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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063704
Ensembl Protein ID ENSMUSP00000046774.5
UniProt Accession A2RT67; B2RQ75; Q69ZX2; Q8C6V5; DEND3_MOUSE
Genbank Protein ID BAD32324.1; AAI32390.2; AAI37792.1; BAC35269.1
Protein Name DENN domain-containing protein 3
Genbank Nucleotide ID AK173046; BC132389; BC137791; AK053114
Gene Name Dennd3; Kiaa0870
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000036661.13 ENSMUST00000043414.11 ENSMUSP00000046774.5
ENSMUSG00000036661.13 ENSMUST00000173292.7 ENSMUSP00000134002.1
ENSMUSG00000036661.13 ENSMUST00000162488.7 ENSMUSP00000125657.1
ENSMUSG00000036661.13 ENSMUST00000160267.2 ENSMUSP00000124538.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.60e-07 31.1 1067 1103
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.....sdtllvsGsdDgtikvWDlrtgv 34
           H ++vt+la      +   + s+s Dgt+  W+++t +
   Q: 1067 HRSPVTGLAVhngkkP-SEIYSCSLDGTVIAWNVSTLR 1103
           9********9866543.56**************98876 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Thereby, may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor.
 Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Thereby, may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor.
Protein Sequence
(Fasta)
MAEPAARHLS LPSGLLELCA LLGASQDSLR GLEQIAQKRG VKSASSLVPE VLSVFVPPFT 60
TKEDGQVPGA SCALGKGRRR SFRKKREKPR MEPWKSHPGD SKGPDSEDVT IPGGVDLLAL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063704|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCGTAGGCCC CGCCCATTCC GCGGACGCGG CTGGCTGGCA ACCAGCCCAA GAGAGGCGGG 60
GAGGCTTGGG CAGGGGTGCT CCGCTGGGGT CTGGGTTGTG GGCGCCGGCG CCCTCTGAGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063704|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR005112--dDENN_dom
IPR001194--DENN_dom
IPR005113--uDENN_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50947--DDENN
PS50211--DENN
PS50946--UDENN
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF02141--DENN
SMART

SM00801--dDENN
SM00799--DENN
SM00320--WD40
Gene Ontology

GO:0005622--C:intracellular
GO:0017112--F:Rab guanyl-nucleotide exchange factor activity
GO:0044257--P:cellular protein catabolic process
GO:0008333--P:endosome to lysosome transport
KEGG mmu:105841
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002428 Ailuropoda melanoleuca 77.92 0.00e+00 1931.00
IUUC-Ame-011614 Astyanax mexicanus 53.73 0.00e+00 1355.00
IUUC-Cfa-021105 Canis familiaris 78.19 0.00e+00 1938.00
IUUC-Csv-025827 Ciona savignyi 21.43 3.00e-05 45.10
IUUC-Dor-030471 Dipodomys ordii 83.83 0.00e+00 1127.00
IUUC-Gmo-039067 Gadus morhua 48.54 5.00e-101 362.00
IUUC-Gac-041903 Gasterosteus aculeatus 50.96 0.00e+00 1264.00
IUUC-Hsa-046572 Homo sapiens 78.32 0.00e+00 1897.00
IUUC-Loc-052634 Lepisosteus oculatus 56.48 0.00e+00 1479.00
IUUC-Mcc-055358 Macaca mulatta 79.53 0.00e+00 1972.00
IUUC-Mmr-060775 Microcebus murinus 79.46 0.00e+00 2080.00
IUUC-Ont-072676 Oreochromis niloticus 51.12 0.00e+00 1295.00
IUUC-Oni-082213 Oryza nivara 26.92 2.00e-20 95.10
IUUC-Olu-087744 Ostreococcus lucimarinus 26.87 4.00e-12 67.80
IUUC-Oga-088682 Otolemur garnettii 79.52 0.00e+00 2045.00
IUUC-Ptr-090684 Pan troglodytes 78.52 0.00e+00 1830.00
IUUC-Pan-092645 Papio anubis 79.78 0.00e+00 1990.00
IUUC-Pfo-096475 Poecilia formosa 51.79 0.00e+00 1281.00
IUUC-Ppe-101883 Prunus persica 22.25 1.00e-21 99.00
IUUC-Rno-105167 Rattus norvegicus 92.80 0.00e+00 2334.00
IUUC-Ssc-115459 Sus scrofa 67.89 1.00e-97 348.00
IUUC-Tru-118373 Takifugu rubripes 28.15 2.00e-16 82.00
IUUC-Tni-119750 Tetraodon nigroviridis 28.57 6.00e-16 80.10
Created Date 25-Jun-2017

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