iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pab-098698

Ensembl Protein ID

ENSPPYP00000001273.2

UniProt Accession

H2N6K9; H2N6K9_PONAB

Genbank Protein ID

ENSPPYP00000001273

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01181545

Gene Name

VAV3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000001098.2	ENSPPYT00000001315.2	ENSPPYP00000001273.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.40e-15	55.5	771	822

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+l kGdvv++   +   +gW++g  e +g+ G fP+ +ve+
   Q: 771  IARYDFCARDMRELSLLKGDVVKIY-TKMSANGWWRG--EVNGRVGWFPSTYVEE 822
           688*********************9.999999*****..9*************86 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MEPWKQCAQW LIHCKVLPAN HRVTWDSAQV FDLAQTLRDG VLLCQLLNNL RAHSINLKEI 60
NLRPQMSQFL CLKNIRTFLT ACCETFGMRK SELFEAFDLF DVRDFGKVIE TLSRLSRTPI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGTCGGAA GCCTGTGTGC GGCAGCCGCT GAGCCGGCCG GGGCGCACGG AGAGCGCGCG 60
GGACTCGCTG CAGCGGCGGC CGGGTCGCGG CGCACCCGGG CCGGGACCGG AGCCGAGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain
IPR003096--SM22_calponin

PROSITE

PS50021--CH
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00888--SM22CALPONIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0050853--P:B cell receptor signaling pathway
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007229--P:integrin-mediated signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0030593--P:neutrophil chemotaxis
GO:0030890--P:positive regulation of B cell proliferation
GO:0045785--P:positive regulation of cell adhesion
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0042493--P:response to drug
GO:0007264--P:small GTPase mediated signal transduction
GO:0006906--P:vesicle fusion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001362	Ailuropoda melanoleuca	94.33	0.00e+00	1593.00
IUUC-Apl-003734	Anas platyrhynchos	83.95	0.00e+00	1335.00
IUUC-Aca-004477	Anolis carolinensis	80.34	0.00e+00	1386.00
IUUC-Ame-011279	Astyanax mexicanus	64.19	0.00e+00	1068.00
IUUC-Bta-012722	Bos taurus	93.51	0.00e+00	1579.00
IUUC-Cja-018941	Callithrix jacchus	96.54	0.00e+00	1608.00
IUUC-Cfa-020266	Canis familiaris	94.08	0.00e+00	1415.00
IUUC-Cpo-021966	Cavia porcellus	92.66	0.00e+00	1367.00
IUUC-Csa-023892	Chlorocebus sabaeus	95.91	0.00e+00	1487.00
IUUC-Dre-028199	Danio rerio	64.71	0.00e+00	1075.00
IUUC-Dno-029474	Dasypus novemcinctus	94.21	0.00e+00	1592.00
IUUC-Eca-033961	Equus caballus	93.95	0.00e+00	1442.00
IUUC-Eeu-034719	Erinaceus europaeus	75.56	0.00e+00	781.00
IUUC-Fca-036572	Felis catus	94.01	0.00e+00	1555.00
IUUC-Fal-036802	Ficedula albicollis	82.51	0.00e+00	1464.00
IUUC-Gmo-039409	Gadus morhua	67.92	0.00e+00	1117.00
IUUC-Gga-040884	Gallus gallus	83.47	0.00e+00	1453.00
IUUC-Gac-041395	Gasterosteus aculeatus	69.57	0.00e+00	1201.00
IUUC-Ggo-044460	Gorilla gorilla	94.23	0.00e+00	1410.00
IUUC-Hsa-046099	Homo sapiens	93.60	0.00e+00	1612.00
IUUC-Itr-048144	Ictidomys tridecemlineatus	90.14	0.00e+00	1387.00
IUUC-Lch-049650	Latimeria chalumnae	82.63	1.00e-110	391.00
IUUC-Loc-052487	Lepisosteus oculatus	71.51	0.00e+00	1196.00
IUUC-Laf-054564	Loxodonta africana	93.39	0.00e+00	1583.00
IUUC-Mcc-054622	Macaca mulatta	93.14	0.00e+00	1607.00
IUUC-Meu-056680	Macropus eugenii	83.71	0.00e+00	1382.00
IUUC-Mga-060013	Meleagris gallopavo	80.02	0.00e+00	1369.00
IUUC-Mmr-061251	Microcebus murinus	90.27	0.00e+00	1607.00
IUUC-Mdo-061875	Monodelphis domestica	91.38	0.00e+00	1531.00
IUUC-Mmu-063735	Mus musculus	92.80	0.00e+00	1593.00
IUUC-Mpu-065856	Mustela putorius furo	94.57	0.00e+00	1593.00
IUUC-Mlu-068108	Myotis lucifugus	88.57	0.00e+00	1501.00
IUUC-Nle-069863	Nomascus leucogenys	92.29	0.00e+00	1575.00
IUUC-Opr-070372	Ochotona princeps	82.13	0.00e+00	1011.00
IUUC-Ont-072286	Oreochromis niloticus	69.98	0.00e+00	1186.00
IUUC-Ocu-074194	Oryctolagus cuniculus	95.04	0.00e+00	1601.00
IUUC-Ola-086336	Oryzias latipes	68.82	0.00e+00	1178.00
IUUC-Oar-089272	Ovis aries	93.51	0.00e+00	1618.00
IUUC-Ptr-090652	Pan troglodytes	97.40	0.00e+00	1635.00
IUUC-Pan-092550	Papio anubis	92.26	0.00e+00	1420.00
IUUC-Psi-093784	Pelodiscus sinensis	78.47	0.00e+00	1243.00
IUUC-Pma-094372	Petromyzon marinus	47.35	4.00e-179	621.00
IUUC-Ppa-095161	Physcomitrella patens	43.64	3.00e-09	56.20
IUUC-Pfo-097308	Poecilia formosa	67.50	0.00e+00	1177.00
IUUC-Pva-102262	Pteropus vampyrus	93.88	0.00e+00	1526.00
IUUC-Rno-105421	Rattus norvegicus	92.44	0.00e+00	1597.00
IUUC-Sha-107325	Sarcophilus harrisii	91.26	0.00e+00	1546.00
IUUC-Sar-113456	Sorex araneus	89.02	0.00e+00	1489.00
IUUC-Tgu-116595	Taeniopygia guttata	80.81	0.00e+00	1372.00
IUUC-Tru-117884	Takifugu rubripes	64.76	0.00e+00	1154.00
IUUC-Tsy-119429	Tarsius syrichta	86.14	0.00e+00	1320.00
IUUC-Tni-119951	Tetraodon nigroviridis	67.37	0.00e+00	1105.00
IUUC-Tbe-127995	Tupaia belangeri	80.00	1.00e-162	567.00
IUUC-Ttr-128281	Tursiops truncatus	94.33	0.00e+00	1586.00
IUUC-Xtr-132427	Xenopus tropicalis	70.27	0.00e+00	1235.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence