iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-005375

UUCD1 version

UUC-AnC-00401

Ensembl Protein ID

ENSACAP00000003961.3

UniProt Accession

H9G8G5; H9G8G5_ANOCA

Protein Name

Uncharacterized protein

Gene Name

HACE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000003993.3	ENSACAT00000004053.3	ENSACAP00000003961.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-117	393.1	576	906

Active Site

Position(s)	Description	Evidence
877	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           +++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s + np+hl++F+f+G++lg+al +++l+++
   Q: 576  YAKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIVNPDYALFTQSA-DGTTFQPNSNSSV-NPDHLNYFRFAGQILGLALNHRQLVNI 661
           678999**************.**********************6666.67788*******9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +++sfyk++lg +++++d++ +dpe+ k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG++i Vt+eNk eYv+lv+e
   Q: 662  YFTRSFYKHILGIPVNYQDVAYIDPEYGKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGASILVTQENKAEYVQLVTE 747
           ***********************************99...************************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++ i+ q++af +Gf+  ip+ l++lF+e elell++G++eidv+d+ k+t+y++gy++d+p+iqwFwev+ee+s+eer  +LqFv
   Q: 748  LRMTRAIQPQINAFLQGFHMFIPPPLIQLFDEYELELLLSGMPEIDVNDWIKNTEYTSGYEKDDPVIQWFWEVVEELSQEERVLLLQFV 836
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           Tgssr+P+gGfa ++     + f+i      ++ lPss+TC+n+LkLPeY++keilk++Ll+A + +  g
   Q: 837  TGSSRVPHGGFAHIMggsgLQNFTIAAvPYIPNLLPSSSTCINMLKLPEYPNKEILKNRLLVALHCGsYG 906
           *******************8889999856677********************************986555 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MERAMEQLNR LTRSLRRART VELPEDNETA LYTLMPMVMA DQHRSVSELL SNSKFDVNYA 60
FGCEKRSLLH IAANCGSVEC LVLLLKKGAN PNYQDISGCT PLHLAARNGQ KKCMGKLLEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAGCAAGGG CGGAAGTGTC TCTGAAGCAG CAGCAGAAGC GGCGTTGTCT ACCCACGCGC 60
GCTATGGCGC TTCCGGGGCG CATGCGCAGT AGAAGGCGAG CGTGCCTCGG CGAGGCGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF12796--Ank_2
PF00632--HECT

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0000139--C:Golgi membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030334--P:regulation of cell migration

KEGG

acs:100562508

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001490	Ailuropoda melanoleuca	90.80	0.00e+00	1725.00
IUUC-Apl-003400	Anas platyrhynchos	86.77	0.00e+00	1155.00
IUUC-Ame-011847	Astyanax mexicanus	83.70	0.00e+00	1627.00
IUUC-Bta-012831	Bos taurus	90.56	0.00e+00	1687.00
IUUC-Cja-019160	Callithrix jacchus	91.33	0.00e+00	1733.00
IUUC-Cfa-020346	Canis familiaris	90.99	0.00e+00	1730.00
IUUC-Cpo-021766	Cavia porcellus	90.23	0.00e+00	1722.00
IUUC-Csa-023768	Chlorocebus sabaeus	91.21	0.00e+00	1734.00
IUUC-Cho-024688	Choloepus hoffmanni	85.55	0.00e+00	1073.00
IUUC-Cin-025417	Ciona intestinalis	50.00	5.00e-139	488.00
IUUC-Csv-025993	Ciona savignyi	43.88	0.00e+00	753.00
IUUC-Dre-027819	Danio rerio	84.71	0.00e+00	1623.00
IUUC-Dno-029027	Dasypus novemcinctus	90.82	0.00e+00	1731.00
IUUC-Dor-030327	Dipodomys ordii	84.65	0.00e+00	1521.00
IUUC-Ete-032966	Echinops telfairi	84.84	0.00e+00	1603.00
IUUC-Eca-034339	Equus caballus	91.21	0.00e+00	1734.00
IUUC-Eeu-034544	Erinaceus europaeus	62.14	2.00e-172	599.00
IUUC-Fca-035617	Felis catus	89.21	0.00e+00	1209.00
IUUC-Fal-036687	Ficedula albicollis	89.49	0.00e+00	1749.00
IUUC-Gmo-039508	Gadus morhua	86.56	0.00e+00	821.00
IUUC-Gga-040845	Gallus gallus	89.60	0.00e+00	1769.00
IUUC-Gac-041894	Gasterosteus aculeatus	84.27	0.00e+00	1579.00
IUUC-Ggo-044465	Gorilla gorilla	87.95	0.00e+00	1657.00
IUUC-Hsa-045731	Homo sapiens	91.32	0.00e+00	1736.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	91.23	0.00e+00	1738.00
IUUC-Lch-050436	Latimeria chalumnae	88.96	0.00e+00	1692.00
IUUC-Loc-052287	Lepisosteus oculatus	84.01	0.00e+00	1652.00
IUUC-Laf-053846	Loxodonta africana	91.21	0.00e+00	1736.00
IUUC-Mcc-055845	Macaca mulatta	91.32	0.00e+00	1736.00
IUUC-Meu-056060	Macropus eugenii	93.95	0.00e+00	682.00
IUUC-Mga-059935	Meleagris gallopavo	91.89	0.00e+00	1743.00
IUUC-Mmr-060960	Microcebus murinus	91.43	0.00e+00	1739.00
IUUC-Mdo-061851	Monodelphis domestica	88.85	0.00e+00	1743.00
IUUC-Mmu-063657	Mus musculus	90.88	0.00e+00	1730.00
IUUC-Mpu-066161	Mustela putorius furo	94.97	0.00e+00	798.00
IUUC-Mlu-067354	Myotis lucifugus	88.88	0.00e+00	1648.00
IUUC-Nle-069112	Nomascus leucogenys	91.32	0.00e+00	1736.00
IUUC-Opr-070686	Ochotona princeps	85.42	0.00e+00	780.00
IUUC-Ont-072398	Oreochromis niloticus	84.00	0.00e+00	1578.00
IUUC-Oan-073194	Ornithorhynchus anatinus	90.88	0.00e+00	1665.00
IUUC-Ocu-074397	Oryctolagus cuniculus	81.99	0.00e+00	1504.00
IUUC-Ola-086777	Oryzias latipes	79.58	0.00e+00	1551.00
IUUC-Oga-088684	Otolemur garnettii	91.44	0.00e+00	1735.00
IUUC-Oar-089428	Ovis aries	90.75	0.00e+00	1702.00
IUUC-Ptr-090529	Pan troglodytes	91.43	0.00e+00	1738.00
IUUC-Pan-091702	Papio anubis	91.43	0.00e+00	1738.00
IUUC-Psi-093969	Pelodiscus sinensis	89.43	0.00e+00	1701.00
IUUC-Pfo-097364	Poecilia formosa	85.43	0.00e+00	1603.00
IUUC-Pab-098574	Pongo abelii	91.32	0.00e+00	1736.00
IUUC-Pca-100525	Procavia capensis	82.96	2.00e-171	596.00
IUUC-Pva-102365	Pteropus vampyrus	79.78	0.00e+00	1464.00
IUUC-Rno-105153	Rattus norvegicus	91.10	0.00e+00	1736.00
IUUC-Sha-107319	Sarcophilus harrisii	88.75	0.00e+00	1736.00
IUUC-Sar-113449	Sorex araneus	72.25	2.00e-154	539.00
IUUC-Ssc-115865	Sus scrofa	91.10	0.00e+00	1733.00
IUUC-Tgu-117225	Taeniopygia guttata	89.07	0.00e+00	1755.00
IUUC-Tru-118026	Takifugu rubripes	81.76	0.00e+00	1559.00
IUUC-Tsy-119407	Tarsius syrichta	78.24	0.00e+00	1436.00
IUUC-Tni-120234	Tetraodon nigroviridis	83.07	0.00e+00	1252.00
IUUC-Tur-126774	Triticum urartu	29.17	8.00e-45	175.00
IUUC-Tbe-127708	Tupaia belangeri	79.71	0.00e+00	786.00
IUUC-Ttr-128667	Tursiops truncatus	90.88	0.00e+00	1731.00
IUUC-Vpa-130200	Vicugna pacos	90.50	0.00e+00	1668.00
IUUC-Xtr-132176	Xenopus tropicalis	86.35	0.00e+00	1683.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence