iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000002310.1	ENSSHAT00000002639.1	ENSSHAP00000002611.1
ENSSHAG00000002310.1	ENSSHAT00000002640.1	ENSSHAP00000002612.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.80e-07	31.7	17	59

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cl  f+  p++  CgH f+++Cl ++   ++ + ++ +CP C+
   Q: 17   CPLCLKLFDA-PITAECGHSFCRNCLLRL--ASDPQAGTVLCPSCQ 59
           ********99.***************999..66679*********7 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MSSAPALMQG MYQDLSCPLC LKLFDAPITA ECGHSFCRNC LLRLASDPQA GTVLCPSCQA 60
PTKPDGLSTN QQLARLVESL AQVPQGHCEE HLDPLSVYCE QDRALICGVC ASLGKHRGHS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGCCCCCAA TCCCCCATCA CAACCCATAT TTAGATCTAG TTGGGCTGAT GGGATGTAAC 60
AGGCTGAGAT ATATAAATAT CACTCTGAGT TCCAGTAAAG TCAGAGAGGA GTTGGGCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0030659--C:cytoplasmic vesicle membrane
GO:0042383--C:sarcolemma
GO:0001786--F:phosphatidylserine binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007517--P:muscle organ development
GO:0003012--P:muscle system process
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0043569--P:negative regulation of insulin-like growth factor receptor signaling pathway
GO:0010832--P:negative regulation of myotube differentiation
GO:0001778--P:plasma membrane repair
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260--P:protein homooligomerization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002377	Ailuropoda melanoleuca	52.67	4.00e-120	424.00
IUUC-Aca-004755	Anolis carolinensis	54.38	9.00e-152	530.00
IUUC-Bta-013476	Bos taurus	59.92	3.00e-153	534.00
IUUC-Cja-018969	Callithrix jacchus	58.73	3.00e-143	501.00
IUUC-Cfa-020155	Canis familiaris	64.45	7.00e-172	596.00
IUUC-Cpo-021646	Cavia porcellus	60.77	4.00e-165	573.00
IUUC-Csa-023855	Chlorocebus sabaeus	65.36	2.00e-111	395.00
IUUC-Dno-029142	Dasypus novemcinctus	66.32	3.00e-165	574.00
IUUC-Dor-030394	Dipodomys ordii	59.57	9.00e-77	280.00
IUUC-Ete-032801	Echinops telfairi	72.09	3.00e-56	211.00
IUUC-Eca-034378	Equus caballus	64.52	8.00e-169	586.00
IUUC-Eeu-034526	Erinaceus europaeus	60.76	4.00e-158	550.00
IUUC-Fca-036440	Felis catus	64.86	3.00e-173	601.00
IUUC-Ggo-045086	Gorilla gorilla	63.87	6.00e-126	443.00
IUUC-Hsa-046533	Homo sapiens	65.83	2.00e-167	581.00
IUUC-Itr-048959	Ictidomys tridecemlineatus	63.83	2.00e-170	592.00
IUUC-Laf-054479	Loxodonta africana	65.21	7.00e-173	599.00
IUUC-Mcc-055814	Macaca mulatta	65.56	5.00e-165	573.00
IUUC-Meu-056767	Macropus eugenii	76.81	3.00e-144	504.00
IUUC-Mmr-061616	Microcebus murinus	65.49	2.00e-174	605.00
IUUC-Mdo-062252	Monodelphis domestica	77.04	0.00e+00	723.00
IUUC-Mmu-063094	Mus musculus	62.58	5.00e-164	570.00
IUUC-Mpu-065885	Mustela putorius furo	52.50	3.00e-124	438.00
IUUC-Nle-069476	Nomascus leucogenys	66.11	2.00e-167	581.00
IUUC-Opr-070871	Ochotona princeps	57.10	3.00e-89	322.00
IUUC-Oan-072738	Ornithorhynchus anatinus	68.90	4.00e-127	447.00
IUUC-Ocu-074132	Oryctolagus cuniculus	54.20	2.00e-127	448.00
IUUC-Oga-088268	Otolemur garnettii	44.58	9.00e-92	330.00
IUUC-Oar-089555	Ovis aries	45.25	7.00e-100	357.00
IUUC-Ptr-090792	Pan troglodytes	65.83	2.00e-167	581.00
IUUC-Pan-092897	Papio anubis	65.83	4.00e-167	580.00
IUUC-Pab-098716	Pongo abelii	66.04	2.00e-167	582.00
IUUC-Pca-100618	Procavia capensis	54.68	6.00e-141	493.00
IUUC-Pva-102430	Pteropus vampyrus	56.34	2.00e-142	498.00
IUUC-Rno-105665	Rattus norvegicus	63.28	3.00e-170	591.00
IUUC-Sar-113028	Sorex araneus	58.25	4.00e-92	331.00
IUUC-Ssc-116124	Sus scrofa	65.14	8.00e-171	593.00
IUUC-Tbe-127273	Tupaia belangeri	79.04	3.00e-107	382.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence