iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132610

UUCD1 version

UUC-XeT-00928

Ensembl Protein ID

ENSXETP00000008137.3

UniProt Accession

Q5M8D9; Q5M8D9_XENTR

Genbank Protein ID

AAH88083.1; CAJ81426.1

Protein Name

Novel protein similar to suppressor of cytokine signaling 1; Suppressor of cytokine signaling 1; Suppressor of cytokine-signaling 1

Genbank Nucleotide ID

AAMC01110298; CR761191

Gene Name

socs1; TEgg054n06.1-001

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000024895.2	ENSXETT00000008137.3	ENSXETP00000008137.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	58.29	9.00e-66	247.00	IUUC-Hsa-046010

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MVANSKVEAD NAVADRRSQH LEASVSDRSQ IQPARALHPS PGRATPALLL SDTHFRTFRS 60
HSDFTIITKT SSMLDTCGFY WGPMDVNVAH DKLKSEPVGT FLIRDSRQKN CFFAISVKTA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCATACGCG GAGCTGGCGA GTCAATGCTC TGCTCAGCAG CAGCCCGCAG TACCCCCAGG 60
TAGCACAGAC AGCGGGGAGC TGGAGTACGC AGGAGATTAT GGTTCTTATT ACTGGCGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0016567--P:protein ubiquitination
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway

KEGG

xtr:496789

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001204	Ailuropoda melanoleuca	58.43	2.00e-56	211.00
IUUC-Apl-003313	Anas platyrhynchos	67.30	6.00e-79	286.00
IUUC-Aca-005109	Anolis carolinensis	58.86	1.00e-57	215.00
IUUC-Ame-011550	Astyanax mexicanus	48.11	1.00e-51	195.00
IUUC-Bta-013411	Bos taurus	64.60	8.00e-66	243.00
IUUC-Cja-019595	Callithrix jacchus	57.35	3.00e-67	247.00
IUUC-Cfa-020563	Canis familiaris	63.35	1.00e-64	238.00
IUUC-Cpo-021374	Cavia porcellus	65.84	7.00e-67	246.00
IUUC-Csa-023333	Chlorocebus sabaeus	65.22	3.00e-66	244.00
IUUC-Dre-028507	Danio rerio	50.48	1.00e-49	189.00
IUUC-Dno-029406	Dasypus novemcinctus	65.22	2.00e-65	241.00
IUUC-Ete-032399	Echinops telfairi	63.98	9.00e-65	239.00
IUUC-Eca-033519	Equus caballus	53.55	2.00e-62	231.00
IUUC-Fal-036726	Ficedula albicollis	65.40	3.00e-76	277.00
IUUC-Gmo-039667	Gadus morhua	42.48	2.00e-22	98.20
IUUC-Gga-040970	Gallus gallus	66.82	2.00e-78	284.00
IUUC-Gac-041838	Gasterosteus aculeatus	43.46	1.00e-38	152.00
IUUC-Ggo-045569	Gorilla gorilla	55.45	2.00e-66	244.00
IUUC-Hsa-046010	Homo sapiens	58.29	6.00e-67	246.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	65.22	4.00e-66	243.00
IUUC-Lch-050219	Latimeria chalumnae	67.30	1.00e-62	232.00
IUUC-Loc-052494	Lepisosteus oculatus	56.87	2.00e-61	228.00
IUUC-Laf-054219	Loxodonta africana	61.97	6.00e-51	192.00
IUUC-Mcc-054830	Macaca mulatta	65.22	3.00e-66	244.00
IUUC-Meu-056565	Macropus eugenii	63.30	4.00e-76	276.00
IUUC-Mga-060153	Meleagris gallopavo	66.35	4.00e-74	270.00
IUUC-Mmr-061365	Microcebus murinus	65.22	3.00e-66	244.00
IUUC-Mdo-062824	Monodelphis domestica	61.99	1.00e-75	275.00
IUUC-Mmu-064120	Mus musculus	65.22	3.00e-66	243.00
IUUC-Mpu-066839	Mustela putorius furo	65.22	3.00e-66	244.00
IUUC-Mlu-067829	Myotis lucifugus	65.22	5.00e-66	243.00
IUUC-Nle-069592	Nomascus leucogenys	63.35	2.00e-63	234.00
IUUC-Ont-072173	Oreochromis niloticus	48.82	4.00e-39	154.00
IUUC-Oan-073586	Ornithorhynchus anatinus	45.79	4.00e-23	100.00
IUUC-Ocu-073996	Oryctolagus cuniculus	65.22	3.00e-66	243.00
IUUC-Ola-087158	Oryzias latipes	48.75	7.00e-39	153.00
IUUC-Oga-088076	Otolemur garnettii	55.19	1.00e-65	241.00
IUUC-Ptr-091241	Pan troglodytes	57.82	3.00e-67	247.00
IUUC-Pan-091836	Papio anubis	54.98	2.00e-66	244.00
IUUC-Psi-093628	Pelodiscus sinensis	68.25	1.00e-79	288.00
IUUC-Pfo-097501	Poecilia formosa	45.28	2.00e-36	145.00
IUUC-Pab-098170	Pongo abelii	65.22	3.00e-66	244.00
IUUC-Pop-100072	Populus trichocarpa	29.09	1.50e-01	30.00
IUUC-Pva-102796	Pteropus vampyrus	64.60	9.00e-66	242.00
IUUC-Rno-105319	Rattus norvegicus	65.22	3.00e-66	243.00
IUUC-Sha-107201	Sarcophilus harrisii	72.08	3.00e-67	246.00
IUUC-Ssc-116004	Sus scrofa	56.82	3.00e-67	247.00
IUUC-Tgu-116836	Taeniopygia guttata	65.40	4.00e-77	280.00
IUUC-Tru-118090	Takifugu rubripes	46.39	3.00e-38	150.00
IUUC-Tni-120719	Tetraodon nigroviridis	46.88	4.00e-33	134.00
IUUC-Vpa-130235	Vicugna pacos	65.22	3.00e-66	244.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence