRDSRQR NCFFALSVKM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCAGAGAGA ACTGCGGCCG TGGCAGCGGC ACGGCTCCCA GCCCCGGAGC ATGCGCGACA 60
GCCGCCCCGG AGCCCCCAGC CGCGGCTCCC CGCGTCCTGC CGCCAGGTGA GCCAAGGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0341--Growth regulation
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0005159--F:insulin-like growth factor receptor binding
GO:0019210--F:kinase inhibitor activity
GO:0019901--F:protein kinase binding
GO:0004860--F:protein kinase inhibitor activity
GO:0071230--P:cellular response to amino acid stimulus
GO:0071345--P:cellular response to cytokine stimulus
GO:0071407--P:cellular response to organic cyclic compound
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0007259--P:JAK-STAT cascade
GO:0060397--P:JAK-STAT cascade involved in growth hormone signaling pathway
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0016567--P:protein ubiquitination
GO:0010534--P:regulation of activation of JAK2 kinase activity
GO:0050707--P:regulation of cytokine secretion
GO:0040008--P:regulation of growth
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway
GO:0046425--P:regulation of JAK-STAT cascade
GO:0001932--P:regulation of protein phosphorylation
GO:0060338--P:regulation of type I interferon-mediated signaling pathway
GO:0042510--P:regulation of tyrosine phosphorylation of Stat1 protein

KEGG

mmu:12703

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001204	Ailuropoda melanoleuca	89.38	3.00e-78	283.00
IUUC-Apl-003313	Anas platyrhynchos	59.43	3.00e-71	260.00
IUUC-Aca-005109	Anolis carolinensis	69.62	4.00e-64	236.00
IUUC-Ame-011550	Astyanax mexicanus	48.75	4.00e-48	183.00
IUUC-Bta-013411	Bos taurus	84.75	5.00e-91	327.00
IUUC-Cja-019595	Callithrix jacchus	92.92	2.00e-92	331.00
IUUC-Cfa-020563	Canis familiaris	95.03	1.00e-88	318.00
IUUC-Cpo-021374	Cavia porcellus	86.18	3.00e-93	334.00
IUUC-Csa-023333	Chlorocebus sabaeus	86.85	5.00e-92	330.00
IUUC-Dre-028507	Danio rerio	46.79	9.00e-45	172.00
IUUC-Dno-029406	Dasypus novemcinctus	90.09	4.00e-91	327.00
IUUC-Ete-032399	Echinops telfairi	90.09	1.00e-90	325.00
IUUC-Eca-033519	Equus caballus	85.85	1.00e-88	318.00
IUUC-Fal-036726	Ficedula albicollis	60.38	1.00e-73	268.00
IUUC-Gmo-039667	Gadus morhua	49.56	1.00e-26	112.00
IUUC-Gga-040970	Gallus gallus	71.70	5.00e-71	260.00
IUUC-Gac-041838	Gasterosteus aculeatus	45.62	3.00e-36	144.00
IUUC-Ggo-045569	Gorilla gorilla	86.32	5.00e-93	333.00
IUUC-Hsa-046010	Homo sapiens	93.87	7.00e-92	329.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	97.52	8.00e-91	326.00
IUUC-Lch-050219	Latimeria chalumnae	62.66	2.00e-62	231.00
IUUC-Loc-052494	Lepisosteus oculatus	57.23	2.00e-54	205.00
IUUC-Laf-054219	Loxodonta africana	94.85	3.00e-71	260.00
IUUC-Mcc-054830	Macaca mulatta	86.05	9.00e-92	329.00
IUUC-Meu-056565	Macropus eugenii	71.36	1.00e-78	285.00
IUUC-Mga-060153	Meleagris gallopavo	70.19	2.00e-70	258.00
IUUC-Mmr-061365	Microcebus murinus	97.52	5.00e-91	326.00
IUUC-Mdo-062824	Monodelphis domestica	66.82	2.00e-77	281.00
IUUC-Mpu-066839	Mustela putorius furo	87.50	3.00e-92	330.00
IUUC-Mlu-067829	Myotis lucifugus	96.27	4.00e-90	323.00
IUUC-Nle-069592	Nomascus leucogenys	88.21	4.00e-88	317.00
IUUC-Ont-072173	Oreochromis niloticus	45.00	4.00e-38	150.00
IUUC-Oan-073586	Ornithorhynchus anatinus	53.27	6.00e-26	109.00
IUUC-Ocu-073996	Oryctolagus cuniculus	98.76	4.00e-92	330.00
IUUC-Oba-075150	Oryza barthii	29.41	6.60e-02	30.40
IUUC-Ola-087158	Oryzias latipes	46.88	8.00e-40	156.00
IUUC-Oga-088076	Otolemur garnettii	93.40	3.00e-92	330.00
IUUC-Ptr-091241	Pan troglodytes	94.34	1.00e-92	332.00
IUUC-Pan-091836	Papio anubis	86.32	1.00e-92	331.00
IUUC-Psi-093628	Pelodiscus sinensis	61.79	4.00e-73	267.00
IUUC-Pfo-097501	Poecilia formosa	45.28	5.00e-37	147.00
IUUC-Pab-098170	Pongo abelii	87.32	1.00e-91	328.00
IUUC-Pop-100072	Populus trichocarpa	30.77	2.30e-02	32.70
IUUC-Pva-102796	Pteropus vampyrus	87.32	2.00e-91	328.00
IUUC-Rno-105319	Rattus norvegicus	98.11	9.00e-96	342.00
IUUC-Sha-107201	Sarcophilus harrisii	79.87	3.00e-73	266.00
IUUC-Ssc-116004	Sus scrofa	89.09	2.00e-92	332.00
IUUC-Tgu-116836	Taeniopygia guttata	60.38	4.00e-72	263.00
IUUC-Tru-118090	Takifugu rubripes	42.50	5.00e-36	144.00
IUUC-Tni-120719	Tetraodon nigroviridis	44.38	5.00e-33	134.00
IUUC-Vpa-130235	Vicugna pacos	86.98	1.00e-91	328.00
IUUC-Xtr-132610	Xenopus tropicalis	65.22	2.00e-66	244.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence