iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012322

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

DAAA02012048

Gene Name

KMT2C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000024199.4	ENSBTAT00000028347.5	ENSBTAP00000028347.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	3.40e-29	100.9	866	916

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedek.slveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           ++C vCg+ g++ +  l+ C++C +++Hp C+++++ + + ++  w C +C+
   Q: 866  DMCVVCGSFGQGAEgRLLACSQCGQCYHPYCVSIKITKVVLSK-GWRCLECT 916
           79*********9999********************66666555.5******6 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

EIKEQSAEED AEAEVDSSKQ PVPALQRSVS EESASSLVSV GVEAKISEQL CAFCYCGEKS 60
SLGQGDLKQF RVTPGFILPW KNQPSNKKDV DDNSSGTCEK TQNSAPRKQR GQRKERPQQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAATCAAAG AACAATCAGC AGAAGAGGAT GCTGAAGCAG AAGTGGACAG CAGCAAGCAG 60
CCGGTCCCAG CCCTTCAGCG TTCTGTGTCT GAGGAATCCG CAAGCTCCCT GGTCTCTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0044666--C:MLL3/4 complex
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0003723--F:RNA binding
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002314	Ailuropoda melanoleuca	85.14	0.00e+00	7060.00
IUUC-Apl-003311	Anas platyrhynchos	70.68	0.00e+00	5568.00
IUUC-Aca-004705	Anolis carolinensis	65.39	0.00e+00	5115.00
IUUC-Cel-018354	Caenorhabditis elegans	29.38	1.00e-64	243.00
IUUC-Cja-019983	Callithrix jacchus	83.62	0.00e+00	7061.00
IUUC-Cfa-020903	Canis familiaris	83.97	0.00e+00	7079.00
IUUC-Cpo-021732	Cavia porcellus	78.87	0.00e+00	6554.00
IUUC-Csa-023083	Chlorocebus sabaeus	81.60	0.00e+00	5230.00
IUUC-Cho-024469	Choloepus hoffmanni	78.03	0.00e+00	2157.00
IUUC-Dre-028110	Danio rerio	64.42	0.00e+00	1243.00
IUUC-Dor-030569	Dipodomys ordii	75.68	0.00e+00	4244.00
IUUC-Dme-031590	Drosophila melanogaster	33.60	3.00e-68	254.00
IUUC-Eca-033945	Equus caballus	84.52	0.00e+00	5022.00
IUUC-Fca-035922	Felis catus	84.32	0.00e+00	6886.00
IUUC-Gac-041896	Gasterosteus aculeatus	49.44	0.00e+00	1342.00
IUUC-Ggo-044812	Gorilla gorilla	81.76	0.00e+00	6905.00
IUUC-Hsa-046595	Homo sapiens	84.00	0.00e+00	7074.00
IUUC-Itr-048303	Ictidomys tridecemlineatus	81.74	0.00e+00	6689.00
IUUC-Lch-050086	Latimeria chalumnae	56.60	0.00e+00	2571.00
IUUC-Loc-052891	Lepisosteus oculatus	54.03	0.00e+00	1719.00
IUUC-Laf-054348	Loxodonta africana	79.75	0.00e+00	2922.00
IUUC-Mcc-054868	Macaca mulatta	83.95	0.00e+00	7033.00
IUUC-Meu-056322	Macropus eugenii	62.54	0.00e+00	1082.00
IUUC-Mga-059541	Meleagris gallopavo	70.26	0.00e+00	5439.00
IUUC-Mmr-061092	Microcebus murinus	81.56	0.00e+00	5224.00
IUUC-Mdo-062610	Monodelphis domestica	74.45	0.00e+00	2014.00
IUUC-Mmu-063666	Mus musculus	80.17	0.00e+00	6580.00
IUUC-Mpu-066366	Mustela putorius furo	84.01	0.00e+00	6628.00
IUUC-Mlu-068201	Myotis lucifugus	82.72	0.00e+00	6670.00
IUUC-Nle-069232	Nomascus leucogenys	80.91	0.00e+00	5200.00
IUUC-Opr-070625	Ochotona princeps	73.12	0.00e+00	1228.00
IUUC-Ont-072401	Oreochromis niloticus	58.05	0.00e+00	1056.00
IUUC-Oan-072945	Ornithorhynchus anatinus	72.28	0.00e+00	3252.00
IUUC-Ocu-074920	Oryctolagus cuniculus	79.00	0.00e+00	5039.00
IUUC-Ola-086436	Oryzias latipes	47.01	0.00e+00	1326.00
IUUC-Oga-088637	Otolemur garnettii	78.28	0.00e+00	4053.00
IUUC-Oar-089363	Ovis aries	93.25	0.00e+00	7557.00
IUUC-Ptr-091527	Pan troglodytes	83.94	0.00e+00	7122.00
IUUC-Pan-092102	Papio anubis	81.67	0.00e+00	6778.00
IUUC-Pma-094252	Petromyzon marinus	45.98	3.00e-163	570.00
IUUC-Pfo-096288	Poecilia formosa	48.12	0.00e+00	1484.00
IUUC-Pab-098241	Pongo abelii	82.36	0.00e+00	4507.00
IUUC-Pca-100103	Procavia capensis	77.72	0.00e+00	1520.00
IUUC-Pva-102238	Pteropus vampyrus	78.42	0.00e+00	2579.00
IUUC-Rno-105395	Rattus norvegicus	72.01	0.00e+00	1043.00
IUUC-Sha-106550	Sarcophilus harrisii	70.05	0.00e+00	4254.00
IUUC-Sar-113183	Sorex araneus	90.68	9.00e-157	550.00
IUUC-Tgu-116677	Taeniopygia guttata	69.71	0.00e+00	5266.00
IUUC-Tru-118037	Takifugu rubripes	59.59	0.00e+00	1198.00
IUUC-Tsy-118932	Tarsius syrichta	82.95	0.00e+00	5026.00
IUUC-Tni-119970	Tetraodon nigroviridis	47.61	0.00e+00	1405.00
IUUC-Ttr-129051	Tursiops truncatus	84.35	0.00e+00	6735.00
IUUC-Vpa-130236	Vicugna pacos	80.98	0.00e+00	1955.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence